...Erik A. Richter; Lykke Sylow; Mark Hargreaves The interaction between insulin and exercise is an example of balancing and modifying the effects of two opposing metabolic regulatory forces under varying conditions. While insulin is secreted after food intake and is the primary hormone increasing...

... exercise. Similar to its established effects in skeletal muscle, aerobic exercise induces many biochemical adaptations in WAT including mitochondrial biogenesis and browning. While past research has focused on the regulation of these biochemical processes, there has been renewed interest as of late given...

...Heather L. Petrick; Graham P. Holloway The decline in fat oxidation at higher power outputs of exercise is a complex interaction between several mechanisms; however, the influence of mitochondrial bioenergetics in this process remains elusive. Therefore, using permeabilized muscle fibers from mouse...

...Pierre-Andre Barbeau; Paula M. Miotto; Graham P. Holloway The mechanisms regulating oxidative phosphorylation during exercise remain poorly defined; however, key mitochondrial proteins, including carnitine palmitoyltransferase-I (CPT-I) and adenine nucleotide translocase, have redox-sensitive sites...

...David A. Hood; Liam D. Tryon; Heather N. Carter; Yuho Kim; Chris C.W. Chen Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is responsive to acute increases in contractile activity patterns (i.e. exercise) which initiate the signalling of a compensatory...

... weight at birth, exhibited normal growth and appeared to be healthy. However, they exhibited unique metabolic characteristics. MondoA −/− mice built up serum lactate and alanine levels and utilized fatty acids for fuel during exercise. Gene expression and promoter analysis suggested that MondoA...

...Kornelia Ellwanger; Christine Kienzle; Sylke Lutz; Zheng-Gen Jin; Maria T. Wiekowski; Klaus Pfizenmaier; Angelika Hausser Skeletal muscle responds to exercise by activation of signalling pathways that co-ordinate gene expression to sustain muscle performance. MEF2 (myocyte enhancer factor 2...

...Erik A. Richter; Neil B. Ruderman AMPK (AMP-activated protein kinase) is a phylogenetically conserved fuel-sensing enzyme that is present in all mammalian cells. During exercise, it is activated in skeletal muscle in humans, and at least in rodents, also in adipose tissue, liver and perhaps other...

...Ho-Jin Koh; Michael F. Hirshman; Huamei He; Yangfeng Li; Yasuko Manabe; James A. Balschi; Laurie J. Goodyear Exercise increases AMPK (AMP-activated protein kinase) activity in human and rat adipocytes, but the underlying molecular mechanisms and functional consequences of this activation...

... from muscle biopsies taken before and after 6 weeks of endurance exercise training ( n = 8) were analysed for UCR. To investigate the role of uncoupling protein 2 (UCP2) and UCP3 in UCR, the sensitivity of UCR to UCP-regulating ligands (non-esterified fatty acids and purine nucleotides) and UCP2...

... simultaneous recruitment of all major extra- and intra-muscular energy stores. 1 To whom correspondence should be addressed (e-mail [email protected] ). 10 2 2000 28 6 2000 3 8 2000 The Biochemical Society, London © 2000 2000 exercise glycogen phosphorylase lipolysis...

... 2000 2000 exercise insulin action metabolism signal transduction transport Biochem. J. (2000) 349, 775 781 (Printed in Great Britain) 775 Contraction inhibits insulin-stimulated insulin receptor substrate-1/2- associated phosphoinositide 3-kinase activity, but not protein kinase B...