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Articles

The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms

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Awards

Jan Böhning, Abul K. Tarafder, Tanmay A.M. Bharat

Biochem J (2024) 481 (4): 245–263.

https://doi.org/10.1042/BCJ20210301

Published: 15 February 2024

... are embedded in a primarily self-produced extracellular matrix, which is a defining feature of all biofilms. The biofilm matrix is a complex, viscous mixture primarily composed of polymeric substances such as polysaccharides, filamentous protein fibres, and extracellular DNA. The structured arrangement...

View articletitled, The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms

Articles

Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome

Sylvain D. Vallet, Martin N. Davis, Anna Barqué, Ali H. Thahab, Sylvie Ricard-Blum, Alexandra Naba

Biochem J (2021) 478 (7): 1413–1434.

https://doi.org/10.1042/BCJ20200675

Published: 16 April 2021

...Sylvain D. Vallet; Martin N. Davis; Anna Barqué; Ali H. Thahab; Sylvie Ricard-Blum; Alexandra Naba The extracellular matrix (ECM) is a complex meshwork of proteins and an essential component of multicellular life. We have recently reported the characterization of a novel ECM protein, SNED1...

View articletitled, Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome

Includes: Supplementary data

Articles

Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc

Cindy C. Shu, Susan M. Smith, Christopher B. Little, James Melrose

Biochem J (2019) 476 (2): 225–243.

https://doi.org/10.1042/BCJ20180695

Published: 18 January 2019

... contributions to growth factor sequestration, stabilisation/delivery, and activation of receptors directing cellular proliferation, differentiation, and assembly of extracellular matrix. Perlecan HS/CS-mediated interactions promote extracellular matrix assembly/stabilisation and tissue functional properties...

View articletitled, Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc

Articles

The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated

Inderjeet Kaur, Salla Ruskamo, Jarkko Koivunen, Ritva Heljasvaara, Jarkko J. Lackman, Valerio Izzi, Ulla E. Petäjä-Repo, Petri Kursula, Taina Pihlajaniemi

Biochem J (2018) 475 (22): 3577–3593.

https://doi.org/10.1042/BCJ20180405

Published: 20 November 2018

..., the MUCL-C18 may also serve as a lubricant at cell–extracellular matrix interfaces. Correspondence: Taina Pihlajaniemi ( [email protected] ) 4 6 2018 28 9 2018 15 10 2018 16 10 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf...

View articletitled, The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated

Articles

Plant cell wall signalling and receptor-like kinases

Sebastian Wolf

Biochem J (2017) 474 (4): 471–492.

https://doi.org/10.1042/BCJ20160238

Published: 03 February 2017

...Sebastian Wolf Communication between the extracellular matrix and the cell interior is essential for all organisms as intrinsic and extrinsic cues have to be integrated to co-ordinate development, growth, and behaviour. This applies in particular to plants, the growth and shape of which is governed...

View articletitled, Plant cell wall signalling and receptor-like kinases

Articles

Comparative proteomic assessment of matrisome enrichment methodologies

Lukas Krasny, Angela Paul, Patty Wai, Beatrice A. Howard, Rachael C. Natrajan, Paul H. Huang

Biochem J (2016) 473 (21): 3979–3995.

https://doi.org/10.1042/BCJ20160686

Published: 27 October 2016

...Lukas Krasny; Angela Paul; Patty Wai; Beatrice A. Howard; Rachael C. Natrajan; Paul H. Huang The matrisome is a complex and heterogeneous collection of extracellular matrix (ECM) and ECM-associated proteins that play important roles in tissue development and homeostasis. While several strategies...

View articletitled, Comparative proteomic assessment of matrisome enrichment methodologies

Includes: Supplementary data

Articles

The arterial microenvironment: the where and why of atherosclerosis

Arif Yurdagul, Jr, Alexandra C. Finney, Matthew D. Woolard, A. Wayne Orr

Biochem J (2016) 473 (10): 1281–1295.

https://doi.org/10.1042/BJ20150844

Published: 11 May 2016

.... atherosclerosis extracellular matrix inflammation microenvironment shear stress Atherosclerosis is a lipid-driven chronic inflammatory disease of large and medium sized arteries, hinders arterial function and prevents adequate blood flow to target tissues. Lipid deposition in the arterial wall...

View articletitled, The arterial microenvironment: the where and why of atherosclerosis

Articles

New insights into the structure, assembly and biological roles of 10–12 nm connective tissue microfibrils from fibrillin-1 studies

Sacha A. Jensen, Penny A. Handford

Biochem J (2016) 473 (7): 827–838.

https://doi.org/10.1042/BJ20151108

Published: 29 March 2016

...Sacha A. Jensen; Penny A. Handford The 10–12 nm diameter microfibrils of the extracellular matrix (ECM) impart both structural and regulatory properties to load-bearing connective tissues. The main protein component is the calcium-dependent glycoprotein fibrillin, which assembles into microfibrils...

View articletitled, New insights into the structure, assembly and biological roles of 10–12 nm connective tissue microfibrils from fibrillin-1 studies

Articles

Manipulating Cx43 expression triggers gene reprogramming events in dermal fibroblasts from oculodentodigital dysplasia patients

Jessica L. Esseltine, Qing Shao, Tao Huang, John J. Kelly, Jacinda Sampson, Dale W. Laird

Biochem J (2015) 472 (1): 55–69.

https://doi.org/10.1042/BJ20150652

Published: 30 October 2015

..., along with RNAi and RNA activation (RNAa) approaches, we show that manipulating Cx43 expression triggers cellular gene reprogramming. Quantitative RT-PCR, Western blot and immunofluorescent analysis of ODDD patient fibroblasts show unusually high levels of extracellular matrix (ECM)-interacting proteins...

View articletitled, Manipulating Cx43 expression triggers gene reprogramming events in dermal fibroblasts from oculodentodigital dysplasia patients

Articles

Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells

Christine Y. Chuang, Georg Degendorfer, Astrid Hammer, John M. Whitelock, Ernst Malle, Michael J. Davies

Biochem J (2014) 459 (2): 313–322.

https://doi.org/10.1042/BJ20131471

Published: 28 March 2014

...Christine Y. Chuang; Georg Degendorfer; Astrid Hammer; John M. Whitelock; Ernst Malle; Michael J. Davies ECM (extracellular matrix) materials, such as laminin, perlecan, type IV collagen and fibronectin, play a key role in determining the structure of the arterial wall and the properties of cells...

View articletitled, Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells

Includes: Supplementary data

Articles

Collagen XXII binds to collagen-binding integrins via the novel motifs GLQGER and GFKGER

Daniela Zwolanek, Guido Veit, Johannes A. Eble, Donald Gullberg, Florence Ruggiero, Jyrki Heino, Markus Meier, Jörg Stetefeld, Manuel Koch

Biochem J (2014) 459 (1): 217–227.

https://doi.org/10.1042/BJ20130642

Published: 14 March 2014

... of cartilage. Furthermore, evidence for an interaction with collagen-binding integrins that may stabilize the integrity of the extracellular matrix at the myotendinous junction was found [ 3 , 3a ]. Integrins belong to the group of type I transmembrane receptors that mediate the interactions of cells...

View articletitled, Collagen XXII binds to collagen-binding integrins via the novel motifs GLQGER and GFKGER

Includes: Supplementary data

Articles

Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity

Giada Marino, Pitter F. Huesgen, Ulrich Eckhard, Christopher M. Overall, Wolfgang P. Schröder, Christiane Funk

Biochem J (2014) 457 (2): 335–346.

https://doi.org/10.1042/BJ20130196

Published: 20 December 2013

... and pathological processes, including remodelling of the extracellular matrix. In the genome of the annual plant Arabidopsis thaliana , five MMP-like proteins (At-MMPs) are encoded, but their function is unknown. Previous work on these enzymes was limited to gene expression analysis, and so far proteolytic...

View articletitled, Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity

Includes: Supplementary data

Articles

Extended interaction network of procollagen C-proteinase enhancer-1 in the extracellular matrix

Romain Salza, Franck Peysselon, Emilie Chautard, Clément Faye, Laura Moschcovich, Tali Weiss, Laure Perrin-Cocon, Vincent Lotteau, Efrat Kessler, Sylvie Ricard-Blum

Biochem J (2014) 457 (1): 137–149.

https://doi.org/10.1042/BJ20130295

Published: 10 December 2013

...Romain Salza; Franck Peysselon; Emilie Chautard; Clément Faye; Laura Moschcovich; Tali Weiss; Laure Perrin-Cocon; Vincent Lotteau; Efrat Kessler; Sylvie Ricard-Blum PCPE-1 (procollagen C-proteinase enhancer-1) is an extracellular matrix glycoprotein that can stimulate procollagen processing...

View articletitled, Extended interaction network of procollagen C-proteinase enhancer-1 in the extracellular matrix

Includes: Supplementary data

Articles

The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells

Olivia C. Probst, Evren Karayel, Nicole Schida, Elisabeth Nimmerfall, Elisabeth Hehenberger, Verena Puxbaum, Lukas Mach

Biochem J (2013) 451 (1): 91–99.

https://doi.org/10.1042/BJ20121422

Published: 14 March 2013

... of the Creative Commons Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cell migration extracellular matrix insulin-like growth...

View articletitled, The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells

Includes: Supplementary data

Articles

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

Linda Troeberg, Barbara Mulloy, Peter Ghosh, Meng-Huee Lee, Gillian Murphy, Hideaki Nagase

Biochem J (2012) 443 (1): 307–315.

https://doi.org/10.1042/BJ20112159

Published: 14 March 2012

... (tissue inhibitor of metalloproteinases)-3. In the present study we demonstrate that PPS mediates the formation of a high-affinity trimolecular complex with ADAMTS-5 and TIMP-3. A TIMP-3 mutant that lacks extracellular-matrix-binding ability was insensitive to this affinity increase, and truncated forms...

View articletitled, Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

Articles

Identification of binding partners interacting with the α1-N-propeptide of type V collagen

Sofie Symoens, Marjolijn Renard, Christelle Bonod-Bidaud, Delfien Syx, Elisabeth Vaganay, Fransiska Malfait, Sylvie Ricard-Blum, Efrat Kessler, Lut Van Laer, Paul Coucke, Florence Ruggiero, Anne De Paepe

Biochem J (2011) 433 (2): 371–381.

https://doi.org/10.1042/BJ20101061

Published: 22 December 2010

... proteins, including extracellular matrix proteins and proteins involved in collagen biosynthesis. Eleven interactions were confirmed by surface plasmon resonance and/or co-immunoprecipitation: α1(I)- and α2(I)-collagen chains, α1(VI)-, α2(VI)- and α3(VI)-collagen chains, tenascin-C, fibronectin, PCPE-1...

View articletitled, Identification of binding partners interacting with the α1-N-propeptide of type V collagen

Includes: Supplementary data

Articles

Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells

Clément Faye, Antonio Inforzato, Marine Bignon, Daniel J. Hartmann, Laurent Muller, Lionel Ballut, Bjorn R. Olsen, Anthony J. Day, Sylvie Ricard-Blum

Biochem J (2010) 427 (3): 467–475.

https://doi.org/10.1042/BJ20091594

Published: 14 April 2010

... binds to TG-2 with an affinity in the nanomolar range ( K d =6.8 nM). Enzymatic assays indicated that, in contrast with other extracellular matrix proteins, endostatin is not a glutaminyl substrate of TG-2 and is not cross-linked to itself by the enzyme. Two arginine residues of endostatin, Arg 27...

View articletitled, Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells

Includes: Supplementary data

Articles

N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan

Eriko Aoyama, Takako Hattori, Mitsuhiro Hoshijima, Daisuke Araki, Takashi Nishida, Satoshi Kubota, Masaharu Takigawa

Biochem J (2009) 420 (3): 413–420.

https://doi.org/10.1042/BJ20081991

Published: 27 May 2009

..., migration, adhesion and extracellular matrix production, and it is thus involved in many biological and pathological processes. In particular, CCN2/CTGF is essential for normal skeletal development. To identify CCN2/CTGF-interactive proteins capable of modulating its action in cartilage, we carried out...

View articletitled, N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan

Articles

Enzymatic cleavage specificity of the proα1(V) chain processing analysed by site-directed mutagenesis

Christelle Bonod-Bidaud, Mickaël Beraud, Elisabeth Vaganay, Frédéric Delacoux, Bernard Font, David J. S. Hulmes, Florence Ruggiero

Biochem J (2007) 405 (2): 299–306.

https://doi.org/10.1042/BJ20070051

Published: 27 June 2007

... extracellular matrix metalloproteinase procollagen proteolytic processing site-directed mutagenesis transient cell transfection Amino acid sequence analysis was performed by automated Edman degradation using an Applied Biosystems 473A protein sequencer. For N-terminal sequencing of the TSPN-1 released...

View articletitled, Enzymatic cleavage specificity of the proα1(V) chain processing analysed by site-directed mutagenesis

Articles

The molecular structure of human tissue type XV presents a unique conformation among the collagens

Jeanne C. Myers, Peter S. Amenta, Arnold S. Dion, Justin P. Sciancalepore, Chandrasekaran Nagaswami, John W. Weisel, Peter D. Yurchenco

Biochem J (2007) 404 (3): 535–544.

https://doi.org/10.1042/BJ20070201

Published: 29 May 2007

... 2007 basement membrane chondroitin sulfate extracellular matrix heparan sulfate proteoglycan rotary shadowing type XV collagen Two main sources of human type XV are umbilical cord and placenta ( Figure 2 ; also see [ 18 – 20 ]). Initial purification attempts using placenta...

View articletitled, The molecular structure of human tissue type XV presents a unique conformation among the collagens

Articles

Collagen pretzels revealed by electron microscopy

Karl Kadler

Biochem J (2007) 404 (3): e7.

https://doi.org/10.1042/BJ20070416

Published: 29 May 2007

... and X), anchoring filaments (collagen VII), beaded narrow-diameter microfibrils (e.g. collagen VI), and FACIT (fibril-associated collagens with interrupted triple helices) collagens that bind to the surfaces of collagen fibrils and provide binding sites for ECM (extracellular matrix) macromolecules...

View articletitled, Collagen pretzels revealed by electron microscopy

Articles

Degradation of extracellular matrix and its components by hypobromous acid

Martin D. Rees, Tane N. McNiven, Michael J. Davies

Biochem J (2007) 401 (2): 587–596.

https://doi.org/10.1042/BJ20061236

Published: 21 December 2006

...-minoglycan components of extracellular matrix (proteoglycans and hyaluronan) may localize the production of HOBr to these materials. It is shown in the present paper that the reaction of HOBr with glycosaminoglycans (heparan sulfate, heparin, chondroitin sulfate and hyaluronan) generates polymer-derived N...

View articletitled, Degradation of extracellular matrix and its components by hypobromous acid

Articles

Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan

Stephan Reitinger, Gerhard Thomas Laschober, Christine Fehrer, Brigitte Greiderer, Günter Lepperdinger

Biochem J (2007) 401 (1): 79–85.

https://doi.org/10.1042/BJ20060598

Published: 11 December 2006

... at neutral pH. The two active hyaluronidases are both bound to the cell surface via a glycosylphosphatidylinositol anchor. Furthermore, structural characteristics are discussed that are necessary for hyaluronidases in order to exhibit hyaluronan cleavage. extracellular matrix fertilization...

View articletitled, Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan

Articles

TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2

Wei-Man Wang, Gaoxiang Ge, N. H. Lim, Hideaki Nagase, Daniel S. Greenspan

Biochem J (2006) 398 (3): 515–519.

https://doi.org/10.1042/BJ20060630

Published: 29 August 2006

...Wei-Man Wang; Gaoxiang Ge; N. H. Lim; Hideaki Nagase; Daniel S. Greenspan ADAMTS-2 is an extracellular metalloproteinase responsible for cleaving the N-propeptides of procollagens I–III; an activity necessary for the formation of collagenous ECM (extracellular matrix). The four TIMPs (tissue...

View articletitled, TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2

Articles

Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris

Ulrike Giesübel, Benjamin Dälken, Hayat Mahmud, Winfried S. Wels

Biochem J (2006) 394 (3): 563–573.

https://doi.org/10.1042/BJ20050687

Published: 24 February 2006

... effect was dependent on enzymatic activity and could be reversed by removal of the protein, suggesting GrB-dependent cleavage of extracellular matrix components as the underlying mechanism. 1 To whom correspondence should be addressed (email [email protected] ). 27 4 2005 25 11...

View articletitled, Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris

Articles

Computational evidence for protein-mediated fatty acid transport across the sarcolemma

Mark W. J. M. Musters, James B. Bassingthwaighte, Natal A. W. van Riel, Ger J. van der Vusse

Biochem J (2006) 393 (3): 669–678.

https://doi.org/10.1042/BJ20050869

Published: 13 January 2006

... investigated the effects of a sarcolemma-associated albumin receptor and a hypothetical FA-TFPC on the kinetics of trans-sarcolemmal FA transport rates. The Biochemical Society, London 2006 extracellular matrix fatty acid membrane protein modelling plasma albumin To meet the energy...

View articletitled, Computational evidence for protein-mediated fatty acid transport across the sarcolemma

Articles

The shed ectodomain of type XIII collagen associates with the fibrillar fibronectin matrix and may interfere with its assembly in vitro

Marja-Riitta Väisänen, Timo Väisänen, Hongmin Tu, Päivi Pirilä, Raija Sormunen, Taina Pihlajaniemi

Biochem J (2006) 393 (1): 43–50.

https://doi.org/10.1042/BJ20051073

Published: 12 December 2005

... in vitro with a number of extracellular matrix proteins, e.g. Fn (fibronectin). In view of its strong binding to Fn, we examined in the present study whether the released soluble ectodomain can bind to the fibrillar Fn matrix under cell-culture conditions and, if so, influence its assembly. In this study...

View articletitled, The shed ectodomain of type XIII collagen associates with the fibrillar fibronectin matrix and may interfere with its assembly in vitro

Articles

Zebrafish ( Danio rerio ) matrilins: shared and divergent characteristics with their mammalian counterparts

Ya-Ping KO, Birgit KOBBE, Mats PAULSSON, Raimund WAGENER

Biochem J (2005) 386 (2): 367–379.

https://doi.org/10.1042/BJ20041486

Published: 22 February 2005

... respectively. Danio rerio (zebrafish) extracellular matrix matrilin von Willebrand factor A-like Extracellular matrices are made up by proteoglycans, collagens and non-collagenous proteins that combine in various supramolecular assemblies, giving the tissue its architecture and mechanical...

View articletitled, Zebrafish ( Danio rerio ) matrilins: shared and divergent characteristics with their mammalian counterparts

Articles

The ADAMTS metalloproteinases

Sarah PORTER, Ian M. CLARK, Lara KEVORKIAN, Dylan R. EDWARDS

Biochem J (2005) 386 (1): 15–27.

https://doi.org/10.1042/BJ20040424

Published: 08 February 2005

... (email [email protected] ). 15 3 2004 18 11 2004 19 11 2004 19 11 2004 The Biochemical Society, London 2005 aggrecanase angiogenesis extracellular matrix metalloproteinase proteoglycan tissue inhibitor of metalloproteinase (TIMP) Kuno et al. [ 1...

View articletitled, The ADAMTS metalloproteinases

Articles

Activation of PPARγ is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro

Shizhong ZHENG, Anping CHEN

Biochem J (2004) 384 (1): 149–157.

https://doi.org/10.1042/BJ20040928

Published: 09 November 2004

...Shizhong ZHENG; Anping CHEN During liver fibrogenesis, quiescent HSC (hepatic stellate cells) become active, a transformation that is associated with enhanced cell proliferation and overproduction of ECM (extracellular matrix). Inhibition of cell proliferation and induction of apoptosis...

View articletitled, Activation of PPARγ is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro

Articles

Polarized fibronectin secretion induced by adenosine regulates bacterial–epithelial interaction in human intestinal epithelial cells

Baljit WALIA, Florencia E. CASTANEDA, Lixin WANG, Vasantha L. KOLACHALA, Rahul BAJAJ, Jesse ROMAN, Didier MERLIN, Andrew T. GEWIRTZ, Shanthi V. SITARAMAN

Biochem J (2004) 382 (2): 589–596.

https://doi.org/10.1042/BJ20040021

Published: 24 August 2004

... of Salmonella typhimurium into cultured epithelial cells. In summary, we have shown for the first time that FN, a classic extracellular matrix protein, is secreted into the apical compartment of epithelial cells in response to adenosine. FN may be a critical host factor that modulates adherence and invasion...

View articletitled, Polarized fibronectin secretion induced by adenosine regulates bacterial–epithelial interaction in human intestinal epithelial cells

Articles

Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors

Markus-N. KRUSE, Christoph BECKER, Daniel LOTTAZ, Danny KÖHLER, Irene YIALLOUROS, Hans-Willi KRELL, Erwin E. STERCHI, Walter STÖCKER

Biochem J (2004) 378 (2): 383–389.

https://doi.org/10.1042/bj20031163

Published: 01 March 2004

... and Genetics, University of Münster, Schlossplatz 5, D-48143 Münster, Germany. 3 To whom correspondence should be addressed (e-mail [email protected] ). 31 7 2003 20 10 2003 31 10 2003 31 10 2003 The Biochemical Society, London ©2004 2004 astacin extracellular matrix...

View articletitled, Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors

Articles

ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein

Jennifer WESTLING, Paul E. GOTTSCHALL, Vivian P. THOMPSON, Amber COCKBURN, George PERIDES, Dieter R. ZIMMERMANN, John D. SANDY

Biochem J (2004) 377 (3): 787–795.

https://doi.org/10.1042/bj20030896

Published: 01 February 2004

... correspondence should be sent: Shriners Hospital, 12502 Pine Drive, Tampa, FL 33612, U.S.A. (e-mail [email protected] ). 16 6 2003 5 9 2003 15 10 2003 15 10 2003 The Biochemical Society, London ©2004 2004 ADAMTS aggrecanase extracellular matrix hippocampus neoepitope...

View articletitled, ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein

Articles

Characterization of a pseudoachondroplasia-associated mutation (His587 Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP)

Luitgard SPITZNAGEL, D. Patric NITSCHE, Mats PAULSSON, Patrik MAURER, Frank ZAUCKE

Biochem J (2004) 377 (2): 479–487.

https://doi.org/10.1042/bj20031179

Published: 15 January 2004

... spectroscopy) extracellular matrix multiple epiphyseal dysplasia thrombospondin Abbreviations used: COMP, cartilage oligomeric matrix protein; EBNA, Epstein–Barr nuclear antigen; ER, endoplasmic reticulum; MALDI-TOF, matrix-assisted laser-desorption ionization–time-of-flight; MED, multiple...

View articletitled, Characterization of a pseudoachondroplasia-associated mutation (His587 Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP)

Articles

Fragmentation of extracellular matrix by hypochlorous acid

Alan A. WOODS, Michael J. DAVIES

Biochem J (2003) 376 (1): 219–227.

https://doi.org/10.1042/bj20030715

Published: 15 November 2003

...Alan A. WOODS; Michael J. DAVIES The interaction of extracellular matrix with cells regulates their adhesion, migration and proliferation, and it is believed that damage to vascular matrix components is a factor in the development of atherosclerosis. Evidence has been provided for a role...

View articletitled, Fragmentation of extracellular matrix by hypochlorous acid

Articles

Fibrillin-1 and −2 contain heparin-binding sites important for matrix deposition and that support cell attachment

Timothy M. RITTY, Thomas J. BROEKELMANN, Claudio C. WERNECK, Robert P. MECHAM

Biochem J (2003) 375 (2): 425–432.

https://doi.org/10.1042/bj20030649

Published: 15 October 2003

...Timothy M. RITTY; Thomas J. BROEKELMANN; Claudio C. WERNECK; Robert P. MECHAM Fibrillin-1 and −2 are large modular extracellular matrix glycoproteins found in many vertebrate organ systems and are known to be key components of the elastic fibre. In the present study, we identify a new heparin...

View articletitled, Fibrillin-1 and −2 contain heparin-binding sites important for matrix deposition and that support cell attachment

Articles

The mouse matrix metalloproteinase, epilysin (MMP-28), is alternatively spliced and processed by a furin-like proprotein convertase

Sara A. ILLMAN, Jorma KESKI-OJA, William C. PARKS, Jouko LOHI

Biochem J (2003) 375 (1): 191–197.

https://doi.org/10.1042/bj20030497

Published: 01 October 2003

... in intact, healthy tissues suggests that this MMP functions in physiological tissue homoeostasis and turnover. Key words: alternative splicing, extracellular matrix, matrix metalloproteinase, proteolysis, tissue expression. INTRODUCTION The matrix metalloproteinases (MMPs) comprise a family of at least 21...

View articletitled, The mouse matrix metalloproteinase, epilysin (MMP-28), is alternatively spliced and processed by a furin-like proprotein convertase

Articles

Characterization of SMOC-2, a modular extracellular calcium-binding protein

Christian VANNAHME, Silke GÖSLING, Mats PAULSSON, Patrik MAURER, Ursula HARTMANN

Biochem J (2003) 373 (3): 805–814.

https://doi.org/10.1042/bj20030532

Published: 01 August 2003

... that SMOC-2 is a glycoprotein with a calcium- dependent conformation. Results from Northern blots and reverse transcription PCR revealed a widespread expression in many tissues. Key words: EF-hand, extracellular matrix, BM-40, osteonectin, SPARC. INTRODUCTION The BM-40 family of modular extracellular...

View articletitled, Characterization of SMOC-2, a modular extracellular calcium-binding protein

Articles

Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1

David BERRY, Zachary SHRIVER, Barbara NATKE, Chi-Pong KWAN, Ganesh VENKATARAMAN, Ram SASISEKHARAN

Biochem J (2003) 373 (1): 241–249.

https://doi.org/10.1042/bj20021760

Published: 01 July 2003

.../heparan sulphate-like glycosaminoglycans (HSGAGs), found both in the extracellular matrix and on the cell surface. HSGAGs affect FGF signalling by interacting with both the growth factor and the FGF receptor (FGFR). In this study we sought to investigate whether HSGAGs at the cell surface of bovine aortic...

View articletitled, Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1

Articles

The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein

George N. MARCHENKO, Natalia D. MARCHENKO, Alex Y. STRONGIN

Biochem J (2003) 372 (2): 503–515.

https://doi.org/10.1042/bj20030174

Published: 01 June 2003

... embryogenesis extracellular matrix glial tissue human genome matrix metalloproteinase-21 neuronal tissue Abbreviations used: APMA, 4-aminophenylmercuric acetate; EMSA, electrophoretic mobility-shift assay; GSK, glycogen synthase kinase; HRP, horseradish peroxidase; LEF-1, lymphoid enhancer factor...

View articletitled, The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein

Articles

Detection of HOCl-mediated protein oxidation products in the extracellular matrix of human atherosclerotic plaques

Alan A. WOODS, Stuart M. LINTON, Michael J. DAVIES

Biochem J (2003) 370 (2): 729–735.

https://doi.org/10.1042/bj20021710

Published: 01 March 2003

... myeloperoxidase (MPO). As MPO is released extracellularly by activated monocytes (and possibly macrophages) and is a highly basic protein, it would be expected to associate with polyanions such as the glycosaminoglycans of the extracellular matrix, and might result in damage being localized at such sites...

View articletitled, Detection of HOCl-mediated protein oxidation products in the extracellular matrix of human atherosclerotic plaques

Articles

Transglutaminases: Nature’s biological glues

Martin GRIFFIN, Rita CASADIO, Carlo M. BERGAMINI

Biochem J (2002) 368 (2): 377–396.

https://doi.org/10.1042/bj20021234

Published: 01 December 2002

... diseases extracellular matrix enzymes protein cross-links Abbreviations used: AD, Alzheimer disease; DN, diabetic nephropathy; LTBP-1, latent TGF (transforming growth factor)-β binding protein-1; PDB, SWISS-PROT Protein Knowledgebase; Tgase, transglutaminase; tTgase, type 2 tissue...

View articletitled, Transglutaminases: Nature’s biological glues

Articles

Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes

Gilles CROISSANDEAU, Michel CHRÉTIEN, Majambu MBIKAY

Biochem J (2002) 364 (3): 739–746.

https://doi.org/10.1042/bj20011158

Published: 15 June 2002

...Gilles CROISSANDEAU; Michel CHRÉTIEN; Majambu MBIKAY When mouse 3T3-L1 preadipocytes are induced to differentiate into adipocytes, they change from an extended fibroblast-like morphology to a rounded one. This change most likely occurs through extracellular matrix remodelling, a process known...

View articletitled, Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes

Articles

Mesangial cell gelatinase A synthesis is attenuated by oscillating hyperbaric pressure

Abdelaziz EN-NIA, Julia REISDORFF, Ioannis STEFANIDIS, Juergen FLOEGE, Peter C. HEINRICH, Peter R. MERTENS

Biochem J (2002) 362 (3): 693–700.

https://doi.org/10.1042/bj3620693

Published: 08 March 2002

... element extracellular matrix gene transcription pressure-responsive regulatory sequence signal transduction and activation of transcription factors Abbreviations used: AP, atmospheric pressure; AP-2, activating protein-2; CE, cytoplasmic extract; MC, mesangial cell; MMP, matrix...

View articletitled, Mesangial cell gelatinase A synthesis is attenuated by oscillating hyperbaric pressure

Articles

Structural and functional characterization of the human and mouse fibulin-1 gene promoters: role of Sp1 and Sp3

Mirco CASTOLDI, Mon-Li CHU

Biochem J (2002) 362 (1): 41–50.

https://doi.org/10.1042/bj3620041

Published: 08 February 2002

... membrane cardiovascular DNA binding extracellular matrix transcription Abbreviations used: AP-2, activator protein 2; EMSA, electrophoretic mobility-shift assay. Biochem. J. (2002) 362, 41 50 (Printed in Great Britain) 41 Structural and functional characterization of the human and mouse...

View articletitled, Structural and functional characterization of the human and mouse fibulin-1 gene promoters: role of Sp1 and Sp3

Articles

The fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribs

Sujata G. PANDIT, Prasanthi GOVINDRAJ, Joachim SASSE, Peter J. NEAME, John R. HASSELL

Biochem J (2002) 361 (2): 231–241.

https://doi.org/10.1042/bj3610231

Published: 08 January 2002

... the presence of full-length FGFR3 (135kDa) for both isoforms in the reserve zone, a major 98kDa fragment in all zones and smaller fragments primarily in the hypertrophic zone. Immunostaining localized FGFR3 to the pericellular region of reserve chondrocytes and to the extracellular matrix in the hypertrophic...

View articletitled, The fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribs

Articles

Cloning and expression of a novel UDP-GlcNAc:α-d-mannoside β1,2-N-acetylglucosaminyltransferase homologous to UDP-GlcNAc:α-3-d-mannoside β1,2-N-acetylglucosaminyltransferase I

Wenli ZHANG, Doron BETEL, Harry SCHACHTER

Biochem J (2002) 361 (1): 153–162.

https://doi.org/10.1042/bj3610153

Published: 17 December 2001

... proteins. Key words: cytoskeleton, a-dystroglycan, extracellular matrix, laminin, O-mannosylated protein. ed, e.g. UDP-Gal :GlcNAc-R b1,4-galactosyltransferases [11], UDP-Gal :GlcNAc-R b1,3-galactosyltransferases [11] and GDP- Fuc:Galb1-4GlcNAc-R (Fuc to GlcNAc) a1,3-fucosyltrans- ferases [12] (where R can...

View articletitled, Cloning and expression of a novel UDP-GlcNAc:α-d-mannoside β1,2-N-acetylglucosaminyltransferase homologous to UDP-GlcNAc:α-3-d-mannoside β1,2-N-acetylglucosaminyltransferase I

Articles

UDP-glucose pyrophosphorylase: up-regulation in hypertrophic cartilage and role in hyaluronan synthesis

Cordula MAGEE, Maria NURMINSKAYA, Thomas F. LINSENMAYER

Biochem J (2001) 360 (3): 667–674.

https://doi.org/10.1042/bj3600667

Published: 10 December 2001

... gene, UDPG-PPase, as well as the HAS genes. 1 To whom correspondence should be addressed (e-mail [email protected] ). 25 6 2001 7 9 2001 18 10 2001 The Biochemical Society, London ©2001 2001 chondrocyte extracellular matrix glycosaminoglycan hyaluronan...

View articletitled, UDP-glucose pyrophosphorylase: up-regulation in hypertrophic cartilage and role in hyaluronan synthesis

Articles

Ca2+/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan

Charlotte A. LEWIS, Paul A. TOWNSEND, Clare M. ISACKE

Biochem J (2001) 357 (3): 843–850.

https://doi.org/10.1042/bj3570843

Published: 25 July 2001

...Charlotte A. LEWIS; Paul A. TOWNSEND; Clare M. ISACKE CD44 is the principal cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and binding to this ligand underlies CD44-mediated cell attachment and migration. As would be expected for a widely expressed adhesion...

View articletitled, Ca2+/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan

Articles

Purification, molecular cloning and mechanism of action of graminelysin I, a snake-venom-derived metalloproteinase that induces apoptosis of human endothelial cells

Wen Bin WU, Shin C. CHANG, Ming-Yi LIAU, Tur-Fu HUANG

Biochem J (2001) 357 (3): 719–728.

https://doi.org/10.1042/bj3570719

Published: 25 July 2001

.... Similarly, its apoptosis-inducing activity was blocked if it was treated with EDTA. These results suggest that the catalytic activity of graminelysin I on matrix proteins contributes to its apoptosis-inducing activity. DNA fragmentation endothelial cell detachment extracellular matrix metalloprotease...

View articletitled, Purification, molecular cloning and mechanism of action of graminelysin I, a snake-venom-derived metalloproteinase that induces apoptosis of human endothelial cells

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