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Keywords: fatty acid
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Articles

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

In Collection
Adipose biology
Alexander Yang, Emilio P. Mottillo
Journal: Biochemical Journal
Biochem J (2020) 477 (5): 985–1008.
https://doi.org/10.1042/BCJ20190468
Published: 13 March 2020
...Alexander Yang; Emilio P. Mottillo Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD) organelles by professional storage cells called adipocytes. These lipids are mobilized during adipocyte lipolysis, the fundamental process of hydrolyzing TAG to FAs...
View article titled, Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics
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Articles

Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20

Mohamed Rasheed Gadalla, Laurence Abrami, F. Gisou van der Goot, Michael Veit
Journal: Biochemical Journal
Biochem J (2020) 477 (1): 285–303.
https://doi.org/10.1042/BCJ20190752
Published: 17 January 2020
...Mohamed Rasheed Gadalla; Laurence Abrami; F. Gisou van der Goot; Michael Veit Hemagglutinin (HA), a glycoprotein of Influenza A viruses and its proton channel M2 are site-specifically modified with fatty acids. Whereas two cysteines in the short cytoplasmic tail of HA contain only palmitate...
View article titled, Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20
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Includes: Supplementary data
Articles

OleA Glu117 is key to condensation of two fatty-acyl coenzyme A substrates in long-chain olefin biosynthesis

Matthew R. Jensen, Brandon R. Goblirsch, James K. Christenson, Morgan A. Esler, Fatuma A. Mohamed, Lawrence P. Wackett, Carrie M. Wilmot
Journal: Biochemical Journal
Biochem J (2017) 474 (23): 3871–3886.
https://doi.org/10.1042/BCJ20170642
Published: 10 November 2017
... 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cerulenin crystallography fatty acid OleA thiolase The transition from reliance on fossil fuels to developing renewable hydrocarbons for biofuels and commodity chemicals has...
View article titled, OleA Glu117 is key to condensation of two fatty-acyl coenzyme A substrates in long-chain olefin biosynthesis
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Includes: Supplementary data
Articles

New route for the activation of poly(ADP-ribose) polymerase-1: a passage that links poly(ADP-ribose) polymerase-1 to lipotoxicity?

Péter Bai, Balázs Csóka
Journal: Biochemical Journal
Biochem J (2015) 469 (2): e9–e11.
https://doi.org/10.1042/BJ20150598
Published: 06 July 2015
... envisages a pathway through which ABCD3 translates enhanced fatty acid levels to ERK and consequently PARP-1 activation. The consequences of PARP-1 activation lead to cellular and tissue damage, implying that the ACBD3/PARP-1 pathway is an important pathway in lipotoxicity events. ACBD3 acyl-CoA...
View article titled, New route for the activation of poly(ADP-ribose) polymerase-1: a passage that links poly(ADP-ribose) polymerase-1 to lipotoxicity?
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Articles

Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans

Ida C. Elle, Karina T. Simonsen, Louise C. B. Olsen, Pernille K. Birck, Sidse Ehmsen, Simon Tuck, Thuc T. Le, Nils J. Færgeman
Journal: Biochemical Journal
Biochem J (2011) 437 (2): 231–241.
https://doi.org/10.1042/BJ20102099
Published: 28 June 2011
...-oxidation of unsaturated fatty acids. A quadruple mutant, lacking all basal ACBPs, is slightly developmentally delayed, displays abnormal intestinal lipid storage, and increased β-oxidation. Collectively, the present results suggest that each of the ACBP paralogues serves a distinct function in C. elegans...
View article titled, Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans
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Includes: Supplementary data
Articles

Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase

Xuefei Gao, Kuai Li, Xiaoyan Hui, Xiangping Kong, Gary Sweeney, Yu Wang, Aimin Xu, Maikun Teng, Pentao Liu, Donghai Wu
Journal: Biochemical Journal
Biochem J (2011) 435 (3): 723–732.
https://doi.org/10.1042/BJ20101680
Published: 13 April 2011
...Xuefei Gao; Kuai Li; Xiaoyan Hui; Xiangping Kong; Gary Sweeney; Yu Wang; Aimin Xu; Maikun Teng; Pentao Liu; Donghai Wu The adipocyte is the principal cell type for fat storage. CPT1 (carnitine palmitoyltransferase-1) is the rate-limiting enzyme for fatty acid β-oxidation, but the physiological role...
View article titled, Carnitine palmitoyltransferase 1A prevents <span class="search-highlight">fatty</span> <span class="search-highlight">acid</span>-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase
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Includes: Supplementary data
Articles

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Charlotte J. Green, Katherine Macrae, Sarah Fogarty, D. Grahame Hardie, Kei Sakamoto, Harinder S. Hundal
Journal: Biochemical Journal
Biochem J (2011) 435 (2): 463–474.
https://doi.org/10.1042/BJ20101517
Published: 29 March 2011
...Charlotte J. Green; Katherine Macrae; Sarah Fogarty; D. Grahame Hardie; Kei Sakamoto; Harinder S. Hundal Sustained over-supply of saturated non-esterified ‘free’ fatty acids has been shown to promote skeletal muscle insulin resistance, which may be driven, in part, by an increase in inflammatory...
View article titled, Counter-modulation of <span class="search-highlight">fatty</span> <span class="search-highlight">acid</span>-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase
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Includes: Supplementary data
Articles

Caenorhabditis elegans utilizes dauer pheromone biosynthesis to dispose of toxic peroxisomal fatty acids for cellular homoeostasis

Hyoe-Jin Joo, Yong-Hyeon Yim, Pan-Young Jeong, You-Xun Jin, Jeong-Eui Lee, Heekyeong Kim, Seul-Ki Jeong, David J. Chitwood, Young-Ki Paik
Journal: Biochemical Journal
Biochem J (2009) 422 (1): 61–71.
https://doi.org/10.1042/BJ20090513
Published: 29 July 2009
...Hyoe-Jin Joo; Yong-Hyeon Yim; Pan-Young Jeong; You-Xun Jin; Jeong-Eui Lee; Heekyeong Kim; Seul-Ki Jeong; David J. Chitwood; Young-Ki Paik Caenorhabditis elegans excretes a dauer pheromone or daumone composed of ascarylose and a fatty acid side chain, the perception of which enables worms to enter...
View article titled, Caenorhabditis elegans utilizes dauer pheromone biosynthesis to dispose of toxic peroxisomal <span class="search-highlight">fatty</span> <span class="search-highlight">acids</span> for cellular homoeostasis
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Includes: Supplementary data
Articles

Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs

Jie Wei, Hye Won Kang, David E. Cohen
Journal: Biochemical Journal
Biochem J (2009) 421 (2): 311–322.
https://doi.org/10.1042/BJ20090039
Published: 26 June 2009
... and interaction with StarD2 (also known as phosphatidylcholine-transfer protein, PC-TP), a regulator of fatty acid metabolism, we explored whether Them2 functions as a physiologically relevant fatty acyl-CoA thioesterase. In solution, Them2 formed a stable homotetramer, which denatured in a single transition...
View article titled, Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs
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Articles

Characterization of a phenylacetate–CoA ligase from Penicillium chrysogenum

Martijn J. Koetsier, Peter A. Jekel, Marco A. van den Berg, Roel A. L. Bovenberg, Dick B. Janssen
Journal: Biochemical Journal
Biochem J (2009) 417 (2): 467–476.
https://doi.org/10.1042/BJ20081257
Published: 23 December 2008
... for PAA and POA respectively. Surprisingly, PCL was very efficient in catalysing the conversion of trans -cinnamic acids to the corresponding CoA thioesters [ k cat / K m =(3.1±0.4)×10 2 mM −1 ·s −1 for trans -cinnamic acid]. Of all the substrates screened, medium-chain fatty acids, which also occur...
View article titled, Characterization of a phenylacetate–CoA ligase from Penicillium chrysogenum
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Articles

Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae

Søren Feddersen, Thomas B. F. Neergaard, Jens Knudsen, Nils J. Færgeman
Journal: Biochemical Journal
Biochem J (2007) 407 (2): 219–230.
https://doi.org/10.1042/BJ20070315
Published: 25 September 2007
.... Depletion of Acb1p resulted in the differential expression of genes encoding proteins involved in fatty acid and phospholipid synthesis (e.g. FAS1 , FAS2 , ACC1 , OLE1 , INO1 and OPI3 ), glycolysis and glycerol metabolism (e.g. GPD1 and TDH1 ), ion transport and uptake (e.g. ITR1 and HNM1 ) and stress...
View article titled, Transcriptional regulation of phospholipid biosynthesis is linked to <span class="search-highlight">fatty</span> <span class="search-highlight">acid</span> metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae
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Includes: Supplementary data
Articles

Metabolite transport across the peroxisomal membrane

Wouter F. Visser, Carlo W. T. van Roermund, Lodewijk Ijlst, Hans R. Waterham, Ronald J. A. Wanders
Journal: Biochemical Journal
Biochem J (2007) 401 (2): 365–375.
https://doi.org/10.1042/BJ20061352
Published: 21 December 2006
..., especially in higher eukaryotes. Peroxisomes catalyse a number of essential metabolic functions including fatty acid β-oxidation, ether phospholipid biosynthesis, fatty acid α-oxidation and glyoxylate detoxification. The involvement of peroxisomes in these metabolic pathways necessitates the transport...
View article titled, Metabolite transport across the peroxisomal membrane
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Articles

Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria

Telma C. Esteves, Nadeene Parker, Martin D. Brand
Journal: Biochemical Journal
Biochem J (2006) 395 (3): 619–628.
https://doi.org/10.1042/BJ20052004
Published: 11 April 2006
... from brown adipose tissue also showed synergistic activation of GDP-sensitive proton conductance by palmitate and 4-HNE. These results show that reactive alkenals activate the proton conductance of UCP1 more strongly when fatty acids are also added, with implications for both mechanistic...
View article titled, Synergy of <span class="search-highlight">fatty</span> <span class="search-highlight">acid</span> and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria
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Articles

Enhanced levels of Pis1p (phosphatidylinositol synthase) improve the growth of Saccharomyces cerevisiae cells deficient in Rsp5 ubiquitin ligase

Pawel Kaliszewski, Thierry Ferreira, Beata Gajewska, Anna Szkopinska, Thierry Berges, Teresa Żołądek
Journal: Biochemical Journal
Biochem J (2006) 395 (1): 173–181.
https://doi.org/10.1042/BJ20051726
Published: 15 March 2006
...Pawel Kaliszewski; Thierry Ferreira; Beata Gajewska; Anna Szkopinska; Thierry Berges; Teresa Żołądek The Rsp5 ubiquitin ligase plays a role in many cellular processes including the biosynthesis of unsaturated fatty acids. The PIS1 (phosphatidylinositol synthase gene) encoding the enzyme Pis1p which...
View article titled, Enhanced levels of Pis1p (phosphatidylinositol synthase) improve the growth of Saccharomyces cerevisiae cells deficient in Rsp5 ubiquitin ligase
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Articles

Computational evidence for protein-mediated fatty acid transport across the sarcolemma

Mark W. J. M. Musters, James B. Bassingthwaighte, Natal A. W. van Riel, Ger J. van der Vusse
Journal: Biochemical Journal
Biochem J (2006) 393 (3): 669–678.
https://doi.org/10.1042/BJ20050869
Published: 13 January 2006
...Mark W. J. M. Musters; James B. Bassingthwaighte; Natal A. W. van Riel; Ger J. van der Vusse Long-chain fatty acids (FAs) are important substrates used by the heart to fulfil its energy requirements. Prior to mitochondrial oxidation, blood-borne FAs must pass through the cell membrane...
View article titled, Computational evidence for protein-mediated <span class="search-highlight">fatty</span> <span class="search-highlight">acid</span> transport across the sarcolemma
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Articles

Conjugation of fatty acids with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide

Amir Malina, Yechiel Shai
Journal: Biochemical Journal
Biochem J (2005) 390 (3): 695–702.
https://doi.org/10.1042/BJ20050520
Published: 05 September 2005
... structure and amphipathicity. Previous studies have shown that the attachment of aliphatic acids to AMPs can increase [ 21 ] their antibacterial activity or endow them with antifungal activity [ 22 ]. It has also been shown recently that the attachment of a palmitoyl group, but not shorter fatty acids...
View article titled, Conjugation of <span class="search-highlight">fatty</span> <span class="search-highlight">acids</span> with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide
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Articles

Inhibitory effect of palmitate on the mitochondrial NADH:ubiquinone oxidoreductase (complex I) as related to the active–de-active enzyme transition

Maria V. LOSKOVICH, Vera G. GRIVENNIKOVA, Gary CECCHINI, Andrei D. VINOGRADOV
Journal: Biochemical Journal
Biochem J (2005) 387 (3): 677–683.
https://doi.org/10.1042/BJ20041703
Published: 26 April 2005
..., these results suggest that free fatty acids act as specific complex I-directed inhibitors; at a physiologically relevant temperature (37 °C), their inhibitory effects on mitochondrial NADH oxidation is due to perturbation of the pseudo-reversible active–de-active complex I transition. 7 10 2004 23 11...
View article titled, Inhibitory effect of palmitate on the mitochondrial NADH:ubiquinone oxidoreductase (complex I) as related to the active–de-active enzyme transition
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Articles

Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes

Roger SCHNEITER, Britta BRÜGGER, Clare M. AMANN, Glenn D. PRESTWICH, Raquel F. EPAND, Günther ZELLNIG, Felix T. WIELAND, Richard M. EPAND
Journal: Biochemical Journal
Biochem J (2004) 381 (3): 941–949.
https://doi.org/10.1042/BJ20040320
Published: 27 July 2004
...Roger SCHNEITER; Britta BRÜGGER; Clare M. AMANN; Glenn D. PRESTWICH; Raquel F. EPAND; Günther ZELLNIG; Felix T. WIELAND; Richard M. EPAND Morphological analysis of a conditional yeast mutant in acetyl-CoA carboxylase acc1 ts / mtr7 , the rate-limiting enzyme of fatty acid synthesis, suggested...
View article titled, Identification and biophysical characterization of a very-long-chain-<span class="search-highlight">fatty</span>-<span class="search-highlight">acid</span>-substituted phosphatidylinositol in yeast subcellular membranes
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Articles

Long-chain saturated fatty acids induce annexin II translocation to detergent-resistant membranes

Hong ZHAO, Robert W. HARDY
Journal: Biochemical Journal
Biochem J (2004) 381 (2): 463–469.
https://doi.org/10.1042/BJ20031083
Published: 06 July 2004
... by fatty acylation has been proposed to be an important protein-targeting mechanism for DRM association. However, little is known concerning the effects of LCSFA (long-chain saturated fatty acids) on protein composition of DRM in human cancer cells. In the present study, we found that, in Hs578T human...
View article titled, Long-chain saturated <span class="search-highlight">fatty</span> <span class="search-highlight">acids</span> induce annexin II translocation to detergent-resistant membranes
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Articles

Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D

Yong-Xin SUN, Kazuhito TSUBOI, Yasuo OKAMOTO, Takeharu TONAI, Makoto MURAKAMI, Ichiro KUDO, Natsuo UEDA
Journal: Biochemical Journal
Biochem J (2004) 380 (3): 749–756.
https://doi.org/10.1042/bj20040031
Published: 15 June 2004
... anandamide endocannabinoid fatty acid phospholipase D (PLD) Abbreviations used: LPA, lysophosphatidic acid; lysoPLD, lysophospholipase D; MAFP, methyl arachidonyl fluorophosphonate; NAE, N -acylethanolamine; PE, phosphatidylethanolamine; PL, phospholipase; cPLA 2 α, cytosolic PLA 2 α; sPLA 2...
View article titled, Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D
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Articles

A novel omega3-fatty acid desaturase involved in the biosynthesis of eicosapentaenoic acid

Suzette L. PEREIRA, Yung-Sheng HUANG, Emil G. BOBIK, Anthony J. KINNEY, Kevin L. STECCA, Jeremy C. L. PACKER, Pradip MUKERJI
Journal: Biochemical Journal
Biochem J (2004) 378 (2): 665–671.
https://doi.org/10.1042/bj20031319
Published: 01 March 2004
...Suzette L. PEREIRA; Yung-Sheng HUANG; Emil G. BOBIK; Anthony J. KINNEY; Kevin L. STECCA; Jeremy C. L. PACKER; Pradip MUKERJI Long-chain n −3 PUFAs (polyunsaturated fatty acids) such as EPA (eicosapentaenoic acid; 20:5 n −3) have important therapeutic and nutritional benefits in humans. In plants...
View article titled, A novel omega3-<span class="search-highlight">fatty</span> <span class="search-highlight">acid</span> desaturase involved in the biosynthesis of eicosapentaenoic acid
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Articles

Acylation of SC4 dodecapeptide increases bactericidal potency against Gram-positive bacteria, including drug-resistant strains

Nathan A. LOCKWOOD, Judith R. HASEMAN, Matthew V. TIRRELL, Kevin H. MAYO
Journal: Biochemical Journal
Biochem J (2004) 378 (1): 93–103.
https://doi.org/10.1042/bj20031393
Published: 15 February 2004
...Nathan A. LOCKWOOD; Judith R. HASEMAN; Matthew V. TIRRELL; Kevin H. MAYO We have conjugated dodecyl and octadecyl fatty acids to the N-terminus of SC4, a potently bactericidal, helix-forming peptide 12-mer (KLFKRHLKWKII), and examined the bactericidal activities of the resultant SC4 ‘peptide...
View article titled, Acylation of SC4 dodecapeptide increases bactericidal potency against Gram-positive bacteria, including drug-resistant strains
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Articles

Fatty acids enhance membrane permeabilization by pro-apoptotic Bax

Raquel F. EPAND, Jean-Claude MARTINOU, Sylvie MONTESSUIT, Richard M. EPAND
Journal: Biochemical Journal
Biochem J (2004) 377 (2): 509–516.
https://doi.org/10.1042/bj20030938
Published: 15 January 2004
...Raquel F. EPAND; Jean-Claude MARTINOU; Sylvie MONTESSUIT; Richard M. EPAND Fatty acids are known promoters of apoptosis. In the present study, the direct role of fatty acids with regard to their ability to cause membrane permeabilization by Bax was explored. Addition of fatty acids to liposomes...
View article titled, <span class="search-highlight">Fatty</span> <span class="search-highlight">acids</span> enhance membrane permeabilization by pro-apoptotic Bax
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Articles

Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds

Martin D. BRAND, Nigel TURNER, Augustine OCLOO, Paul L. ELSE, A. J. HULBERT
Journal: Biochemical Journal
Biochem J (2003) 376 (3): 741–748.
https://doi.org/10.1042/bj20030984
Published: 15 December 2003
... positively and monounsaturation correlated negatively with proton conductance. These correlations echo those seen in mammalian liver mitochondria, suggesting that they too are general for endotherms. Key words: allometry, body mass, fatty acid, mitochondria, phospholipid, proton conductance. INTRODUCTION...
View article titled, Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds
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Articles

Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi

Marisa J. WAINSZELBAUM, María L. BELAUNZARÁN, Estela M. LAMMEL, Mónica FLORIN-CHRISTENSEN, Jorge FLORIN-CHRISTENSEN, Elvira L. D. ISOLA
Journal: Biochemical Journal
Biochem J (2003) 375 (3): 705–712.
https://doi.org/10.1042/bj20021907
Published: 01 November 2003
... that reside with the free-fatty-acid fraction, especially oleic acid. These compounds stimulate de novo diacylglycerol formation and protein kinase C activity in the parasite. Moreover, metacyclogenesis is stimulated by phorbol esters and cell-permeant diacylglycerol, while protein kinase C down-regulation...
View article titled, Free <span class="search-highlight">fatty</span> <span class="search-highlight">acids</span> induce cell differentiation to infective forms in Trypanosoma cruzi
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Articles

Control of human carnitine palmitoyltransferase II gene transcription by peroxisome proliferator-activated receptor through a partially conserved peroxisome proliferator-responsive element

María J. BARRERO, Nuria CAMARERO, Pedro F. MARRERO, Diego HARO
Journal: Biochemical Journal
Biochem J (2003) 369 (3): 721–729.
https://doi.org/10.1042/bj20020851
Published: 01 February 2003
...María J. BARRERO; Nuria CAMARERO; Pedro F. MARRERO; Diego HARO The expression of several genes involved in fatty acid metabolism is regulated by peroxisome proliferator-activated receptors (PPARs). To gain more insight into the control of carnitine palmitoyltransferase (CPT) gene expression, we...
View article titled, Control of human carnitine palmitoyltransferase II gene transcription by peroxisome proliferator-activated receptor through a partially conserved peroxisome proliferator-responsive element
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Articles

Evaluation of the role of peroxisome-proliferator-activated receptor α in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism

Mark J. HOLNESS, Nicholas D. SMITH, Karen BULMER, Teresa HOPKINS, Geoffrey F. GIBBONS, Mary C. SUGDEN
Journal: Biochemical Journal
Biochem J (2002) 364 (3): 687–694.
https://doi.org/10.1042/bj20011841
Published: 15 June 2002
... protein expression to hyperthyroidism in either the fed or starved state. Our data support the hypothesis that cardiac PDK4 protein expression is regulated, at least in part, by a fatty acid-dependent, PPARα-independent mechanism and strongly implicate a fall in insulin in either initiating...
View article titled, Evaluation of the role of peroxisome-proliferator-activated receptor α in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism
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Articles

Mycolic acid biosynthesis and enzymic characterization of the β-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis

Laurent KREMER, Lynn G. DOVER, Séverine CARRÈRE, K. Madhavan NAMPOOTHIRI, Sarah LESJEAN, Alistair K. BROWN, Patrick J. BRENNAN, David E. MINNIKIN, Camille LOCHT, Gurdyal S. BESRA
Journal: Biochemical Journal
Biochem J (2002) 364 (2): 423–430.
https://doi.org/10.1042/bj20011628
Published: 01 June 2002
...Laurent KREMER; Lynn G. DOVER; Séverine CARRÈRE; K. Madhavan NAMPOOTHIRI; Sarah LESJEAN; Alistair K. BROWN; Patrick J. BRENNAN; David E. MINNIKIN; Camille LOCHT; Gurdyal S. BESRA Mycolic acids consist of long-chain α-alkyl-β-hydroxy fatty acids that are produced by successive rounds of elongation...
View article titled, Mycolic acid biosynthesis and enzymic characterization of the β-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis
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Articles

Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor

Alexandre K. ROUQUETTE-JAZDANIAN, Claudette PELASSY, Jean-Philippe BREITTMAYER, Jean-Louis COUSIN, Claude AUSSEL
Journal: Biochemical Journal
Biochem J (2002) 363 (3): 645–655.
https://doi.org/10.1042/bj3630645
Published: 24 April 2002
... activation. Our method is based on metabolic labelling of Jurkat T-cells with different precursors of glycerophospholipid synthesis, including glycerol and fatty acids with different lengths and degrees of saturation as well as phospholipid polar head groups. The results obtained indicate that lipid rafts...
View article titled, Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor
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Articles

Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization

Jan-Willem H. P. VAN DE LOO, Meike TEUCHERT, Ilse PAULI, Evelyn PLETS, Wim J. M.VAN DE VEN, John W. M. CREEMERS
Journal: Biochemical Journal
Biochem J (2000) 352 (3): 827–833.
https://doi.org/10.1042/bj3520827
Published: 08 December 2000
..., but does not function as a dominant trafficking signal. Key words: fatty acid, post-translational modification, stability. embryogenesis and adult life [17 19a]. Substrate specificity is similar to, but not identicalwith, other PCs [11,20]. LPC is a type-I transmembrane protein that localizes...
View article titled, Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization
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Articles

Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity

J. Denis MCGARRY, Nicholas F. BROWN
Journal: Biochemical Journal
Biochem J (2000) 349 (1): 179–187.
https://doi.org/10.1042/bj3490179
Published: 26 June 2000
...J. Denis MCGARRY; Nicholas F. BROWN Carnitine palmitoyltransferase I (CPT I) catalyses the initial step of fatty acid import into the mitochondrial matrix, the site of β-oxidation, and its inhibition by malonyl-CoA is a primary control point for this process. The enzyme exists in at least two...
View article titled, Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity
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Articles

Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors

Kiran T. MALHOTRA, Khushbeer MALHOTRA, Bertram H. LUBIN, Frans A. KUYPERS
Journal: Biochemical Journal
Biochem J (1999) 344 (1): 135–143.
https://doi.org/10.1042/bj3440135
Published: 08 November 1999
..., spleen and skeletal muscle. The 78 kDa expressed LACS5 protein used the long-chain fatty acids palmitic acid, oleic acid and arachidonic acid as substrates. Antibodies directed against LACS5 cross-reacted with erythrocyte membranes. We conclude that early erythrocyte precursors express at least two...
View article titled, Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors
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Articles

Production in vitro by the cytochrome P450 CYP94A1 of major C 18 cutin monomers and potential messengers in plant–pathogen interactions: enantioselectivity studies

Franck PINOT, Irène BENVENISTE, Jean-Pierre SALAüN, Olivier LOREAU, Jean-Pierre NOËL, Lukas SCHREIBER, Francis DURST
Journal: Biochemical Journal
Biochem J (1999) 342 (1): 27–32.
https://doi.org/10.1042/bj3420027
Published: 10 August 1999
... Society, London © 1999 1999 chirality epoxide fatty acid ω-hydroxylase Biochem. J. (1999) 342, 27 32 (Printed in Great Britain) 27 Production in vitro by the cytochrome P450 CYP94A1 of major C18 cutin monomers and potential messengers in plant pathogen interactions : enantioselectivity studies...
View article titled, Production in vitro by the cytochrome P450 CYP94A1 of major C 18 cutin monomers and potential messengers in plant–pathogen interactions: enantioselectivity studies
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