... aging cardiac function fatty acid oxidation lysine acetylation mitochondria Cardiovascular disease (CVD) is the leading cause of death globally, and aging has presented as a significant CVD risk factor [ 1 , 2 ]. By the year 2030, ∼20% of the world's population will reach the age of 65...

... ) 24 4 2019 20 6 2019 24 6 2019 24 6 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 electron microscopy enzymology fatty acid oxidation lipid metabolism small angle scattering trifunctional enzyme Fatty...

... demand, result in a feedback allosteric inhibition of fatty acid oxidation, carbohydrate oxidation and ketone oxidation. The main site of inhibition of fatty acid β-oxidation is at the level of 3-ketoacyl-CoA thiolase [ 9 ], while the main site of inhibition of carbohydrate oxidation is at the level...

...Iman Momken; Adrian Chabowski; Ellen Dirkx; Miranda Nabben; Swati S. Jain; Jay T. McFarlan; Jan F.C. Glatz; Joost J.F.P. Luiken; Arend Bonen Leptin stimulates fatty acid oxidation in muscle and heart; but, the mechanism by which these tissues provide additional intracellular fatty acids...

... by a reduction in arginase expression and up-regulation of pro-inflammatory cytokines [ 1 ]. apoA-I mimetic peptide fatty acid oxidation macrophage polarization mitochondrial respiration oxygen consumption rate PPARγ 4F-mediated differentiation of monocyte-derived macrophages to an anti...

... levels were reduced by ~50% after starvation, ex229-induced AMPK activation and glucose uptake were amplified in a wortmannin-independent manner. In L6 myotubes incubated with ex229, fatty acid oxidation was increased. Furthermore, in mouse EDL (extensor digitorum longus) and soleus muscles, ex229...

.... The significance of Nrf2 in intermediary metabolism is also beginning to be recognized. Thus this transcription factor negatively affects fatty acid synthesis. However, the effect of Nrf2 on fatty acid oxidation is currently unknown. In the present paper, we report that the mitochondrial oxidation of long-chain...

... compilation © 2009 Biochemical Society 2009 carnitine palmitoyltransferase 1 fatty acid oxidation lipogenesis liver mitochondrion triacylglycerol During the last 24 h of culture, the medium was replaced by a medium containing either 5 mM glucose or 20 mM glucose plus 10 nM insulin...

..., consistent with lower rates of fatty acid oxidation due to increased rates of glucose and pyruvate oxidation due to greater PDC activity. Up-regulation of PDHK4 in tissues other than the liver is clearly important during starvation for regulation of PDC activity and glucose homoeostasis. 1 Present...

... heterogeneous, and (iv) the labelling of C1+2 of β-hydroxybutyrate does not reflect the labelling of acetyl-CoA used in the citric acid cycle. The Biochemical Society, London 2005 acetylcarnitine acetyl-CoA fatty acid oxidation β-hydroxybutyrate malonyl-CoA metabolic channelling peroxisome...

... liver isoform of CPT I. The overexpression of CPT I in INS1E cells caused a more than a 5-fold increase in the levels of CPT I protein (detected by Western blotting), a 6-fold increase in the CPT activity, and an increase in fatty acid oxidation at 2.5mM glucose (1.7-fold) and 15mM glucose (3.1-fold...

... Databases under the accession number AF338424. 21 2 2001 2 4 2001 25 4 2001 The Biochemical Society, London ©2001 2001 fatty acid oxidation peroxisomes pyrophosphatase Abbreviations used: DsRed, Discosoma red fluorescent protein; EST, expressed sequence tag; GFP...

... or pathological states. The purpose of the present study was to investigate the role of liver MCD in the regulation of fatty acid oxidation in situations where lipid metabolism is altered. A single MCD enzyme of molecular mass 50.7kDa was purified from rat liver using a sequential column chromatography procedure...

... 1999 24 3 1999 The Biochemical Society, London © 1999 1999 fatty acid oxidation M13 phage peroxisomal metabolism Biochem. J. (1999) 340, 561 568 (Printed in Great Britain) 561 Identification of peroxisomal proteins by using M13 phage protein VI phage display : molecular evidence...

.... The distribution of the enzyme shows a broad range of activities from very low in the brain to elevated in the liver and heart. The results provide the foundations for further studies of the role of MCD in lipid metabolism and metabolic signalling in various tissues. Key words: fatty acid oxidation, insulin...