... been proposed to result from chemistry, specifically C-F bond strength, or biology, largely negative selection from fluoride toxicity. Given natural evolution has many hurdles, this review advocates for a strategy of laboratory engineering and evolution. Enzymes identified to participate...

... relationship to related pathologies, such as diabetes. In order to gain insight into the regulation of glucose metabolism, we studied the liver-expressed isoforms aldolase B and fructose-1,6-bisphosphatase-1 (FBPase-1), key enzymes in gluconeogenesis, analysing their cellular localization in hepatocytes under...

... microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer...

...Martin GRIFFIN; Rita CASADIO; Carlo M. BERGAMINI Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the post-translational modification of proteins by the formation of isopeptide bonds. This occurs either through protein cross-linking via ∊-(γ-glutamyl)lysine bonds...

...Karim MEHDI; Jacques THIERIE; Michel J. PENNINCKX In the yeast Saccharomyces cerevisiae , the enzyme γ-glutamyl transpeptidase (γ-GT; EC 2.3.2.2) is a glycoprotein that is bound to the vacuolar membrane. The kinetic parameters of GSH transport into isolated vacuoles were measured using intact...

... considered: (a) the conventional two-step model of enzyme catalysis, where the preparation contains only active catalyst (E a ) and inert (i.e. non-binding, non-catalytic) material (E i ); (b) an extension of the conventional model (a) involving only E a and E i , but with non-productive binding to E...

... 1999 The Biochemical Society, London © 1999 1999 enzymes Homo sapiens lipid metabolism monosaturated fatty acid, oleic acid Biochem. J. (1999) 340, 255 264 (Printed in Great Britain) 255 Human stearoyl-CoA desaturase : alternative transcripts generated from a single gene by usage...