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Keywords: enzyme activity
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Biochem J (2024) 481 (12): 759–775.
Published: 10 June 2024
..., with mutation of R145H/C and E161K impairing autoinhibition, and R635W enhancing autoinhibition. cancer enzyme activity protein kinase C theta signaling The novel protein kinase C (PKC) isozyme, PKC theta (θ), is most abundantly expressed in hematopoietic cells where it transduces signals...
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Biochem J (2020) 477 (6): 1179–1201.
Published: 27 March 2020
... enzyme activity FUT8 sialylation ST6GAL1 N- linked glycosylation is an important posttranslational process that regulates protein expression, folding, and bioactivity. Glycosylation reactions are catalyzed by various glycosyltransferases (GTases) such as α1,6-fucosyltransferase (FUT8...
Includes: Supplementary data
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Biochem J (2020) 477 (5): 953–970.
Published: 06 March 2020
... 2020 18 2 2020 18 2 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 catalysis enzyme activity fluorescence resonance energy transfer plasminogen streptokinase Human plasminogen (HPG), a single chain multi-domain...
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Biochem J (2019) 476 (20): 2939–2952.
Published: 18 October 2019
... enzymes exhibited high affinity for oxaloacetate and ATP, reinforcing their role as decarboxylases. We employed a high-throughput screening for putative allosteric regulators using differential scanning fluorometry and confirmed their effect on enzyme activity by performing enzyme kinetics. Ath PEPCK1...
Includes: Supplementary data
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Biochem J (2019) 476 (18): 2579–2594.
Published: 20 September 2019
...., Reistertown, MD 21136, U.S.A. 5 8 2019 27 8 2019 29 8 2019 29 8 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biosynthesis enzyme activity evolutionary biology genomics metabolism polyamines Cellular...
Includes: Supplementary data
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Biochem J (2018) 475 (20): 3275–3291.
Published: 31 October 2018
... and oxidation, and that these modifications regulate enzyme activity by preventing the formation of the active tetrameric form. The biotin-switch assay carried out on M1 and M2 isoforms showed that M2PYK is sensitive to nitrosation and that Cys326 is highly susceptible to redox modification. Structural...
Includes: Supplementary data
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Biochem J (2017) 474 (13): 2219–2233.
Published: 21 June 2017
... 2017 enzyme activity enzymology molecular evolution protein structure ribonuclease RNA Vertebrate animals possess a distinct, conserved family of secreted ribonucleases (RNases) not known to occur in any other taxon. This unique group of enzymes is termed the pancreatic-type RNases...
Includes: Supplementary data
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Biochem J (2009) 421 (1): 107–118.
Published: 12 June 2009
.... falciparum PRMT1) has authentic type I PRMT activity to form monomethylarginines and asymmetric dimethylarginines. Compared with mammalian PRMT1s, PfPRMT1 possesses a distinctive N-terminal sequence that is ∼50 amino acids longer and is essential for enzyme activity. Recombinant PfPRMT1 methylated histones...
Includes: Supplementary data
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Biochem J (2000) 352 (2): 251–255.
Published: 24 November 2000
... to the neuronal receptor [5]. The enzymic activity of PLA # neurotoxins is believed to be important in the later stage(s) of the process of presynaptic toxicity, although it does not correlate directly with their lethal potency [6]. Two receptors (R25 and R180, with apparent molecular masses of 25 and 180 kDa...
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Biochem J (2000) 349 (3): 813–819.
Published: 25 July 2000
... unique ligand binding properties, HSA also possesses an esterase-like activity, and studies with p -nitrophenyl acetate as a substrate showed that, although Arg-410 is important, the enzymic activity of HSA is much more dependent on the presence of Tyr-411. A minor activity could be registered when...
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Biochem J (2000) 345 (2): 351–356.
Published: 10 January 2000
... 10 9 1999 5 11 1999 The Biochemical Society, London © 2000 2000 enzyme activity fluorescent kinetic assay metallopeptidase Biochem. J. (2000) 345, 351 356 (Printed in Great Britain) 351 Development and characterization of novel potent and stable inhibitors of endopeptidase EC...
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Biochem J (1999) 341 (1): 139–145.
Published: 24 June 1999
..., which is 17 times less toxic. Two mutants of AtxA have been produced in bacteria and characterized. The specific enzymic activity of the K128 → E mutant on mixed phosphatidylcholine/Triton X-100 micelles is similar to that of the wild type. The K108 → N/K111 → N mutant, however, possesses 160...
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