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Keywords: exosite
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Articles
Biochem J (2021) 478 (13): 2681–2696.
Published: 16 July 2021
... preferred amino acid sequences resulting in proteolysis, but some also use exosites to select and cleave important proteins efficaciously. Such exosites have been found in a few caspases, notably caspase-7 that has a lysine patch (K 38 KKK) that binds RNA, which acts as a bridge to RNA-binding proteins...
Articles
Biochem J (2021) 478 (10): 1999–2017.
Published: 28 May 2021
... proteasomal degradation pathway. Additionally, we identified 15 ubiquitination K-sites and demonstrated that Trp-binding to an exosite impeded its proteolytic degradation. Here, we further established autophagic-lysosomal degradation as an alternative back-up pathway for cellular hTDO degradation. In addition...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (1): 227–242.
Published: 10 January 2020
...Pierre-Marie Andrault; Preety Panwar; Dieter Brömme We have previously determined that the elastolytic activities of cathepsins (Cat) K and V require two exosites sharing the same structural localization on both enzymes. The structural features involved in the elastolytic activity of CatS have not...
Includes: Supplementary data
Articles
Biochem J (2015) 470 (3): 357–367.
Published: 04 September 2015
... heparin-binding serpin. Noteworthily, we observed vaspin as a remarkably thermostable serpin and found that Glu 379 and Arg 302 influence heat-induced polymerization. These structural and functional results reveal the mechanistic basis of how reactive centre loop sequence and exosite interaction in vaspin...
Includes: Supplementary data
Articles
Biochem J (2015) 465 (1): 163–173.
Published: 12 December 2014
... shared with human cathepsins V and S. Other members of the cysteine cathepsin family, which are structurally similar, do not exhibit significant collagen and elastin degrading activities. This raises the question of the presence of specific structural elements, exosites, that are required for these...
Includes: Supplementary data
Articles
Biochem J (2006) 396 (2): 355–362.
Published: 15 May 2006
..., Ireland. 2 To whom correspondence should be addressed (email philip_fay@urmc.rochester.edu ). 17 1 2006 23 2 2006 28 2 2006 28 2 2006 The Biochemical Society, London 2006 activated Protein C (APC) coagulation protein exosite Factor VIII P1 arginine...
Articles
Biochem J (2002) 363 (2): 411–416.
Published: 08 April 2002
... 2002 exosite recombinant protein serine protease Abbreviations used: FVII, Factor VII; FVIIa, activated FVII; FVII(a), FVII not fully converted into the two-chain form; FIXa, activated Factor IX; FXa, activated Factor X; FXIIa, activated Factor XII; PCPS, 75% (w/w) l -α...