... EGFR expression through transcriptional repression of Egfr by p27 Kip1 via the JNK/c-Jun cascade. bladder cancer c-Jun N-terminal kinase (JNK)/c-Jun pathway epidermal growth factor receptor (EGFR) p27 Kip1 signal transduction pathway Immortalized p27 Kip1+/+ and p27 Kip1−/− MEF...

... development. FRET and SpIDA (spatial intensity distribution analysis) show that Robo1 is predominantly dimeric through contacts between both extracellular and cytosolic domains, in the absence or presence of Slit2. epidermal growth factor receptor (EGFR) FRET receptor structure–function Roundabout...

... Biochemical Society 2013 activation aggregation dimer epidermal growth factor receptor (EGFR) fibril kinetics Samples of 1 mM Peptide C in water, 20 mM NaCl or assay buffer (15 mM Tris, pH 7.5, 0.02% polysorbate 20 and 20 mM NaCl) were analysed by DLS at 25°C using a DynaPro Titan (Wyatt...

... work is properly cited. cancer epidermal growth factor receptor (EGFR) erlotinib gefitinib inhibitor molecular dynamics receptor tyrosine kinase (RTK) X-ray crystallography Activating mutations in the EGFR (epidermal growth factor receptor) are now well accepted as oncogenic...

... 8 2011 18 4 2012 3 5 2012 3 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 activated cell division cycle 42-associated tyrosine kinase (ACK1) auto-inhibition epidermal growth factor receptor (EGFR) epidermal growth factor receptor (EGFR...

... Journal compilation © 2012 Biochemical Society 2012 epidermal growth factor receptor (EGFR) epithelial–mesenchymal transition (EMT) gene induction signalling cross-talk tetraspanin transforming growth factor β1 (TGFβ1) The transcriptional activity of the TM4SF5 promoter region (−3.2...

... in vivo through PKN. © The Authors Journal compilation © 2011 Biochemical Society 2011 cytoplasmic linker protein of 170 kDa (CLIP-170) epidermal growth factor receptor (EGFR) kinase substrate phosphorylation consensus motif protein kinase C-related kinase (PRK) protein kinase N (PKN...

... compilation © 2011 Biochemical Society 2011 epidermal growth factor receptor (EGFR) homology modelling kinase activation molecular dynamics principal component analysis (PCA) Figure 1 ErbB kinases sequence and structure ( A ) Alignment of the four catalytic subdomains comprising...

... 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 epidermal growth factor receptor (EGFR) gene expression p38 mitogen-activated protein kinase (p38 MAPK) Ras oncogene tumorigenesis p38α MAPK (mitogen-activated protein kinase) is an ubiquitously...

... oligonucleotides were used separately at 10 nM concentration, or in combination at a total concentration of 10 nM. The AIP4 oligonucleotide was used at 50 nM and the AIP5 smartpool at a total concentration of 200 nM. Protein depletion was confirmed in each experiment by immunoblotting. epidermal growth factor...

... Society 2009 astroglial differentiation epidermal growth factor receptor (EGFR) glial fibrillary acidic protein (GFAP) neural progenitor cell phosphatidylglucoside (PtdGlc) sphingolipid The lipid raft hypothesis has had a wide impact on the field of biology and has provided profound...

... occurs during normal wound healing. 1 To whom correspondence should be addressed (email [email protected] ). 1 6 2006 6 7 2006 19 7 2006 19 7 2006 The Biochemical Society, London 2006 aquaporin-3 (AQP3) cell migration epidermal growth factor receptor (EGFR...

... be addressed (email [email protected] ). 15 2 2006 19 6 2006 24 7 2006 24 7 2006 The Biochemical Society, London 2006 CD82 epidermal growth factor receptor (EGFR) G D1a ganglioside microdomain Neu3 sialidase tetraspanin The plasma membrane is a dynamic highly...

... from Alexis Biochemicals (Lausen, Switzerland). [α- 32 P]GTP (3000 Ci/mmol) was from NEN Life Science Products (Brussels, Belgium). Glutathione–Sepharose and GammaBind–Sepharose were from Amersham Biosciences (Freiburg, Germany). epidermal growth factor receptor (EGFR) nucleotide exchange...

... for 10 min, and the protein concentration of the supernatant was measured with a BCA (bicinchoninic acid) protein assay (Pierce). autophosphorylation epidermal growth factor receptor (EGFR) gefitinib kinase inhibition tyrosine kinase EGFR [EGF (epidermal growth factor) receptor...

... downstream targets such as Gab1 (Grb2-associated binding protein 1) [ 7 ], Shc [Src homology 2 (SH2) domain and collagen containing protein] [ 8 ], and PLCγ-1 (phospholipase Cγ-1) [ 9 , 10 ]. autophosphorylation epidermal growth factor receptor (EGFR) ErbB receptor Michaelis–Menten receptor...

... signals at the level of Ras-GTP formation and Ras nucleotide exchange discriminates true mediatory signals from permissive activities that do not participate in signal relay. Hence, whereas pertussis toxin (PTX) treatment impairs stimulation of nucleotide exchange, epidermal growth factor receptor (EGFR...