...Peter Delannoy; Dean R. Tolan; Miguel A. Lanaspa; Iñigo San Millán; So Young Bae; Richard J. Johnson There is an increasing interest in the role of fructose as a major driver of non-alcoholic fatty liver disease (NAFLD), and it is linked closely with the intake of sugar. However, there has also...

...Takuji Suzuki; Veronique Douard; Kazuki Mochizuki; Toshinao Goda; Ronaldo P. Ferraris Metabolic complications arising from excessive fructose consumption are increasing dramatically even in young children, but little is known about ontogenetic mechanisms regulating Glut5 [glucose transporter 5...

... glycation end-products) in various tissues, including the lens. Nevertheless, glycation of α-crystallin with various sugars has resulted in divergent results. In the present in vitro study, we have investigated the effect of glucose, fructose, G6P (glucose 6-phosphate) and MGO (methylglyoxal), which...

...-deoxyglucosone [ 20 ]. If so, the fructose-fed diabetic KO mouse would develop complications at a lower rate than the wild-type. In summary, Veiga-da-Cunha and colleagues [ 8 ] have achieved a major milestone. Obviously, the various experiments proposed above represent only the tip of the investigation...

...Florence GOUYON; Cercina ONESTO; Veronique DALET; Gilles PAGES; Armelle LETURQUE; Edith BROT-LAROCHE In intestinal cells, levels of the fructose transporter GLUT5 are increased by glucose and to a greater extent by fructose. We investigated the mechanism by which fructose increases GLUT5 expression...

... identified on SDS/polyacrylamide gels. In addition, the whole bovine lenses were incubated with 10 mM fructose and glucose for 3 and 6 days. The glycated proteins from the water-soluble fractions in parallel with the radioactive fractions were separated by affinity chromatography, and were identified further...

...Jing YANG; James DOWDEN; Arnaud TATIBOUËT; Yasumaru HATANAKA; Geoffrey D. HOLMAN The GLUT5 transporter catalyses the specific uptake of d -fructose and can accept this hexose in its furanose and pyranose ring forms. The transporter does not accept fructose epimers and has very limited tolerance...

...Ronaldo P. FERRARIS The Na + -dependent glucose transporter SGLT1 and the facilitated fructose transporter GLUT5 absorb sugars from the intestinal lumen across the brush-border membrane into the cells. The activity of these transport systems is known to be regulated primarily by diet...