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Keywords: exosomes
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Articles

Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability

Ravichandran Vignesh, Anita Sjölander, Ganesh Venkatraman, Suresh Kumar Rayala, Gopala Krishna Aradhyam
Journal: Biochemical Journal
Biochem J (2021) 478 (12): 2265–2283.
https://doi.org/10.1042/BCJ20210016
Published: 18 June 2021
... supernatants from tumor cells have significantly higher amounts of secreted calnuc compared to non-tumor cells, selectively packaged into exosomes. Exosomal calnuc is causal for epithelial–mesenchymal transition and atypical migration in non-tumor cells, which are key events in tumorigenesis and metastasis...
View article titled, Aberrant environment and PS-binding to calnuc C-terminal tail drives <span class="search-highlight">exosomal</span> packaging and its metastatic ability
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Includes: Supplementary data
Articles

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

Yubao Liu, Rui Zou, Zhen Wang, Chuanyang Wen, Fan Zhang, Fuqing Lin
Journal: Biochemical Journal
Biochem J (2018) 475 (22): 3629–3638.
https://doi.org/10.1042/BCJ20180675
Published: 28 November 2018
...Yubao Liu; Rui Zou; Zhen Wang; Chuanyang Wen; Fan Zhang; Fuqing Lin The present study was designed to explore whether exosomal lncRNA-KLF3-AS1 derived from human mesenchymal stem cells (hMSCs) can serve as a positive treatment for osteoarthritis (OA). hMSCs and MSC-derived exosomes (MSC-exo) were...
View article titled, <span class="search-highlight">Exosomal</span> KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis
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Includes: Supplementary data
Articles

Substrate-inactivated cyclooxygenase-2 is disposed of by exosomes through the ER–Golgi pathway

Esraa Saadi, Sharon Tal, Liza Barki-Harrington
Journal: Biochemical Journal
Biochem J (2018) 475 (19): 3141–3151.
https://doi.org/10.1042/BCJ20180530
Published: 12 October 2018
... that either overexpressed or endogenously induced COX-2 is secreted via exosomes through the endoplasmic reticulum–Golgi pathway. We further find that excretion of COX-2 is significantly enhanced by prolonged exposure to AA. Genetic or chemical inhibition of COX-2 enzymatic activity has no effect on its...
View article titled, Substrate-inactivated cyclooxygenase-2 is disposed of by <span class="search-highlight">exosomes</span> through the ER–Golgi pathway
Open the PDF for Substrate-inactivated cyclooxygenase-2 is disposed of by <span class="search-highlight">exosomes</span> through the ER–Golgi pathway in another window
Includes: Supplementary data