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Keywords: extracellular-signal-regulated kinase (ERK)
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Articles
CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins
Journal:
Biochemical Journal
Biochem J (2013) 454 (1): 109–121.
Published: 26 July 2013
... unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. early signalling complex extracellular-signal-regulated kinase (ERK) integrin outside-in signalling T-cell co-stimulation Integrins are critical for T-cell function, including T-cell...
Articles
Carolyn Bentley, Stefanie S. Jurinka, Noelyn M. Kljavin, Steffan Vartanian, Sree R. Ramani, Lino C. Gonzalez, Kebing Yu, Zora Modrusan, Pan Du, Richard Bourgon, Richard M. Neve, David Stokoe
Journal:
Biochemical Journal
Biochem J (2013) 452 (2): 313–320.
Published: 10 May 2013
... correspondence should be addressed (email [email protected] ). 15 10 2012 20 2 2013 18 3 2013 18 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Akt extracellular-signal-regulated kinase (ERK) GTPase Ras transformation zinc-finger nuclease...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 451 (1): 123–134.
Published: 14 March 2013
...-regulated kinase (ERK) human epidermal growth factor receptor 2 (HER2) Notch1 survivin Proteins in the IAP (inhibitor of apoptosis protein) family are vital in the blockade of apoptosis [ 1 ]. Survivin is the smallest IAP (16.5 kDa) containing a single baculovirus IAP-repeat domain [ 2...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 445 (2): 229–236.
Published: 27 June 2012
... in alveolar macrophages and highlight the importance of these proteins in pulmonary fibrosis. extracellular-signal-regulated kinase (ERK) macrophage matrix metalloproteinase 9 (MMP-9) pulmonary fibrosis Rac1 specificity protein 1 (SP-1) A hallmark of pulmonary fibrosis is aberrant matrix...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 443 (3): 643–653.
Published: 16 April 2012
... To whom correspondence should be addressed (email [email protected] ). 30 11 2011 30 1 2012 17 2 2012 17 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 compartmentalization extracellular-signal-regulated kinase (ERK) Golgi apparatus progestin...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 441 (2): 571–578.
Published: 21 December 2011
... To whom correspondence should be addressed (email [email protected] ). 16 5 2011 8 9 2011 27 9 2011 27 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) mitogen...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 51–63.
Published: 15 December 2010
... growth factor (EGF) extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase (MEK) occludin protein kinase Cζ (PKCζ) protein phosphatase 2A (PP2A) Epithelial tight junctions in the intestinal mucosa perform the critical...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 429 (2): 369–377.
Published: 28 June 2010
.... In the experiments with TXB 2 measurements, the treatment of PRP with acetylsalicylic acid was omitted. ADP Akt extracellular-signal-regulated kinase (ERK) phosphoinositide 3-kinase (PI3K) platelet thromboxane A 2 (TXA 2 ) Aggregation of 0.5 ml of washed platelets was analysed using a PICA...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 423 (2): 279–290.
Published: 25 September 2009
... Society 2009 eukaryotic initiation factor 4E (eIF4E) extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase signal-integrating kinase (Mnk) p38 mitogen-activated protein kinase (p38 MAPK) protein kinase The Mnks [MAPK (mitogen-activated protein kinase) signal...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 420 (3): 345–361.
Published: 27 May 2009
... (ALCL) extracellular-signal-regulated kinase (ERK) inflammatory myofibroblastic tumour (IMT) midkine neuroblastoma non-small cell lung cancer (NSLCL) pleiotrophin In mammals PTN (pleiotrophin) also known as HB-GAM (heparin-binding growth-associated molecule) [ 39 ], OSF-1 (osteoblast...
Articles
Madhurima Rajkhowa, Sandra Brett, Daniel J. Cuthbertson, Christopher Lipina, Antonio J. Ruiz-Alcaraz, Giles E. Thomas, Lisa Logie, John R. Petrie, Calum Sutherland
Journal:
Biochemical Journal
Biochem J (2009) 418 (3): 665–671.
Published: 25 February 2009
... studies. Most importantly, the molecular defect identified was independent of adiposity. The altered response of ERK to insulin in PCOS was the most obvious signalling defect associated with insulin resistance in muscle from these patients. extracellular-signal-regulated kinase (ERK) human muscle...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 417 (3): 705–715.
Published: 16 January 2009
... peptides using Hi-Trap columns (Amersham Biosciences) [ 25 ]. cross-talk extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) phosphorylation potassium channel protein kinase C (PKC) Regulation of transient outward K + currents in cardiac myocytes...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 417 (1): 331–342.
Published: 12 December 2008
... chemiluminescence) reaction for identification of the different proteins and their phosphorylated form were performed as described in Sambrook et al. [ 37 ] and by Yaakov et al. [ 38 ]. extracellular-signal-regulated kinase (ERK) c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) p38...
Includes: Supplementary data
Articles
Maria Perander, Espen Åberg, Bjarne Johansen, Bo Dreyer, Ingrid J. Guldvik, Heidi Outzen, Stephen M. Keyse, Ole-Morten Seternes
Journal:
Biochemical Journal
Biochem J (2008) 411 (3): 613–622.
Published: 14 April 2008
.... coli (BL21) and purified as previously described [ 8 ]. SDS/PAGE and Coomassie Blue staining were used to analyse both the expression and yield of the fusion proteins. 1 To whom correspondence should be addressed (email [email protected] ). extracellular-signal-regulated kinase (ERK...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 409 (1): 53–64.
Published: 11 December 2007
... 10 2007 1 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 cell growth inhibition extracellular-signal-regulated kinase (ERK) FXNPXY motif low-density lipoprotein receptor-related protein 1 (LRP1) mutational analysis tumorigenesis LRP1 [LDLR...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (3): e5.
Published: 13 July 2007
... (epidermal growth factor) receptor, which is in turn activated by the release of reactive oxygen species. 1 email [email protected] . 6 6 2007 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 extracellular-signal-regulated kinase (ERK) mitogen...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (3): 559–568.
Published: 13 July 2007
... out using either alkaline phosphatase (Promega) or ECL® (Amersham Biosciences) kits, according to the manufacturer's instructions. extracellular-signal-regulated kinase (ERK) heparin-binding epidermal growth factor (Hb-EGF) matrix metalloproteinase (MMP) mobile phone irradiation NADH...
Articles
Claire E. Mccoy, Andrew Macdonald, Nick A. Morrice, David G. Campbell, Maria Deak, Rachel Toth, Joanne Mcilrath, J. Simon C. Arthur
Journal:
Biochemical Journal
Biochem J (2007) 402 (3): 491–501.
Published: 26 February 2007
...-Dye Ver3.1 chemistry on a capillary sequencer. 2 8 2006 10 11 2006 22 11 2006 22 11 2006 The Biochemical Society, London 2007 cAMP-response-element-binding protein (CREB) extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) p38...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 401 (3): 689–699.
Published: 12 January 2007
... of extracellular-signal-regulated kinase (ERK). As a result, we observed increased expression levels and activity of matrix metalloproteinases-2 and -9, which correlated with decreased expression of integrins α1 and β1. Together these results suggest that the organization of crucial molecules in GEMs of MCF-7...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 400 (1): 135–141.
Published: 27 October 2006
... (email [email protected] ). apoptosis c-Jun N-terminal kinase (JNK) extracellular-signal-regulated kinase (ERK) glutathione S-transferase Alpha 1-1 (GSTA1-1) interleukin-1β (IL-β) oxidative stress Total RNA was isolated using TRIzol® reagent (Invitrogen, Burlington, ON, Canada...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 397 (2): 329–336.
Published: 28 June 2006
... be addressed (email [email protected] ). 16 12 2005 13 3 2006 29 3 2006 29 3 2006 The Biochemical Society, London 2006 extracellular-signal-regulated kinase (ERK) H-Ras nitric oxide synthase (NOS) S-nitrosylation NO • is enzymatically formed by NOSs...
Articles
Richard J. Orton, Oliver E. Sturm, Vladislav Vyshemirsky, Muffy Calder, David R. Gilbert, Walter Kolch
Journal:
Biochemical Journal
Biochem J (2005) 392 (2): 249–261.
Published: 22 November 2005
... 2005 computational modelling extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) receptor tyrosine kinase signalling network systems biology In molecular biology the MAPK (mitogen-activated protein kinase) pathway is considered to be a paradigm...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 391 (1): 143–151.
Published: 26 September 2005
... that SHP2 bound to Gab1 in EGF (epidermal growth factor)-stimulated cells to mediate ERK activation [ 5 – 7 ]. carcinoma cell epidermal growth factor (EGF) extracellular-signal-regulated kinase (ERK) Gab SHP2 small-interfering RNA (siRNA) The Biochemical Society, London 2005 4 2...
Articles
Joanne Darragh, Ana Soloaga, Victoria A. Beardmore, Andrew D. Wingate, Giselle R. Wiggin, Mark Peggie, J. Simon C. Arthur
Journal:
Biochemical Journal
Biochem J (2005) 390 (3): 749–759.
Published: 05 September 2005
... the equation: extracellular-signal-regulated kinase (ERK) mitogen- and stress-activated protein kinase (MSK) Nur77 Nurr1 Nor1 p38 MSK (mitogen- and stress-activated protein kinase)1 and MSK2 are dual kinase domain proteins that are activated by either the mitogenic stimulation...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 388 (3): 973–984.
Published: 07 June 2005
... connections in adult versus neonatal cells [ 6 ]. extracellular-signal-regulated kinase (ERK) hypertrophy Mnk mTOR myocyte protein synthesis Previous studies indicated the importance of Ras/Raf/MEK [where MEK stands for MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated...
Articles
Sandra MILASTA, Nicholas A. EVANS, Laura ORMISTON, Shelagh WILSON, Robert J. LEFKOWITZ, Graeme MILLIGAN
Journal:
Biochemical Journal
Biochem J (2005) 387 (3): 573–584.
Published: 26 April 2005
... this, there is currently little knowledge on the mechanisms of regulation of the orexin receptors. β-arrestin extracellular-signal-regulated kinase (ERK) G-protein-coupled receptor mitogen-activated protein kinase (MAPK) orexin receptor internalization Following co-expression in HEK-293T cells...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 387 (2): 315–324.
Published: 05 April 2005
... (email [email protected] ). 8 10 2004 8 11 2004 10 11 2004 10 11 2004 The Biochemical Society, London 2005 apoptosis death-effector domain extracellular-signal-regulated kinase (ERK) immunofluorescence ubiquitinylation Vanishin CHO cells were co...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 387 (2): 507–517.
Published: 05 April 2005
.... Sturgill T. W. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo J. Biol. Chem. 1999 274 2893 2898 21 Roux P. P. Richards S. A. Blenis J. Phosphorylation of p90 ribosomal S6...
Includes: Supplementary data
Articles
Matt MacCORMICK, Tanja MODERSCHEIM, Louise W. M. van der SALM, Anna MOORE, Shona Clements PRYOR, Gretchen McCAFFREY, Mark L. GRIMES
Journal:
Biochemical Journal
Biochem J (2005) 387 (1): 155–164.
Published: 22 March 2005
... with 20 units of CIP. extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase (MEK) nerve growth factor (NGF) PC12 cell Raf scaffold MAPK (mitogen-activated protein kinase) cascades must be controlled at many levels...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 385 (3): 695–702.
Published: 24 January 2005
... (email [email protected] ). 11 5 2004 4 10 2004 15 10 2004 15 10 2004 The Biochemical Society, London 2005 Drosophila melanogaster extracellular-signal-regulated kinase (ERK) initiation factor LK6 protein kinase translation factor The protein kinase...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 382 (2): 425–431.
Published: 24 August 2004
..., drained and then dissolved in SDS/PAGE sample buffer. For kinase or phosphatase assays, the final two washes were with 45 mM Tris/HCl, pH 7.4. AGC kinase extracellular-signal-regulated kinase (ERK) mitogen- and stress-activated kinase (MSK) protein phosphatase 2C (PP2C) p90 ribosomal S6 kinase...
Articles
Guadalupe SABIO, Suzana REUVER, Carmen FEIJOO, Masato HASEGAWA, Gareth M. THOMAS, Francisco CENTENO, Sven KUHLENDAHL, Sergio LEAL-ORTIZ, Michel GOEDERT, Craig GARNER, Ana CUENDA
Journal:
Biochemical Journal
Biochem J (2004) 380 (1): 19–30.
Published: 15 May 2004
... ). The Biochemical Society, London ©2004 2004 extracellular-signal-regulated kinase (ERK) phosphorylation stress stress-activated protein kinase-3 (SAPK3)/p38γ synapse synapse-associated protein 90 (SAP90)/postsynaptic density-95 (PSD-95) Abbreviations used: DIV, days in vitro ; DMEM, Dulbecco's...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 379 (3): 627–632.
Published: 01 May 2004
... 2004 3 2 2004 The Biochemical Society, London ©2004 2004 extracellular-signal-regulated kinase (ERK) G i GoLoco domain GTPase Rap regulator of G-protein signalling (RGS) Abbreviations used: AGS, activator of G-protein signalling; βARK, β-adrenergic receptor kinase; ERK...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 378 (2): 473–484.
Published: 01 March 2004
... GH4C1, MKP-1 gene transcription is strongly induced by thyrotropin-releasing hormone (TRH) as well as by epidermal growth factor (EGF) as a consequence of activated MAPK/extracellular-signal-regulated kinase (ERK) signalling. Intriguingly, reporter gene analysis with the MKP-1 promoter showed strong...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 373 (2): 613–620.
Published: 15 July 2003
... for TeTx on neurons is highly suspected [3]. Recently, growing evidence from our group suggests that TeTx can activate, through the HC fragment, intracellular signalling pathways, involving the Trk receptor, extracellular- signal-regulated kinase (ERK) and protein kinase C (PKC) iso- forms [4,5...
Articles
Xianjun FANG, Shuangxing YU, Ruth LAPUSHIN, Yiling LU, Tatsuro FURUI, Linda Z. PENN, David STOKOE, James R. ERICKSON, Robert C. BAST, JR, Gordon B. MILLS
Journal:
Biochemical Journal
Biochem J (2000) 352 (1): 135–143.
Published: 07 November 2000
...) of the MAPK family. Key words: cell survival, cell proliferation, extracellular-signal- regulated kinase (ERK), NIH 3T3 cells, phosphatidylinositol 3-kinase. phosphorylation of focal-adhesion proteins via a Rho-dependent pathway [15]. We have demonstrated previously that, compatible with its growth-factor...