...Haifeng Zhang; Shiyu Cui; Zhenghui Jing; Guodan Fu; Rong Liu; Wenbao Zhao; Liting Xu; Lei Yu; Yuhui Bai; Changsheng Lv; Min Wu; Yuan Wei; Liangming Li; Shuang Peng Exosomes are vital mediators for intercellular communications in the tumor microenvironment to accelerate colon cancer progression...

... of intercellular communication largely through the transfer of functional cargo such as proteins, messenger RNAs (mRNAs), microRNA (miRNAs), DNAs and lipids. EVs, especially exosomes and shed microvesicles, represent an important delivery medium in the tumour micro-environment through the reciprocal dissemination...

... into exosomes, which makes them very potent for down-modulating the NKG2D receptor in effector immune cells. Moreover, MICA*008 is not affected by viral immune evasion mechanisms that target other MICA alleles. In the present study, we demonstrate that MICA*008 acquires a GPI (glycosylphosphatidylinositol...

... is capable of degrading highly structured RNAs, the RNase II activity is impaired by the presence of secondary structures. RNase II and RNase R share structural properties and have a similar modular domain organization. The eukaryotic RNase II homologue, Rrp44/Dis3, is the catalytic subunit of the exosome...

.... By analysing L1 (CD171) and CD44 in ovarian carcinoma cells, we show in the present paper that the cleavage induced by ionomycin, APMA (4-aminophenylmercuric acetate) or MCD (methyl-β-cyclodextrin) is initiated in an endosomal compartment that is subsequently released in the form of exosomes. Calcium influx...

...Karine LAULAGNIER; Claude MOTTA; Safouane HAMDI; Sébastien ROY; Florence FAUVELLE; Jean-François PAGEAUX; Toshihide KOBAYASHI; Jean-Pierre SALLES; Bertrand PERRET; Christian BONNEROT; Michel RECORD Exosomes are small vesicles secreted from multivesicular bodies, which are able to stimulate...