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Keywords: enzymatic assay
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Articles

1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors

Flaminia Mazzone, Astrid Hoeppner, Jens Reiners, Christoph G.W. Gertzen, Violetta Applegate, Mona A. Abdullaziz, Julia Gottstein, Daniel Degrandi, Martina Wesemann, Thomas Kurz, Sander H.J. Smits, Klaus Pfeffer
Journal: Biochemical Journal
Biochem J (2024) 481 (16): 1075–1096.
https://doi.org/10.1042/BCJ20240110
Published: 21 August 2024
...-infective crystal structure DXR DXR inhibitors enzymatic assay fosmidomycin growth inhibition parasite SAXS Toxoplasma gondii Toxoplasma gondii , the causative agent of toxoplasmosis, is an obligate coccidian parasite member of the phylum Apicomplexa [ 1 ]. As all apicomplexans, T...
View articletitled, 1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors
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Includes: Supplementary data
Articles

First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay

Judith Elkaim, Michel Castroviejo, Driss Bennani, Said Taouji, Nathalie Allain, Michel Laguerre, Jean Rosenbaum, Jean Dessolin, Patrick Lestienne
Journal: Biochemical Journal
Biochem J (2012) 443 (2): 549–559.
https://doi.org/10.1042/BJ20111779
Published: 27 March 2012
... Society 2012 ATPase activity enzymatic assay Pontin small-molecule inhibitor TATA-box-interacting protein 49 (TIP49) Vina virtual screening Pontin, also known as TIP (TATA-box-binding protein) 49 or RUVBL (RuvB-like) 1, and its homologue Reptin (TIP48, RUVBL2), with which it shares 40...
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Includes: Supplementary data
Articles

Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion

Bénédicte Mousson de camaret, Jan-Willem Taanman, Sylvie Padet, Maïté Chassagne, Martine Mayençon, Pascale Clerc-Renaud, Ginette Mandon, Marie-Thérèse Zabot, Alain Lachaux, Dominique Bozon
Journal: Biochemical Journal
Biochem J (2007) 402 (2): 377–385.
https://doi.org/10.1042/BJ20060705
Published: 12 February 2007
.... The residual DGUOK activity may play a crucial role in the phenotype reversal. deoxyguanosine kinase enzymatic assay mitochondrial DNA (mtDNA) depletion revertant phenotype skin fibroblast 1 To whom correspondence should be addressed (email [email protected] or benedicte.mousson-de...
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Includes: Supplementary data