... promote tumor growth and metastasis. Emphasis has been given to the re-organization of enhancers, essential regulatory elements controlling oncogenic gene expression, commonly marked my histone 3 lysine 4 monomethylation (H3K4me1). H3K4me1 is typically deposited by histone lysine methyltransferases (KMTs...

...Jenny L. Kerschner; Ann Harris A critical cis -regulatory element for the CFTR (cystic fibrosis transmembrane conductance regulator) gene is located in intron 11, 100 kb distal to the promoter, with which it interacts. This sequence contains an intestine-selective enhancer and associates...

... initiation. 1 To whom correspondence should be addressed (email [email protected] ). 1 6 2011 23 6 2011 28 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 allosteric pathway allosteric propagation allostery enhancer mediator transcription...

... for the islet-specific expression of Slc30a8 . VISTA analyses identified two conserved regions in Slc30a8 introns 2 and 3, designated enhancers A and B respectively. Transfection experiments demonstrated that enhancer B confers elevated fusion gene expression in both βTC-3 cells and αTC-6 cells. In contrast...

...Onard J. L. M. SCHONEVELD; Ingrid C. GAEMERS; Atze T. DAS; Maarten HOOGENKAMP; Johan RENES; Jan M. RUIJTER; Wouter H. LAMERS The GRU (glucocorticoid-response unit) within the distal enhancer of the gene encoding carbamoyl-phosphate synthase, which comprises REs (response elements) for the GR...

...Judy M. COULSON; Jodie L. EDGSON; Zoe V. MARSHALL-JONES; Robert MULGREW; John P. QUINN; Penella J. WOLL We have described previously a complex E-box enhancer (-147) of the vasopressin promoter in small-cell lung cancer (SCLC) extracts [Coulson, Fiskerstrand, Woll and Quinn, (1999) Biochem. J. 344...

...Shigeru TAKAHASHI; Naomi MATSUURA; Takako KUROKAWA; Yuji TAKAHASHI; Takashi MIURA We reported previously that the 5′-flanking region (nucleotides −1976 to −1655) of the human haem oxygenase-1 ( hHO-1 ) gene enhances hHO-1 promoter activity in human hepatoma HepG2 cells, but not in HeLa cells...

... on plastic, the phenotype recovery was incomplete or did not occur. The activity of a gene reporter construct containing the promoter and enhancer from the human type-II collagen gene ( COL2A1 ) was modulated by the culture conditions, so that its transcriptional activity was repressed in monolayer cultures...

... The Biochemical Society, London © 2000 2000 enhancer gene initiator TATA box transcription Biochem. J. (2000) 346, 233 240 (Printed in Great Britain) 233 Regulation of the juvenile hormone esterase gene by a composite core promoter Grace JONES*1,2, Yan Xia CHU*, Douglas SCHELLING* and Davy JONES‹2...

... driven by specific and non-specific enhancers. High-level expression of the mouse ITF gene specifically in intestinal goblet cells may be achieved through the combined effects of these regulatory elements. 1 To whom correspondence should be addressed ( [email protected]...

..., and that a strong enhancer was present within 601 bp of the 5ʹ-promoter region. In particular, the region from nt -233 to -34 significantly induced PLAP activity in the cell lines derived from various tissues and in the primary culture cells of rat brown adipose tissue, suggesting that this region is most important...