... and RhoA, which are prominent upstream regulators of the actin cytoskeleton. The present review concerns a class of Rho GAPs, FilGAP ( ARHGAP24 gene product) and its close relatives ( ARHGAP22 and AHRGAP25 gene products). FilGAP is a GAP for Rac1 and a binding partner of FLNa (filamin A), a widely...

...Salla Ruskamo; Robert Gilbert; Gregor Hofmann; Pengju Jiang; Iain D. Campbell; Jari Ylänne; Ulla Pentikäinen Filamins are large proteins that cross-link actin filaments and connect to other cellular components. The C-terminal rod 2 region of FLNa (filamin A) mediates dimerization and interacts...

...-phosphorylation of JNK by MKK4 precedes threonine-phosphorylation by MKK7, and that both are required for synergistic JNK activation. In the present study, we identify the actin-binding protein-280 (Filamin A) as a presumed ‘binder’ protein that can bind to MKK7, as well as to MKK4, connecting them in close...

... protein FLNc (filamin C). PKBα phosphorylated FLNc at Ser 2213 in vitro , which lies in an insert not present in the FLNa and FLNb isoforms. Ser 2213 became phosphorylated when C2C12 myoblasts were stimulated with insulin or epidermal growth factor, and phosphorylation was prevented by low concentrations...