... on these genes. In the present review, we would like to update these informations and focus on the response to insulin and to another actor in Sterol Regulatory Element Binding Protein-1c activation, the endoplasmic reticulum stress. Figure 1. SREBP-1c activation mechanisms during a fasting-refeeding period...

... 4 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Alzheimer's disease pathology antiapoptotic antioxidative endoplasmic reticulum stress neuroprotective streptozotocin Alzheimer's disease (AD) is the most common...

... on behalf of the Biochemical Society 2020 endoplasmic reticulum stress paracrine renal physiology transmission unfolded protein response Adaptive responses to stress regulate both intrinsic and extrinsic cell functions [ 1 ]. Cellular extrinsic responses are involved in paracrine...

... by Portland Press Limited on behalf of the Biochemical Society 2018 calcium homoeostasis calcium imaging endoplasmic reticulum stress ryanodine receptors In many excitable cells, the cytosolic Ca 2+ signals generated by Ca 2+ entry through the plasma membrane are amplified by Ca 2+ release...

...-19b led to increased cell survival through up-regulation of the NFAT target gene encoding α-crystallin-B and repression of the pro-apoptotic gene Bim (Bcl-2-interacting mediator of cell death) under ER (endoplasmic reticulum) stress conditions. Taken together, the results of the present study...

...Bin Li; Zhenjun Pi; Lei Liu; Bi Zhang; Xiang Huang; Ping Hu; Eric Chevet; Ping Yi; Jianfeng Liu Induction of ER (endoplasmic reticulum) stress-mediated apoptosis in cancer cells represents an alternative approach for cancer therapy. Whether FGF-2 (fibroblast growth factor 2)-induced survival...

...) protects cells from the ER (endoplasmic reticulum) stress caused by severe hypoxia. Likewise, autophagy is a mechanism by which cancer cells can evade hypoxic cell death. In the present paper we report that the autophagy-initiating kinase ULK1 (UNC51-like kinase 1) is a direct transcriptional target...

...Fabrizio Damiano; Alessio Rochira; Romina Tocci; Simone Alemanno; Antonio Gnoni; Luisa Siculella A growing amount of evidence suggests the involvement of ER (endoplasmic reticulum) stress in lipid metabolism and in the development of some liver diseases such as steatosis. The transcription factor...

... 911 8 Tabas I. The role of endoplasmic reticulum stress in the progression of atherosclerosis Circ. Res. 2010 107 839 850 9 Linton M. F. Atkinson J. B. Fazio S. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation...

[email protected] ). 23 12 2011 1 3 2012 8 3 2012 8 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cisplatin endoplasmic reticulum stress GS28 p53 soluble N -ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE...

... Journal compilation © 2012 Biochemical Society 2012 breast cancer resistance protein (BCRP) Crohn's disease endoplasmic reticulum stress inflammatory bowel disease (IBD) ulcerative colitis unfolded protein response The intestinal epithelium is a single cell physical barrier between...

...Ebru Boslem; Gemma MacIntosh; Amanda M. Preston; Clarissa Bartley; Anna K. Busch; Maria Fuller; D. Ross Laybutt; Peter J. Meikle; Trevor J. Biden Saturated fatty acids promote lipotoxic ER (endoplasmic reticulum) stress in pancreatic β-cells in association with Type 2 diabetes. To address...

... of the mRNA for the transcription factor XBP1 (X-box-binding protein 1). The resulting XBP1s (spliced XBP1) can bind to an ERSE (endoplasmic-reticulum-stress-response-element), ERSE-II-like, that was identified within the Cat-1 promoter. Surprisingly, eIF2α phosphorylation is required for accumulation...

.... It caused induction of iNOS (inducible NO synthase), translocation of the NADPH oxidase subunit phox47 from the cytoplasm to the membrane, production of ROS (reactive oxygen species), and induction of ER (endoplasmic reticulum) stress markers HSP40 (heat-shock protein 40), PDI (protein disulfide-isomerase...

... ). 13 7 2009 14 8 2009 18 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 adiponectin Dsb endoplasmic reticulum stress inflammation insulin peroxisome-proliferator-activated receptor γ (PPARγ) transcription factor Adiponectin, a 30-kDa...

... that conditions of ER (endoplasmic reticulum) stress stimulate LD formation in Saccharomyces cerevisiae . We found that LDs accumulated in yeast mutants with compromised protein glycosylation or ER-associated protein degradation. Moreover, tunicamycin and Brefeldin A, agents which induce ER stress, were found...

... (email [email protected] or [email protected] ). detergent-resistant membrane endoplasmic reticulum stress glycosylation nuclear factor-erythroid 2 p45 subunit-related factor 1 (Nrf1) nuclear envelope oxidative stress transcriptional regulation Immunocytochemistry...

...Altin Gjymishka; Nan Su; Michael S. Kilberg The UPR (unfolded protein response) pathway comprises three signalling cascades mediated by the ER (endoplasmic reticulum) stress-sensor proteins PERK [PKR (double-stranded RNA-activated protein kinase)-like ER kinase], IRE1 (inositol-requiring kinase 1...

... such as plasmids, promoter reporter analyses and caspase 3/7 activity determination have been described recently [ 18 ]. apoptosis calcium calpain endoplasmic reticulum stress gene regulation paraoxonase Upon synthesis, all proteins destined for transmembrane insertion or secretion translocate...

... (endoplasmic reticulum) stress. Indeed, MTA treatment resulted in increased expression ER stress markers. In conclusion, SAM and MTA down-regulate BHMT expression in HepG2 cells in part by inducing NF-κB, which acts as a repressor for the human BHMT gene. While SAM's mechanism is NF-κB-dependent, MTA has both...