... could interact with PCBP2 in vitro , whereas iron-chelated DMT1 could not. These results indicate that ferrous iron imported by DMT1 is transferred directly to PCBP2. Moreover, we demonstrated that PCBP2 could bind to ferroportin, which exports ferrous iron out of the cell. These findings suggest...

...Rafał R. Starzyński; François Canonne-Hergaux; Małgorzata Lenartowicz; Wojciech Krzeptowski; Alexandra Willemetz; Agnieszka Styś; Joanna Bierła; Piotr Pietrzak; Tomasz Dziaman; Paweł Lipiński HO1 (haem oxygenase 1) and Fpn (ferroportin) are key proteins for iron recycling from senescent red blood...

... the solute carrier and Fe 2+ transporter ferroportin (also known as SLC11A3). The ferroportin-mediated efflux of Fe 2+ is coupled by its re-oxidation to Fe 3+ , catalysed by the membrane-bound ferroxidase hephaestin that physically interacts with ferroportin [ 10 ], and possibly also by its plasma...

..., by interacting with the iron transporter ferroportin, prevents further iron import into the circulatory system. This conclusion was reached using the corresponding synthetic peptide, emphasizing the functional importance of the mature 25-mer peptide, but omitting the possible functionality of its maturation...

...Jaya P. Gnana-Prakasam; Pamela M. Martin; Barbara A. Mysona; Penny Roon; Sylvia B. Smith; Vadivel Ganapathy Hepcidin is a hormone central to the regulation of iron homeostasis in the body. It is believed to be produced exclusively by the liver. Ferroportin, an iron exporter, is the receptor...

... the iron exporter Fpn (ferroportin). We previously described a cellular model of EP (erythrophagocytosis), based on primary cultures of mouse BMDMs (bone-marrow-derived macrophages) and aged murine RBCs, and showed that EP induces changes in the expression profiles of Fpn and HO1. In the present paper, we...

...Ana Sofia Gonçalves; Françoise Muzeau; Rand Blaybel; Gilles Hetet; Fathi Driss; Constance Delaby; François Canonne-Hergaux; Carole Beaumont Ferroportin [FPN; Slc40a1 (solute carrier family 40, member 1)] is a transmembrane iron export protein expressed in macrophages and duodenal enterocytes...