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Keywords: extracellular signal-regulated kinases
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Articles
In Collection
Cell signaling in the 21st century
Abhineet Ram, Devan Murphy, Nicholaus DeCuzzi, Madhura Patankar, Jason Hu, Michael Pargett, John G. Albeck
Journal:
Biochemical Journal
Biochem J (2023) 480 (23): 1887–1907.
Published: 01 December 2023
...Abhineet Ram; Devan Murphy; Nicholaus DeCuzzi; Madhura Patankar; Jason Hu; Michael Pargett; John G. Albeck Extracellular signal-regulated kinase (ERK) has long been studied as a key driver of both essential cellular processes and disease. A persistent question has been how this single pathway...
Articles
In Collection
Cell signaling in the 21st century
Abhineet Ram, Devan Murphy, Nicholaus DeCuzzi, Madhura Patankar, Jason Hu, Michael Pargett, John G. Albeck
Journal:
Biochemical Journal
Biochem J (2023) 480 (23): 1909–1928.
Published: 01 December 2023
...Abhineet Ram; Devan Murphy; Nicholaus DeCuzzi; Madhura Patankar; Jason Hu; Michael Pargett; John G. Albeck Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular processes, including cell division, death, and differentiation. In this second installment of a two...
Articles
A. Jane Bardwell, Madhuri Paul, Kiku C. Yoneda, María D. Andrade-Ludeña, Oanh T. Nguyen, David A. Fruman, Lee Bardwell
Journal:
Biochemical Journal
Biochem J (2023) 480 (10): 729–750.
Published: 26 May 2023
... agreement with UC. extracellular signal-regulated kinases intracellular signaling molecular scaffolds phosphoinositide 3-kinase Preliminary domain-mapping experiments indicated that the N-terminal adapter-binding domain (ABD) of p110α was sufficient for binding to the WW domain of IQGAP1 (data...
Articles
In Collection
Cell signaling in the 21st century
Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook
Journal:
Biochemical Journal
Biochem J (2023) 480 (9): 587–605.
Published: 04 May 2023
... effects of ERK1/2 and the therapeutic use of ERKi. ERK inhibitors extracellular signal-regulated kinases MEK RAF RAS ubiquitin proteasome system The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway drives cell survival, cell proliferation and differentiation in response to extracellular...
Includes: Supplementary data
Articles
Helen A. Brown, Charles A.C. Williams, Houjiang Zhou, Diana Rios-Szwed, Rosalia Fernandez-Alonso, Saria Mansoor, Liam McMulkin, Rachel Toth, Robert Gourlay, Julien Peltier, Nora Dieguez-Martinez, Matthias Trost, Jose M. Lizcano, Marios P. Stavridis, Greg M. Findlay
Journal:
Biochemical Journal
Biochem J (2021) 478 (23): 4119–4136.
Published: 06 December 2021
... BY) . embryonic stem cells extracellular signal-regulated kinases Kruppel-like transcription factors proteomics Embryonic Stem Cells (ESCs) can self-renew or differentiate along any lineage in the adult body, a property known as pluripotency [ 1 ]. The fundamental regulatory mechanisms which govern...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (6): 1303–1307.
Published: 23 March 2021
.... A recent study by Damasio et al. [ Biochem. J. (2021) 478 , 79–98. doi:10.1042/BCJ20200661] focuses on characterizing the effect of extracellular signal-regulated kinase (ERK) on the remodeling of the proteome of activated CD8+ T cells using Mass spectrometric analysis. Surprisingly, the Effector kinase...
Articles
Marcos P. Damasio, Julia M. Marchingo, Laura Spinelli, Jens L. Hukelmann, Doreen A. Cantrell, Andrew J.M. Howden
Journal:
Biochemical Journal
Biochem J (2021) 478 (1): 79–98.
Published: 13 January 2021
... key T cell signalling module is mediated by extracellular signal-regulated kinases (ERKs) which are activated in response to antigen receptor engagement. The activity of ERKs is often used to report antigen receptor occupancy but the full details of how ERKs control T cell activation is not understood...
Includes: Supplementary data