.... Prior research that revealed a structurally atypical ligand-binding domain (LBD) and failed to locate an endogenous ligand had led to a classification of Nur77 as an orphan receptor. However, several more recent studies indicate that small synthetic molecules and unsaturated fatty acids can bind...

... docking. The results demonstrate the ability of CYP267B1 to perform in-chain hydroxylations of medium-chain saturated fatty acids (decanoic acid, dodecanoic acid and tetradecanoic acid) and a regioselective hydroxylation of flavanone. The fatty acids are mono-hydroxylated at different in-chain positions...

...Edgars Liepinsh; Marina Makrecka-Kuka; Kristine Volska; Janis Kuka; Elina Makarova; Unigunde Antone; Eduards Sevostjanovs; Reinis Vilskersts; Arnis Strods; Kaspars Tars; Maija Dambrova The accumulation of long-chain fatty acids (FAs) and their CoA and carnitine esters is observed in the ischaemic...

... ligand remains unknown, ZAG binds the dansylated C 11 fatty acid 11-(dansylamino)undecanoic acid (DAUDA) in the groove between the α1 and α2 domains. The surface of ZAG has approximately 15 weak zinc-binding sites deemed responsible for precipitation from human plasma. In the present study the functional...

... charge of the cell. A hallmark of many cancers is high rates of fatty acid synthesis and AMPK inhibits this pathway through phosphorylation of acetyl-CoA carboxylase (ACC). It is currently unknown whether targeting the AMPK–ACC-lipogenic pathway using salicylate and/or metformin may be effective...

...Suresh Chintalapati; Jogadhenu Shyam Sunder Prakash; Pratima Gupta; Shuji Ohtani; Iwane Suzuki; Toshio Sakamoto; Norio Murata; Sisinthy Shivaji Acyl-lipid desaturases are enzymes that convert a C–C single bond into a C=C double bond in fatty acids that are esterified to membrane-bound glycerolipids...

...Shubha MURTHY; Ella BORN; Satya N. MATHUR; F. Jeffrey FIELD The effect of fatty acids on LXR (liver X receptors)-mediated enhancement of ABCA1 (ATP-binding cassette transporter A1) expression and cholesterol efflux was investigated in human intestinal cells CaCo-2. LXR activation by T0901317...

... at the transcriptional level, or via the synthesis of lipid activators or substrates of the CDP-choline pathway. To assess the contributions of these two mechanisms, we examined CCTα expression and PtdCho synthesis by the CDP-choline pathway in cholesterol and fatty acid auxotrophic CHO M19 cells inducibly expressing...

...Carine DUVAL; Nathalie AUGÉ; Marie-Françoise FRISACH; Louis CASTEILLA; Robert SALVAYRE; Anne NÈGRE-SALVAYRE Mitochondria generate reactive oxygen species (ROS) under various pathophysiological conditions. In isolated mitochondria, fatty acids (FA) exhibit an uncoupling effect of the respiratory...

... utilization is com- pensated by increased supply and utilization of available lipid- derived substrates [non-esterified fatty acids (NEFA), triglyceride (TAG) and ketone bodies]. These observations support the concept that substrate competition, with preferential oxidation of lipid rather than glucose...

..., reverse transcriptase PCR; QEA, Quantitative Expression Analysis; ORF, open reading frame; NEFA, non-esterified fatty acid. fatty acids hydrolase metabolic rate 1 To whom correspondence should be addressed, at Metabolic and Cardiovascular Disease Pharmacology Department, Novartis...

... substrates, such as fatty acids or ketone bodies. Furthermore, muscle is the main reservoir of amino acids and protein. The activity of many different plasma membrane transporters, such as glucose carriers and transporters of carnitine, creatine and amino acids, play a crucial role in muscle metabolism...

..., Bethesda, MD 20814-9692, U.S.A. 17 12 1998 4 8 1999 7 9 1999 The Biochemical Society, London © 1999 1999 atherosclerosis cholesterol fatty acids inflammation phospholipids Biochem. J. (1999) 344, 7 13 (Printed in Great Britain) 7 Apolipoprotein serum amyloid A down...

... fatty acids liver secretion Biochem. J. (1999) 343, 505 515 (Printed in Great Britain) 505 REVIEW ARTICLE The malonyl-CoA long-chain acyl-CoA axis in the maintenance of mammalian cell function Victor A. ZAMMIT1 Cell Biochemistry, Hannah Research Institute, Ayr, KA6 5HL, Scotland, U.K. Long-chain...

... cell-free system showed that the pathway begins as in other eukaryotes, with the addition of N -acetylglucosamine to phosphatidylinositol, followed by deacetylation of the sugar residue. The third step, acylation of the inositol ring, seemed to involve a fatty acid other than palmitate, in contrast...

... synthase gene expression remain to be fully characterized, but probably involve changes in circulating hormones and fatty acids. The rat mitochondrial HMG-CoA synthase gene contains elements that mediate its multihormonal regulation and tissue specificity [12]. Recently, it has been shown...