Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Date
Availability
1-16 of 16
Keywords: focal adhesion
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Articles
Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyte
Open Access
Journal:
Biochemical Journal
Biochem J (2025) 482 (11): 763–788.
Published: 02 June 2025
..., including calcium regulation, cell survival, cell polarity, phase separation-mediated actin reorganization, and SD–focal adhesion dynamics. Collectively, our emerging understanding of the broader cellular context of nephrin signaling provides important insight for clinical strategies to mitigate podocyte...
Articles
Slc25a36 modulates pluripotency of mouse embryonic stem cells by regulating mitochondrial function and glutathione level
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2019) 476 (11): 1585–1604.
Published: 11 June 2019
... potential, and low numbers. The key transcription regulators of mitochondrial biogenesis also decreased. These results indicate that mitochondrial dysfunction leads to an inability to support the pluripotency maintenance. Moreover, down-regulated glutathione metabolism and up-regulated focal adhesion...
Includes: Supplementary data
Articles
Secretagogin affects insulin secretion in pancreatic β-cells by regulating actin dynamics and focal adhesion
Open AccessSeo-Yun Yang, Jae-Jin Lee, Jin-Hee Lee, Kyungeun Lee, Seung Hoon Oh, Yu-Mi Lim, Myung-Shik Lee, Kong-Joo Lee
Journal:
Biochemical Journal
Biochem J (2016) 473 (12): 1791–1803.
Published: 10 June 2016
... adhesion, a critical step in the second phase of insulin secretion, we examined the effect of silencing SCGN on focal adhesion molecules, including FAK (focal adhesion kinase) and paxillin, and the cell survival molecules ERK1/2 (extracellular-signal-regulated kinase 1/2) and Akt. We found that glucose...
Includes: Supplementary data
Articles
Vinculin-dependent actin bundling regulates cell migration and traction forces
Available to PurchaseKarry M. Jannie, Shawn M. Ellerbroek, Dennis W. Zhou, Sophia Chen, David J. Crompton, Andrés J. García, Kris A. DeMali
Journal:
Biochemical Journal
Biochem J (2015) 465 (3): 383–393.
Published: 22 January 2015
.... Cells expressing a mutant vinculin deficient in actin binding and bundling display migration and traction force defects. Vinculin binding to actin is critical for cell migration and force generation. actin adhesion focal adhesion force vinculin Cell migration is a complex process...
Articles
MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells
Available to PurchaseMagdalene Ameka, Michael P. Kahle, Mathew Perez-Neut, Saverio Gentile, Ahmed A. Mirza, Bruce D. Cuevas
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 99–108.
Published: 23 October 2014
... cell attachment to fibronectin recruits MEKK2 to focal adhesion complexes, and that MEKK2 knockdown is associated with stabilized focal adhesions and significant inhibition of tumour cell migration. In the present study we investigate MEKK2 function in focal adhesions and we report that MEKK2...
Includes: Supplementary data
Articles
Adenylate cyclase-centred microdomains
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2014) 462 (2): 199–213.
Published: 07 August 2014
... as part of a regulated, but continuous, process. A more dynamic situation may occur at FAs (focal adhesions), where a scaffolding AC could play a key regulatory and dynamic structural role. FAs are large macromolecular assemblies through which both mechanical force and regulatory signals are transmitted...
Articles
c-Src-induced activation of ceramide metabolism impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions
Available to PurchaseKentaro Kajiwara, Takayuki Yamada, Takeshi Bamba, Eiichiro Fukusaki, Fumio Imamoto, Masato Okada, Chitose Oneyama
Journal:
Biochemical Journal
Biochem J (2014) 458 (1): 81–93.
Published: 20 January 2014
...Kentaro Kajiwara; Takayuki Yamada; Takeshi Bamba; Eiichiro Fukusaki; Fumio Imamoto; Masato Okada; Chitose Oneyama The proto-oncogenic tyrosine kinase c-Src is up-regulated in various human cancers, implicating its role in tumour progression. Upon activation, c-Src translocates to focal adhesions...
Includes: Supplementary data
Articles
SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2013) 454 (1): 13–30.
Published: 26 July 2013
... as with focal adhesions and cell junctions, and are probably involved in cell migration, polarity and proliferation. Finally, we consider the association of GCKIIIs with a number of human diseases, particularly cerebral cavernous malformations. 1 Correspondence may be addressed to either of these authors...
Includes: Multimedia, Supplementary data
Articles
mRNA encoding WAVE–Arp2/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2013) 452 (1): 45–55.
Published: 25 April 2013
..., although it is unclear as to the nature of the protrusions, or whether they involved active protein synthesis [ 18 ]. © The Authors Journal compilation © 2013 Biochemical Society 2013 cell division cycle 42 (Cdc42) focal adhesion mRNA Rac1 RhoA translation SV40 (simian virus 40...
Includes: Supplementary data
Articles
Modulation of mammary cancer cell migration by 15-deoxy-Δ 12,14 -prostaglandin J 2 : implications for anti-metastatic therapy
Available to PurchaseAnne R. Diers, Brian P. Dranka, Karina C. Ricart, Joo Yeun Oh, Michelle S. Johnson, Fen Zhou, Manuel A. Pallero, Thomas M. Bodenstine, Joanne E. Murphy-Ullrich, Danny R. Welch, Aimee Landar
Journal:
Biochemical Journal
Biochem J (2010) 430 (1): 69–78.
Published: 28 July 2010
... investigate the effect of the electrophilic prostaglandin 15d-PGJ 2 (15-deoxy-Δ 12,14 -prostaglandin J 2 ) on metastatic properties of breast cancer cells. 15d-PGJ 2 was shown to decrease migration, stimulate focal-adhesion disassembly and cause extensive F-actin (filamentous actin) reorganization at low...
Includes: Supplementary data
Articles
Human α-synemin interacts directly with vinculin and metavinculin
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 409 (3): 657–667.
Published: 15 January 2008
... with vinculin in vivo , and this association is promoted by PtdIns(4,5) P 2 . SNTIII also specifically co-localizes with vinculin within focal adhesions when transiently expressed in mammalian cells. In contrast, other regions of synemin show distinct localization patterns in comparison with those of SNTIII...
Articles
An alternatively spliced exon links intermediate filaments to adhesions
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 409 (3): e1–e2.
Published: 15 January 2008
... of the type IV intermediate filament protein synemin interacts directly with the focal adhesion protein vinculin in its active state. Interaction of adhesion components with intermediate filaments could serve as a general mechanism to regulate cell- and tissue-specific cytoskeleton-membrane attachment...
Articles
αII-Spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contacts
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 388 (2): 631–638.
Published: 24 May 2005
...: the potential tumour suppressor Tes, an actin-binding protein mainly located at focal adhesions; and EVL (Ena/vasodilator-stimulated phosphoprotein-like protein), another actin-binding protein, equally recruited at focal adhesions. Interactions between spectrin and overexpressed Tes and EVL were confirmed by co...
Articles
Phosphoinositides differentially regulate alpha-actinin flexibility and function
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 378 (3): 1067–1072.
Published: 15 March 2004
... 12 12 2003 The Biochemical Society, London ©2004 2004 α-actinin actin bundling cytoskeleton focal adhesion phosphoinositide protein flexibility Abbreviations used: CH, calponin homology; GST, glutathione S-transferase. Biochem. J. (2004) 378, 1067 1072 (Printed in Great...
Articles
A role of tensin in skeletal-muscle regeneration
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 356 (3): 737–745.
Published: 08 June 2001
... myogenic cells identified by bromodeoxyuridine and desmin double labelling in knockout mice on the first 2 days after injury. Expression of INTRODUCTION Focal adhesions are specialized cell-substratum junctions that are present in cells attaching to extracellular matrix. They are formed around...
Articles
Molecular characterization of human tensin
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 351 (2): 403–411.
Published: 10 October 2000
...Huaiyang CHEN; Akiko ISHII; Wai-Keung WONG; Lan Bo CHEN; Su Hao LO Tensin is a focal-adhesion molecule that binds to actin filaments and interacts with phosphotyrosine-containing proteins. To analyse tensin's function in mammals, we have cloned tensin cDNAs from human and cow. The isolated approx...