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Keywords: feedback inhibition
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Articles

Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans

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Peng Zhang, Jun Ma, Zilong Zhang, Manwu Zha, Hai Xu, Guoping Zhao, Jianping Ding
Journal: Biochemical Journal
Biochem J (2009) 421 (1): 133–143.
https://doi.org/10.1042/BJ20090336
Published: 12 June 2009
... feedback inhibition by its end product isoleucine. To understand the molecular basis of the high selectivity of the inhibitor and the mechanism of feedback inhibition, we determined the crystal structure of Li CMSC (C-terminal regulatory domain of Li CMS) in complex with isoleucine, and performed...
View article titled, Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans
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Includes: Supplementary data
Articles

Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans

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Jun Ma, Peng Zhang, Zilong Zhang, Manwu Zha, Hai Xu, Guoping Zhao, Jianping Ding
Journal: Biochemical Journal
Biochem J (2008) 415 (1): 45–56.
https://doi.org/10.1042/BJ20080242
Published: 12 September 2008
... conditions. All kinetic data were analysed using Prism 4.0 for Windows (GraphPad) and the kinetic parameters ( V max , K m and k cat ) were calculated from the Scatchard plots. aldol condensation catalytic mechanism citramalate synthase crystal structure feedback inhibition substrate...
View article titled, Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
Open the PDF for Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans in another window
Includes: Supplementary data