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Keywords: gain-of-function
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Articles

Mapping the ligand-binding pocket of integrin α5β1 using a gain-of-function approach

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A. Paul Mould, Ewa J. Koper, Adam Byron, Grit Zahn, Martin J. Humphries
Journal: Biochemical Journal
Biochem J (2009) 424 (2): 179–189.
https://doi.org/10.1042/BJ20090992
Published: 11 November 2009
.... Using a gain-of-function analysis involving swapping regions of the zebrafish integrin α5 subunit with the corresponding regions of human α5 we show that blades 1–4 of the β-propeller are required for human fibronectin recognition, suggesting that fibronectin binding involves a broad interface...
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Includes: Supplementary data
Articles

Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies

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Clare J. McCLEVERTY, Robert C. LIDDINGTON
Journal: Biochemical Journal
Biochem J (2003) 372 (1): 121–127.
https://doi.org/10.1042/bj20021273
Published: 15 May 2003
... conformation and hence ligand affinity. 1 To whom correspondence should be addressed (e-mail [email protected] ). 12 8 2002 27 2 2003 3 3 2003 3 3 2003 The Biochemical Society, London ©2003 2003 A domain allostery gain-of-function I domain integrin...
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