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Keywords: ferritin
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Articles
Biochem J (2019) 476 (6): 975–989.
Published: 22 March 2019
...Didi He; Cecilia Piergentili; Jennifer Ross; Emma Tarrant; Laura R. Tuck; C. Logan Mackay; Zak McIver; Kevin J. Waldron; David J. Clarke; Jon Marles-Wright Ferritins are a large family of intracellular proteins that protect the cell from oxidative stress by catalytically converting Fe(II) into less...
Includes: Supplementary data
Articles
Biochem J (2015) 472 (1): 1–15.
Published: 30 October 2015
...Paolo Arosio; Fernando Carmona; Raffaella Gozzelino; Federica Maccarinelli; Maura Poli Ferritins, the main intracellular iron storage proteins, have been studied for over 60 years, mainly focusing on the mammalian ones. This allowed the elucidation of the structure of these proteins and the...
Articles
Biochem J (2013) 449 (1): 189–194.
Published: 07 December 2012
... intracellular iron which usually tends to amplify oxidant killing. However, HO-1-overexpressing cells contain only ~25% as much ‘loose’ (probably redox active) iron. Indeed, inhibition of ferritin synthesis [via siRNA (small interfering RNA) directed at the ferritin heavy chain] sensitizes the HO-1...
Includes: Supplementary data
Articles
Biochem J (2011) 434 (3): 365–381.
Published: 24 February 2011
... or iron–sulfur clusters, which are integral parts of several metalloproteins, and excess iron is stored and detoxified in cytosolic ferritin. Iron metabolism is controlled at different levels and by diverse mechanisms. The present review summarizes basic concepts of iron transport, use and storage...
Articles
Biochem J (2010) 429 (3): 463–471.
Published: 14 July 2010
...Marc Mikhael; Alex D. Sheftel; Prem Ponka Iron is essential for all life, yet can be dangerous under certain conditions. Iron storage by the 24-subunit protein ferritin renders excess amounts of the metal non-reactive and, consequentially, ferritin is crucial for life. Although the mechanism...
Articles
Biochem J (2008) 411 (1): 107–113.
Published: 13 March 2008
...-cells), resulting in the transcriptional activation of target genes such as IL-2 (interleukin-2). In the present study, we found that increased intracellular calcium leads to induction of the antioxidant protein ferritin H. We previously reported that the ferritin H gene is transcriptionally activated...
Articles
Biochem J (2007) 405 (3): 523–531.
Published: 13 July 2007
... in the three genes. The aco1 - 1 and aco3 - 1 mutants show a clear decrease in cytosolic ACO activity. However, none of the mutants is affected in respect of the accumulation of the ferritin transcript or protein in response to iron excess. cis -acting elements potentially able to bind to the IRP...
Articles
Biochem J (2006) 397 (1): 61–67.
Published: 14 June 2006
... metal transporter 1), IREG1 (iron-regulated protein 1) and ferritin in duodenum. Liver and spleen samples were used to determine hepcidin mRNA expression. Changes in serum iron and iron loading of duodenum, spleen and liver were also determined. We found a significant ( P <0.05) fall in serum iron 3...
Articles
Biochem J (2005) 388 (1): 143–150.
Published: 10 May 2005
... aconitase ferritin iron metabolism iron regulatory protein iron-responsive element transferrin receptor Iron is essential for a number of cellular functions, but when present in excess, it catalyses the generation of reactive oxygen species, and leads to tissue damage [ 1 ]. Consequently, iron...
Articles
Biochem J (2003) 370 (3): 891–899.
Published: 15 March 2003
..., manifested in the activation of iron-regulatory protein and concomitant increase in transferrin receptor levels and decrease in ferritin content. This phenotype persists in cells expressing wild-type HFE after transfection with a β 2 M cDNA. Whereas endogenous β 2 M is sufficient for the presentation of at...
Articles
Biochem J (2002) 365 (1): 127–132.
Published: 01 July 2002
... mice, following phagocytosis of 59 Fe-labelled transferrin—anti-transferrin immune complexes, showed reduced iron release compared with cells from wild-type iNOS littermates. Uptake of the complexes by macrophages was similar in iNOS-deficient and wild-type mice. Ferritin was up-regulated by IFNγ/LPS...
Articles
Biochem J (1999) 341 (1): 173–178.
Published: 24 June 1999
... measurements have been obtained between AFM probes functionalized with the β-subunit of human chorionic gonadotrophin (βhCG) and surfaces functionalized with anti-βhCG antibody. A comparison of the obtained results with previous anti-ferritin antibody-binding data identifies differences when the antigen...