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Keywords: gambogic acid
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Articles

Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways

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Jianjun Ma, Yan Ma, Xuqiang Liu, Shuai Chen, Chao Liu, An Qin, Shunwu Fan
Journal: Biochemical Journal
Biochem J (2015) 469 (3): 399–408.
https://doi.org/10.1042/BJ20150151
Published: 23 July 2015
... have advantages over traditional drugs. In the present paper, we report that the natural compound GBA (gambogic acid), which is bioavailable, effective and less toxic, inhibits osteoclast formation, thereby attenuating osteoclastic bone resorption in vitro . Further in vivo studies demonstrated...
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Articles

Gambogic acid covalently modifies IκB kinase-β subunit to mediate suppression of lipopolysaccharide-induced activation of NF-κB in macrophages

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Umamaheshwari D. Palempalli, Ujjawal Gandhi, Parisa Kalantari, Hema Vunta, Ryan J. Arner, Vivek Narayan, Anand Ravindran, K. Sandeep Prabhu
Journal: Biochemical Journal
Biochem J (2009) 419 (2): 401–409.
https://doi.org/10.1042/BJ20081482
Published: 27 March 2009
...Umamaheshwari D. Palempalli; Ujjawal Gandhi; Parisa Kalantari; Hema Vunta; Ryan J. Arner; Vivek Narayan; Anand Ravindran; K. Sandeep Prabhu GA (gambogic acid) is a polyprenylated xanthone abundant in the resin of Garcinia morella and Garcinia hanburyi with a long history of use as a complementary...
View articletitled, Gambogic acid covalently modifies IκB kinase-β subunit to mediate suppression of lipopolysaccharide-induced activation of NF-κB in macrophages
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