... and identifies a promising mesotrypsin inhibitor as a starting point for the development of anticancer protein therapeutics. cancer therapy directed evolution enzyme inhibition mesotrypsin protease inhibitor protein engineering proteolysis X-ray structure The human serine protease...

... similarly calculated from eqns (4) and (5) respectively. (3) (4) (5) 3 5 2011 18 7 2011 2 8 2011 2 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 crystal structure drug discovery endopeptidase enzyme inhibition...

... 2010 20 7 2010 20 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 benzimidazole catecholamine drug discovery enzyme inhibition fragment-based screening phenylethanolamine N-methyltransferase (PNMT) The identification of suitable starting...

... kinetics enzyme inhibition kynurenic acid tryptophan metabolism Many xenobiotics and endogenous compounds such as neurotransmitters and steroid and thyroid hormones are metabolized through sulfate conjugation, which is catalysed by a family of SULTs (cytosolic sulfotransferases). The enzymes...

... that occupies the glycan binding site of PI-PLC, from where, depending on the substrate, it inhibits catalysis allosterically or competitively. Key words: covalent modification, enzyme inhibition, GPI. Cys-80!Ala mutant remains active, but is highly resistant to inactivation by pCMPS [15]. Coupled with the fact...

... relationship between the ester of the acyl-enzyme complex, the side chain of His-57 and the incoming nucleophile during the reversible (de)acylation steps, implying it is closely analogous to the hydrolytic deacylation step during catalytic peptide hydrolysis. Key words: enzyme inhibition, b-lactam, serine...

... 2000 2000 enzyme inhibition herbicide resistance site-directed mutagenesis valine resistance Biochem. J. (2000) 350, 69 73 (Printed in Great Britain) 69 Mutagenesis studies on the sensitivity of Escherichia coli acetohydroxyacid synthase II to herbicides and valine Yu-Ting LEE and Ronald G...