... disturbances of energy metabolism, as shown previously for the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) where oxidative modification of the sensitive catalytic cysteine residues induces nuclear translocation. As previously shown for cytosolic GAPDH, changed properties...

... detection. energy metabolism metastasis mitochondrial physiology OXPHOS Cancer cell metabolism is known to differ from that of normal cells. Therefore, those energy transduction peculiarities that are amenable to interference studies have been searched for in human tumours. Remodelling...

... with tandem mass tagging to provide precise, extensive coverage of S-glutathionylated targets in mouse liver. Critically, we show significant enrichment of S-glutathionylated mitochondrial and Krebs cycle proteins, identifying that S-glutathionylation is heavily involved in energy metabolism processes in vivo...

...-response elements of putative target genes involved in glucose metabolism, is expressed predominantly in skeletal muscle. We show that MondoA-knockout (KO) mice display enhanced capacity for glycolysis and sprinting, but not for endurance exercise. energy metabolism exercise fuel selection...

...; and (ii) to irreversibly damage proteins leading to loss or gain of function. Alzheimer’s disease Down's syndrome energy metabolism protein oxidation proteostasis network redox proteomics trisomy 21 Neurodegenerative disorders are a heterogeneous group of diseases of the nervous...

...Craig T. Armstrong; J. L. Ross Anderson; Richard M. Denton The regulation of the 2-oxoglutarate dehydrogenase complex is central to intramitochondrial energy metabolism. In the present study, the active full-length E1 subunit of the human complex has been expressed and shown to be regulated by Ca 2...

... in any medium, provided the original work is properly cited. cell death energy metabolism mitochondrion Src tyrosine kinase reactive oxygen species (ROS) Mitochondrial oxygen consumption was determined using a Clark-type oxygen electrode (Strathkelvin Instruments) as described...

... energy metabolism in rats with a sciatic nerve catheter that consists of two modules of reactions, ATP/PCr (phosphocreatine) supply and ATP/PCr demand, linked by the common intermediate PCr detected in vivo by 31 P-MRS (magnetic resonance spectroscopy). Measured system variables were [PCr] (intermediate...

... A 595 /min and converted into pmoles using a standard curve constructed from 0 to 40 pmol of appropriate pyridine nucleotide. Samples were corrected for volume and finally expressed as both μM pyridine nucleotide±S.D. and the NAD+/NADH ratio±S.D. cancer cytoprotection energy metabolism NADH...

... at a density of ~0.5×10 6 cells/well. All primary neurons and astrocytes were stained with Trypan Blue and counted before seeding into plates or dishes. astrocyte energy metabolism neurodegeneration neuron nitric oxide S-glutathionylation Excessive generation of NO • in neuroinflammation...

... indicating that there is a non-proteolytic mode of these interactions. Overall, it is tempting to hypothesize that by interacting with pro-invasive MT1-MMP, ANT plays a yet to be identified role in a coupling mechanism between energy metabolism and pericellular proteolysis in migrating cancer cells. 1...

.... 1 To whom correspondence should be addressed (email [email protected] ). 6 10 2006 24 11 2006 6 12 2006 6 12 2006 The Biochemical Society, London 2007 AMP-activated protein kinase (AMPK) Ca 2+ /calmodulin-dependent protein kinase kinase (CaMKK) energy...

... 6 2002 1 7 2002 1 7 2002 The Biochemical Society, London ©2002 2002 brain creatine kinase energy metabolism glial cell myelin basic protein transcription Abbreviations used: CGN, cerebellar granular neuron; CK, creatine kinase; CKB, brain creatine kinase; EMSA...

... Society, London ©2002 2002 cultured cells energy metabolism NADPH oxidative stress pentose phosphate pathway Abbreviations used: BCNU, 1,3-bis-(2-chloroethyl)-1-nitrosourea; BSO, buthionine sulphoximine; 2dGlc, 2-deoxyglucose; 2dGlc6P, 2-deoxyglucose 6-phosphate; DHEA...

... are differentially regulated in response to LPL-mediated NEFA uptake in skeletal muscle of mice. 1 To whom correspondence should be addressed. 27 11 2000 16 1 2001 14 2 2001 The Biochemical Society, London © 2001 2001 brown adipose tissue energy metabolism induced mutant mice...

... adipocyte. adipocyte energy metabolism mitochondria transcription vitamin A Biochem. J. (2000) 345, 91 97 (Printed in Great Britain) 91 Both retinoic-acid-receptor- and retinoid-X-receptor-dependent signalling pathways mediate the induction of the brown-adipose-tissue-uncoupling- protein-1 gene...

... sequence energy metabolism enzymology human mitochondria Biochem. J. (1999) 341, 777 784 (Printed in Great Britain) 777 Cytological evidence that the C-terminus of carnitine palmitoyltransferase I is on the cytosolic face of the mitochondrial outer membrane Feike R. VAN DER LEIJ*1, Anita M. KRAM...