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Keywords: gap junction
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Biochem J (2024) 481 (22): 1639–1655.
Published: 08 November 2024
... of molecular defects including impaired gap junction (GJ) formation, dysregulated hemichannel and/or GJ channel function, cytotoxicity, dominant disruption of co-expressed connexins, and/or altered turnover kinetics. Here, we review the progress made in understanding the genetic and molecular basis of EKVP...
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Articles
Biochem J (2015) 465 (2): 295–303.
Published: 06 January 2015
... activity through the STAT3 and TGF-β 1 pathways. cAMP EPAC1 gap junction guanine-nucleotide-exchange factor regulatory T-cell STAT3 TGF-β1 Regulatory T-cells (Tregs) are T-lymphocytes that possess a general suppressor function and play an essential role in both adaptive and innate...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (3): 371–381.
Published: 10 July 2014
... structures that are commonplace for Cx43 (connexin 43) when organized into gap junction plaques [ 27 ]. Figure 2 Life cycle of pannexins Pannexins are thought to be co-translationally inserted into the endoplasmic reticulum, where they are subjected to high-mannose glycosylation (small white chains...
Articles
Biochem J (2014) 457 (3): 441–449.
Published: 10 January 2014
... formation, skin diseases, oogenesis, breast cancer and vision [ 14 – 21 ]. In all of these scenarios the expression of the G60S mutant was found to be dominant to the co-expressed endogenous Cx43, resulting in a greater than 50% reduction in Cx43-based gap junction coupling. Remarkably, this finding did...
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Biochem J (2011) 438 (2): 245–254.
Published: 12 August 2011
...Claire A. Scott; David P. Kelsell Cx (connexin) proteins are components of gap junctions which are aqueous pores that allow intercellular exchange of ions and small molecules. Mutations in Cx genes are linked to a range of human disorders. In the present review we discuss mutations in β-Cx genes...
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Biochem J (2011) 437 (2): 255–267.
Published: 28 June 2011
...Steve Catarino; José S. Ramalho; Carla Marques; Paulo Pereira; Henrique Girão Gap junctions are specialized cell–cell contacts that provide direct intercellular communication between eukaryotic cells. The tyrosine-sorting signal (YXXØ), present at amino acids 286–289 of Cx43 (connexin43), has been...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2011) 436 (1): 35–43.
Published: 27 April 2011
...Agustín D. Martínez; Jaime Maripillán; Rodrigo Acuña; Peter J. Minogue; Viviana M. Berthoud; Eric C. Beyer Oligomerization of connexins is a critical step in gap junction channel formation. Some members of the connexin family can oligomerize with other members and form functional heteromeric...
Includes: Supplementary data
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Articles
Biochem J (2010) 429 (3): 473–483.
Published: 14 July 2010
... to the identity of each cell line was asked to count the number of punctate structures present at sites of cell–cell apposition in each image. A gap junction plaque was defined as a punctate immunolabelled structure of a size greater than 0.1 μm. The total number of nuclei (as revealed by DAPI staining) was also...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (2): 261–272.
Published: 27 March 2009
...Joell L. Solan; Paul D. Lampe Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical roles in embryonic development, co-ordinated contraction of excitable cells, tissue homoeostasis, normal cell growth and differentiation. Phosphorylation of connexin43, the most...
Includes: Multimedia, Supplementary data
Articles
Articles
Biochem J (2006) 394 (3): 527–543.
Published: 24 February 2006
...Dale W. Laird Evaluation of the human genome suggests that all members of the connexin family of gap-junction proteins have now been successfully identified. This large and diverse family of proteins facilitates a number of vital cellular functions coupled with their roles, which range from...
Articles
Biochem J (2006) 393 (1): 59–67.
Published: 12 December 2005
...Edward Leithe; Andreas Brech; Edgar Rivedal Gap junctions are plasma membrane areas enriched in channels that provide direct intercellular communication. Gap junctions have a high turnover rate; however, the mechanisms by which gap junctions are degraded are incompletely understood. In the present...
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