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Biochem J (2021) 478 (21): 3827–3846.
Published: 09 November 2021
...Erik A. Richter; Lykke Sylow; Mark Hargreaves The interaction between insulin and exercise is an example of balancing and modifying the effects of two opposing metabolic regulatory forces under varying conditions. While insulin is secreted after food intake and is the primary hormone increasing...
Biochem J (2020) 477 (6): 1061–1081.
Published: 18 March 2020
... exercise. Similar to its established effects in skeletal muscle, aerobic exercise induces many biochemical adaptations in WAT including mitochondrial biogenesis and browning. While past research has focused on the regulation of these biochemical processes, there has been renewed interest as of late given...
Biochem J (2019) 476 (3): 547–558.
Published: 08 February 2019
...Heather L. Petrick; Graham P. Holloway The decline in fat oxidation at higher power outputs of exercise is a complex interaction between several mechanisms; however, the influence of mitochondrial bioenergetics in this process remains elusive. Therefore, using permeabilized muscle fibers from mouse...
Biochem J (2018) 475 (18): 2997–3008.
Published: 28 September 2018
...Pierre-Andre Barbeau; Paula M. Miotto; Graham P. Holloway The mechanisms regulating oxidative phosphorylation during exercise remain poorly defined; however, key mitochondrial proteins, including carnitine palmitoyltransferase-I (CPT-I) and adenine nucleotide translocase, have redox-sensitive sites...
Biochem J (2016) 473 (15): 2295–2314.
Published: 28 July 2016
...David A. Hood; Liam D. Tryon; Heather N. Carter; Yuho Kim; Chris C.W. Chen Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is responsive to acute increases in contractile activity patterns (i.e. exercise) which initiate the signalling of a compensatory...
Minako Imamura, Benny Hung-Junn Chang, Motoyuki Kohjima, Ming Li, Byounghoon Hwang, Heinrich Taegtmeyer, Robert A. Harris, Lawrence Chan
Biochem J (2014) 464 (1): 35–48.
Published: 23 October 2014
... weight at birth, exhibited normal growth and appeared to be healthy. However, they exhibited unique metabolic characteristics. MondoA −/− mice built up serum lactate and alanine levels and utilized fatty acids for fuel during exercise. Gene expression and promoter analysis suggested that MondoA...
Includes: Supplementary data
Kornelia Ellwanger, Christine Kienzle, Sylke Lutz, Zheng-Gen Jin, Maria T. Wiekowski, Klaus Pfizenmaier, Angelika Hausser
Biochem J (2011) 440 (3): 327–335.
Published: 28 November 2011
...Kornelia Ellwanger; Christine Kienzle; Sylke Lutz; Zheng-Gen Jin; Maria T. Wiekowski; Klaus Pfizenmaier; Angelika Hausser Skeletal muscle responds to exercise by activation of signalling pathways that co-ordinate gene expression to sustain muscle performance. MEF2 (myocyte enhancer factor 2...
Includes: Supplementary data
Biochem J (2009) 418 (2): 261–275.
Published: 11 February 2009
...Erik A. Richter; Neil B. Ruderman AMPK (AMP-activated protein kinase) is a phylogenetically conserved fuel-sensing enzyme that is present in all mammalian cells. During exercise, it is activated in skeletal muscle in humans, and at least in rodents, also in adipose tissue, liver and perhaps other...
Ho-Jin Koh, Michael F. Hirshman, Huamei He, Yangfeng Li, Yasuko Manabe, James A. Balschi, Laurie J. Goodyear
Biochem J (2007) 403 (3): 473–481.
Published: 12 April 2007
...Ho-Jin Koh; Michael F. Hirshman; Huamei He; Yangfeng Li; Yasuko Manabe; James A. Balschi; Laurie J. Goodyear Exercise increases AMPK (AMP-activated protein kinase) activity in human and rat adipocytes, but the underlying molecular mechanisms and functional consequences of this activation...
Biochem J (2000) 351 (3): 805–810.
Published: 24 October 2000
... from muscle biopsies taken before and after 6 weeks of endurance exercise training ( n = 8) were analysed for UCR. To investigate the role of uncoupling protein 2 (UCP2) and UCP3 in UCR, the sensitivity of UCR to UCP-regulating ligands (non-esterified fatty acids and purine nucleotides) and UCP2...
Biochem J (2000) 351 (1): 207–214.
Published: 26 September 2000
... simultaneous recruitment of all major extra- and intra-muscular energy stores. exercise glycogen phosphorylase lipolysis metabolism triglyceride 1 To whom correspondence should be addressed (e-mail H.Galbo@mfi.ku.dk ). 10 2 2000 28 6 2000 3 8 2000 The Biochemical...
Biochem J (2000) 349 (3): 775–781.
Published: 25 July 2000
... the major site for insulin-stimulated glucose disposal in the post- prandial period, whereas glucose is utilized as a source of energy during exercise. Although both insulin and contraction increase the translocation of GLUT4 to the plasma membrane, the precise mechanisms involved are not yet fully...