... of TJ in the colonic epithelium. Furthermore, corticosterone administration induced JNK and c-Src activation, TJ disruption and protein thiol oxidation in colonic mucosa. The present study demonstrates that oxidative stress is a common signal in the mechanism of TJ disruption in the intestinal...

... MMTV integration site family, member 1)-inducible signalling pathway protein 2 (WISP-2) epithelium glucocorticoid mesenchyme oestrogen CCN5 mRNA expression has been reported to be overexpressed in cancerous cells of human breast tissue and in breast cancer cell lines characterized...

... (bicinchoninic acid) Protein Assay Reagent (Pierce)] and radioactivity measurements. concentrative nucleoside transporter 2 (CNT2) epithelium phosphorylation plasma membrane protein kinase CK2 sorting Saturation kinetics were monitored in cultured CHO-K1 cells either in Na + -containing or Na...

... be addressed (email [email protected] ). 5 5 2011 24 6 2011 7 7 2011 7 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apical targeting cholesterol epithelium hepatocyte lipid raft myelin and lymphocyte protein (MAL) According to the original...

... barrier function cell-cell adhesion epithelium phosphothreonine protein kinase Cζ (PKCζ) zona occludens 1 (ZO-1) Caco-2 cells (A.T.C.C.) were grown under standard cell culture conditions as described previously [ 13 , 26 ]. Cells were grown on polyester membranes in Transwell inserts (6.5 mm, 12...

... 8 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 barrier function cell–cell adhesion c-Src epithelium occludin phospho-threonine An important function of the epithelial tight junction is to form a barrier to the diffusion of pathogens, toxins...

... should be addressed (email [email protected] ). 28 2 2007 25 6 2007 9 7 2007 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 α-difluromethylornithine (DFMO) epithelium p130Cas polyamine Src tumour necrosis factor α (TNFα...

... studies showed that activation of MAPK by active Raf-1 in salivary gland epithelium [ 42 ] and by active Ras in MDCK (Madin–Darby canine kidney) cells [ 43 ] disrupt the TJ. Disruption of TJs by Ras is associated with a decrease in the levels of occludin [ 43 ], whereas Raf-1 decreases the expression...

... should be addressed (email [email protected] ). 18 3 2005 29 6 2005 28 7 2005 28 7 2005 The Biochemical Society, London 2005 caspase-3 α-difluoromethylornithine (DFMO) epithelium putrescine polyamine STAT3 Apoptosis in the intestinal epithelium...

... to be useful in probing biological functions of this protein in ocular tissue. Key words: aldehyde dehydrogenase 3A1 (ALDH3A1), cornea, epithelium, 4-hydroxy-2-nonenal, lipid peroxidation, stromal keratocyte. INTRODUCTION ALDH3A1 (aldehyde dehydrogenase 3A1) is a member of the ALDH superfamily, which consists...

..., histone H2A has extremely strong anti-microbial properties and could therefore help contribute to protection against bacterial invasion. anti-bacterial protein epithelium mucosal immunity nucleosome The Biochemical Society, London ©2002 2002 25 6 2002 2 8 2002 6 8 2002...

... adhesion, epithelium, paracellular per- meability, tight junction, tyrosine kinase. was associated with tyrosine phosphorylation of a wide spectrum of proteins [16]. The specific role of protein tyrosine phosphoryl- ation in the mechanism of the oxidative-stress-induced increase in paracellular...

... blocker. Moreover, RNA analysis (reverse-transcription PCR, Northern blotting and in situ hybridization) revealed a high expression of cyp7b1 mRNA in the rat prostate, restricted to the epithelium, suggesting that cyp7b1 catalyses oxysterol 7α-hydroxylation in the prostate gland. 1 To whom...

... of a short promoter sequence in the strict transcriptional control of VPAC1 expression during differentiation of human colon cancer Caco-2 cells. Key words: epithelium, intestine, PACAP, VIP. cellular domain is crucial for VIP binding and correct delivery of the receptor to the plasma membrane [9 11]. Other...

... ). The nucleotide sequence data reported will appear in GenBank Nucleotide Sequence Database under the accession number AF051339. 9 10 1998 4 4 1999 7 4 1999 The Biochemical Society, London © 1999 1999 colon enhancer epithelium promoter silencer Biochem. J. (1999) 341, 461 472...