... been found to modulate endothelial functions. In the present study, we show that cocaine dramatically inhibits store-operated Ca 2+ entry (SOCE), a Ca 2+ influx mechanism promoted by depletion of intracellular Ca 2+ stores, in rat brain microvascular endothelial cells (RBMVEC). Using either Sig-1R...

... that interact with the ECM. The aim of the present study was to investigate the effect of peroxynitrous acid, an oxidant generated by activated macrophages, on the structure and function of the ECM laid down by HCAECs (human coronary artery endothelial cells) in vitro and in vivo . We show that exposure...

..., and found shedding of five previously unreported substrates [Kitl1, VE-cadherin (vascular endothelial cadherin), Flk-1 (fetal liver kinase 1), Tie-2, and VCAM-1 (vascular cell adhesion molecule 1)], of which the latter four are specifically expressed by endothelial cells. We also observed that ADAM12...

...(a), contains tandem repeats of a plasminogen kringle (K) IV-like domain. In the light of recent studies suggesting that apo(a)/Lp(a) affects endothelial function, we evaluated the effects of apo(a)/Lp(a) on growth and migration of cultured HUVECs (human umbilical-vein endothelial cells). Two full-length r-apo...

..., in cancers. Mechanisms controlling T-cad expression are poorly understood. The present study investigated transcriptional regulation of T-cad in ECs (endothelial cells). Conditions of oxidative stress (serum-deprivation or presence of H 2 O 2 ) elevate T-cad mRNA and protein levels in ECs. Reporter gene...

... into the extracellular milieu. The binding of bFGF to a tumour or endothelial cell-surface receptor can stimulate cell growth, migration and other biological events through signal transduction cascades. 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed...

...Richard J. Fish; Hong Yang; Christelle Viglino; Raoul Schorer; Sylvie Dunoyer-Geindre; Egbert K. O. Kruithof Regulated secretion of EC (endothelial cell) vWF (von Willebrand factor) is part of the haemostatic response. It occurs in response to secretagogues that raise intracellular calcium or cAMP...

... for signal transduction and activator of transcription) by low oxygen in microvascular endothelial cells. This activation appears to occur downstream of VEGF (vascular endothelial growth factor), a well-known proangiogenic factor, and is related to repression of proapoptotic FAS(CD95)/FASL(CD95L...

...Nobuyuki Marui; Russell M. Medford; Mushtaq Ahmad In vascular endothelial cells, cytokines induce genes that are expressed in inflammatory lesions partly through the activation of transcription factor NF-κB (nuclear factor-κB). Among the members of the NF-κB/rel protein family, homodimers...

... (cytosolic phospholipase A 2 ) that synthesize two essential factors for vascular wall integrity, NO (nitric oxide) and arachidonic acid. In endothelial cells from human umbilical vein cords, both 7-oxocholesterol (150 µM) and LPC (20 µM) decreased histamine-induced NO release, but not the release activated...

...Atsushi MITSUMOTO; Kwi-Ryeon KIM; Genichiro OSHIMA; Manabu KUNIMOTO; Katsuya OKAWA; Akihiro IWAMATSU; Yasuhito NAKAGAWA To clarify the molecular mechanisms of nitric oxide (NO) signalling, we examined the NO-responsive proteins in cultured human endothelial cells by two-dimensional (2D) PAGE...

..., heparan sulphate proteoglycan; PMS, phenazine methosulphate ; G3P, glyceraldehyde 3-phosphate ; HUVEC, human umbilical vein endothelial cell ; DMEM, Dulbecco s minimum essential medium; FBS, fetal bovine serum; MTS, T3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H...