...; published by Portland Press Limited 2016 Atheroprotection mediated by high-density lipoproteins could also be related to their ability to inhibit the expression of tissue factor, the main activator of the coagulation cascade, in endothelial cells and in monocytes. endothelium high-density...

... to the activity of KNP is shown to be negligible as both KNP and Helix elicit equipotent endothelium-dependent vasorelaxation. Further, KNP and Helix signalled through endothelial nitric oxide (NO) to mediate NPR-independent vasodilation. Thus, KNP exhibits non-canonical characteristics through its C-terminal...

... metabolism in vitro and in vivo . Hypoxia inhibited DDAH1 and DDAH2 expression and increased ADMA levels in cultured human pulmonary endothelial cells. In contrast, in human pulmonary smooth muscle cells, only DDAH2 was reduced whereas ADMA levels remained unchanged. Endothelium-specific down-regulation...

... transport in complex I, and this was associated with decreased expression of complex I subunits. Previous studies by this group demonstrated that shRNA depletion of Nox4, the major NADPH oxidase in endothelium, caused a shift from the senescent phenotype to one with a significant extension...

... The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cytoprotection endothelium inflammation protein kinase C (PKC) Generation and use of the adenoviral vectors expressing CA (constitutively active) and DN (dominant-negative) PKCϵ, βGal (β-galactosidase), Ad0 (control...

... correspondence should be addressed (email: [email protected] ). 21 12 2010 24 2 2011 28 2 2011 28 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium inflammation oxidative stress peroxiredoxin sepsis thioredoxin Sepsis...

..., distribution and reproduction in any medium, provided the original work is properly cited. angiogenesis CRT5 inhibitor endothelium protein kinase C (PKC) protein kinase D (PKD) vascular endothelial growth factor (VEGF) PKDs (Protein kinase Ds) are DAG (diacylglycerol)-stimulated serine...

... atmosphere of 95% air/5% CO 2 (v/v) at 37 °C. endothelial nitric oxide synthase (eNOS) endothelium insulin nitric oxide phosphorylation protein kinase B (PKB) signalling Type 2 diabetes is associated with a greatly increased risk of atherosclerosis, yet the molecular mechanisms...

... (Hewlett-Packard) and bands were quantified using Molecular Analyst (version 1.4, Bio-Rad Laboratories). endothelium extracellular-signal-regulated kinase 1/2 (ERK-1/2) nitric oxide synthase pregnancy vascular endothelial growth factor receptor 1 (VEGFR-1) VEGFR-2 To fully evaluate...

... activity was also found when primary bovine aortic endothelial cells were studied. These data imply that cell—cell contact induces the localization of eNOS at intercellular junctions, which is required for agonist-induced eNOS activation. endothelium endothelial permeability eNOS junctions...

...Lars M. RASMUSSEN; Peter R. HANSEN; Mehdi T. NABIPOUR; Ping OLESEN; Mikkel T. KRISTIANSEN; Thomas LEDET The expression of monocyte adhesion molecules, such as VCAM-1 (vascular cell adhesion molecule-1) and E-selectin, on the surface of the endothelium is an important step in the initiation...

... be involved in the mechanisms mediating VEGF-induced endothelial cell migration and anti-apoptosis. Key words: chemotaxis, endothelium, KDR, survival. several intracellular components, including p125 focal adhesion kinase (FAK) and paxillin [21,22]. The biological function(s) of signal transduction mechanisms...

... correspondence should be addressed (e-mail [email protected] ). 11 9 2000 8 11 2000 8 12 2000 The Biochemical Society, London © 2001 2001 apoptosis cytokine design endothelium structure Biochem. J. (2001) 354, 233 242 (Printed in Great Britain) 233 Anginex, a designed...

... to PGI 2 synthesis and suggest that the PKCδ isoform may be a key mediator of VEGF-induced activation of the ERK pathway via increased association with Raf-1. calcium endothelium MAP kinase nitric oxide phospholipase A2 Biochem. J. (2001) 353, 503 512 (Printed in Great Britain) 503 Vascular...

... South Huntington Avenue, Boston, MA 02130 (e-mail watkins.michael@;boston.va.gov). 22 6 1999 9 8 1999 10 9 1999 The Biochemical Society, London © 1999 1999 endothelium hypoxia. Biochem. J. (1999) 344, 747 754 (Printed in Great Britain) 747 Synthesis of 8-epi...

...Sue M. ANEMA; Simon W. WALKER; A. Forbes HOWIE; John R. ARTHUR; Fergus NICOL; Geoff J. BECKETT Damage to the endothelium by reactive oxygen species favours atherogenesis. Such damage can be prevented by selenium, which is thought to exert its actions through the expression of selenoproteins...

... whereby angiostatin- mediated regulation of plasmin formation could influence cellular migration and invasion. Key words: angiogenesis, a2-antiplasmin, endothelium, extra- cellular matrix, tissue-type plasminogen activator. solution phase, t-PA is an inefficient activator of plasminogen; however...