Page 1 | Search Results | Biochemical Journal

1-50 of 118

Sort by

Sort Order Select

Articles

Selective degradation of plasmid-derived mRNAs by MCPIP1 RNase

Yisong Qian, Xiuzhen Li, Ruidong Miao, Shufeng Liu, Hong-Bo Xin, Xiaotian Huang, Tony T. Wang, Mingui Fu

Biochem J (2019) 476 (19): 2927–2938.

https://doi.org/10.1042/BCJ20190646

Published: 11 October 2019

... genes incorporated into the host genome in a stable cell line or the global gene expression of host genome. This ability is not associated with PKR/RNase L system, as PKR inhibitors does not block MCPIP1-mediated mRNA degradation of exogenously transfected genes. Lastly, expression of MCPIP1 suppressed...

View article titled, Selective degradation of plasmid-derived mRNAs by MCPIP1 RNase

Articles

Spotlight on the transglutaminase 2 gene: a focus on genomic and transcriptional aspects

Nicoletta Bianchi, Simone Beninati, Carlo M. Bergamini

Biochem J (2018) 475 (9): 1643–1667.

https://doi.org/10.1042/BCJ20170601

Published: 15 May 2018

...Nicoletta Bianchi; Simone Beninati; Carlo M. Bergamini The type 2 isoenzyme is the most widely expressed transglutaminase in mammals displaying several intra- and extracellular activities depending on its location (protein modification, modulation of gene expression, membrane signalling...

View article titled, Spotlight on the transglutaminase 2 gene: a focus on genomic and transcriptional aspects

Includes: Supplementary data

Articles

miRNA let-7 expression is regulated by glucose and TNF-α by a remote upstream promoter

Mutsumi Katayama, Rasmus J.O. Sjögren, Brendan Egan, Anna Krook

Biochem J (2015) 472 (2): 147–156.

https://doi.org/10.1042/BJ20150224

Published: 13 November 2015

... muscle biopsies as described [ 11 ]. Cell cultures were maintained at 37°C under 7.5% CO 2 as myoblast cells and myoblast cells were used to transfect promoter plasmids. To measure gene expression of human skeletal muscle cells, myoblast cells were differentiated into myotubes. To initiate...

View article titled, miRNA let-7 expression is regulated by glucose and TNF-α by a remote upstream promoter

Articles

Regulation of IGFBP-2 expression during fasting

Hye Suk Kang, Mi-Young Kim, Seung-Jae Kim, Jae-Ho Lee, Yong-Deuk Kim, Young-Kyo Seo, Jae-Hoon Bae, Goo-Taeg Oh, Dae-Kyu Song, Yong-Ho Ahn, Seung-Soon Im

Biochem J (2015) 467 (3): 453–460.

https://doi.org/10.1042/BJ20141248

Published: 17 April 2015

... Igfbp-2 and PPARα expression levels were increased. Wy14643, a selective PPARα agonist, significantly induced Igfbp-2 gene expression in primary cultured hepatocytes. However, Igfbp-2 gene expression in Pparα null mice was not affected by fasting or Wy14643. In addition, through transient...

View article titled, Regulation of IGFBP-2 expression during fasting

Articles

Characterization of excitation–contraction coupling components in human extraocular muscles

Marijana Sekulic-Jablanovic, Anja Palmowski-Wolfe, Francesco Zorzato, Susan Treves

Biochem J (2015) 466 (1): 29–36.

https://doi.org/10.1042/BJ20140970

Published: 06 February 2015

...). calcium homoeostasis excitation–contraction coupling gene expression Extraocular muscles (EOMs) are among the fastest and most fatigue-resistant skeletal muscles [ 1 ]. More than 20 years ago, they were categorized as a separate group of muscles or ‘allotype’ since they represent a unique group...

View article titled, Characterization of excitation–contraction coupling components in human extraocular muscles

Includes: Supplementary data

Articles

PIKfyve, MTMR3 and their product PtdIns5 P regulate cancer cell migration and invasion through activation of Rac1

Angela Oppelt, Ellen M. Haugsten, Tobias Zech, Håvard E. Danielsen, Anita Sveen, Viola H. Lobert, Rolf I. Skotheim, Jørgen Wesche

Biochem J (2014) 461 (3): 383–390.

https://doi.org/10.1042/BJ20140132

Published: 10 July 2014

... by the lipid PtdIns5 P produced by PIKfyve and MTMR3 and that the activities of these druggable enzymes are important for cancer cell migration and invasion. analysis software cell migration gene expression myotubularin-related protein 3 (MTMR3) PIKfyve PtdIns5 P We have shown previously...

View article titled, PIKfyve, MTMR3 and their product PtdIns5 P regulate cancer cell migration and invasion through activation of Rac1

Includes: Supplementary data

Articles

Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization

Ori Rokach, Nina D. Ullrich, Martin Rausch, Vincent Mouly, Haiyan Zhou, Francesco Muntoni, Francesco Zorzato, Susan Treves

Biochem J (2013) 455 (2): 169–177.

https://doi.org/10.1042/BJ20130698

Published: 27 September 2013

... coupling of an immortalized human skeletal muscle cell line and show the potential application of this cell line as a platform for the screaning of drugs to treating defects caused by mutations in genes involved in Ca 2+ regulation. excitation–contraction coupling gene expression immortalized...

View article titled, Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization

Articles

Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

Michael Aregger, Victoria H. Cowling

Biochem J (2013) 455 (1): 67–73.

https://doi.org/10.1042/BJ20130378

Published: 13 September 2013

...Michael Aregger; Victoria H. Cowling Gene expression in eukaryotes is dependent on the mRNA methyl cap which mediates mRNA processing and translation initiation. Synthesis of the methyl cap initiates with the addition of 7-methylguanosine to the initiating nucleotide of RNA pol II (polymerase II...

View article titled, Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

Articles

Flavanoids induce expression of the suppressor of cytokine signalling 3 ( SOCS3 ) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells

Jolanta Wiejak, Julia Dunlop, Simon P. Mackay, Stephen J. Yarwood

Biochem J (2013) 454 (2): 283–293.

https://doi.org/10.1042/BJ20130481

Published: 09 August 2013

...Jolanta Wiejak; Julia Dunlop; Simon P. Mackay; Stephen J. Yarwood The atherogenic cytokine IL-6 (interleukin-6) induces pro-inflammatory gene expression in VECs (vascular endothelial cells) by activating the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3) signalling...

View article titled, Flavanoids induce expression of the suppressor of cytokine signalling 3 ( SOCS3 ) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells

Includes: Supplementary data

Articles

Prediction of hammerhead ribozyme intracellular activity with the catalytic core fingerprint

Marta Magdalena Gabryelska, Eliza Wyszko, Maciej Szymański, Mariusz Popenda, Jan Barciszewski

Biochem J (2013) 451 (3): 439–451.

https://doi.org/10.1042/BJ20121761

Published: 12 April 2013

...Marta Magdalena Gabryelska; Eliza Wyszko; Maciej Szymański; Mariusz Popenda; Jan Barciszewski Hammerhead ribozyme is a versatile tool for down-regulation of gene expression in vivo . Owing to its small size and high activity, it is used as a model for RNA structure–function relationship studies...

View article titled, Prediction of hammerhead ribozyme intracellular activity with the catalytic core fingerprint

Includes: Supplementary data

Articles

Transcriptional networks driving enhancer function in the CFTR gene

Jenny L. Kerschner, Ann Harris

Biochem J (2012) 446 (2): 203–212.

https://doi.org/10.1042/BJ20120693

Published: 14 August 2012

... Journal compilation © 2012 Biochemical Society 2012 cis- acting regulatory element cystic fibrosis transmembrane conductance regulator ( CFTR ) enhancer gene expression transcriptional network The recruitment of TFs (transcription factors) and chromatin remodellers to cis- regulatory...

View article titled, Transcriptional networks driving enhancer function in the CFTR gene

Includes: Supplementary data

Articles

The role of the Snf1 kinase in the adaptive response of Saccharomyces cerevisiae to alkaline pH stress

Antonio Casamayor, Raquel Serrano, María Platara, Carlos Casado, Amparo Ruiz, Joaquín Ariño

Biochem J (2012) 444 (1): 39–49.

https://doi.org/10.1042/BJ20112099

Published: 26 April 2012

... was assessed by denaturing 0.8% agarose gel electrophoresis, and RNA quantification was performed by measuring A 260 in a BioPhotometer (Eppendorf). gene expression glucose starvation Snf1 stress tolerance yeast Fermentation of sugars, preferably glucose, is the favoured energy source...

View article titled, The role of the Snf1 kinase in the adaptive response of Saccharomyces cerevisiae to alkaline pH stress

Includes: Supplementary data

Articles

Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2

Henna-Kaisa Jyrkkänen, Suvi Kuosmanen, Merja Heinäniemi, Heidi Laitinen, Emilia Kansanen, Eero Mella-Aho, Hanna Leinonen, Seppo Ylä-Herttuala, Anna-Liisa Levonen

Biochem J (2011) 440 (2): 167–174.

https://doi.org/10.1042/BJ20110526

Published: 14 November 2011

... and that induction of BACH1 by Nrf2 may serve as a feedback-inhibitory mechanism for ARE-mediated gene regulation. © The Authors Journal compilation © 2011 Biochemical Society 2011 antioxidant-response element (ARE) BTB and CNC homology 1 (BACH1) gene expression gene regulation nuclear factor-erythroid 2...

View article titled, Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2

Includes: Supplementary data

Articles

CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a

Huan Qiao, James M. May

Biochem J (2011) 440 (1): 73–84.

https://doi.org/10.1042/BJ20110392

Published: 27 October 2011

... to the manufacturer's instructions. CpG gene expression methylation nuclear factor Y (NF-Y) sodium–vitamin C co-transporter 2 (SVCT2) upstream stimulating factor (USF) Human cell lines HeLa (cervical cancer), U2OS (osteosarcoma), HepG2 (liver carcinoma), SHS-Y5Y (neuroblastoma), HT1080...

View article titled, CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a

Includes: Supplementary data

Articles

The role of the protein kinase A pathway in the response to alkaline pH stress in yeast

Carlos Casado, Asier González, Maria Platara, Amparo Ruiz, Joaquín Ariño

Biochem J (2011) 438 (3): 523–533.

https://doi.org/10.1042/BJ20110607

Published: 26 August 2011

... and that change in the activity of the PKA pathway alters tolerance to alkaline pH. The results of the present paper also indicate that the adaptive response to high pH involves PKA-regulated Msn2/Msn4-mediated gene remodelling. Activation of PKA has a major impact on gene expression. Consequently, several...

View article titled, The role of the protein kinase A pathway in the response to alkaline pH stress in yeast

Includes: Supplementary data

Articles

GATA-4 transcription factor regulates hepatic hepcidin expression

Marie-Laure Island, Nadia Fatih, Patricia Leroyer, Pierre Brissot, Olivier Loreal

Biochem J (2011) 437 (3): 477–482.

https://doi.org/10.1042/BJ20110225

Published: 13 July 2011

... macrophages, enterocytes and hepatocytes towards plasma. Abnormal levels of hepcidin expression alter plasma iron parameters and lead to iron metabolism disorders. Understanding the mechanisms controlling hepcidin ( HAMP encodes hepcidin) gene expression is therefore an important goal. We identified...

View article titled, GATA-4 transcription factor regulates hepatic hepcidin expression

Articles

Transcriptional regulation of the intestinal luminal Na + and Cl − transporters

Jaleh Malakooti, Seema Saksena, Ravinder K. Gill, Pradeep K. Dudeja

Biochem J (2011) 435 (2): 313–325.

https://doi.org/10.1042/BJ20102062

Published: 29 March 2011

... on the transcriptional regulation of the recently identified NHE8 isoform is also highlighted. Therefore the present review bridges a gap in our knowledge of the transcriptional mechanisms underlying the alterations in the gene expression of intestinal epithelial luminal membrane Na + and Cl − transporters involved...

View article titled, Transcriptional regulation of the intestinal luminal Na + and Cl − transporters

Articles

Expression and functional validation of new p38α transcriptional targets in tumorigenesis

Aneta Swat, Ignacio Dolado, Ana Igea, Gonzalo Gomez-Lopez, David G. Pisano, Ana Cuadrado, Angel R. Nebreda

Biochem J (2011) 434 (3): 549–558.

https://doi.org/10.1042/BJ20101410

Published: 24 February 2011

.... Surprisingly, most tumour suppressor mechanisms co-ordinated by p38α have been reported to occur at the post-translational level. This contrasts with the important role of p38α in the regulation of transcription and the profound changes in gene expression that normally occur during tumorigenesis. We have...

View article titled, Expression and functional validation of new p38α transcriptional targets in tumorigenesis

Includes: Supplementary data

Articles

p65 controls NF-κB activity by regulating cellular localization of IκBβ

Taras Valovka, Michael O. Hottiger

Biochem J (2011) 434 (2): 253–263.

https://doi.org/10.1042/BJ20101220

Published: 11 February 2011

... 8 2010 5 11 2010 16 12 2010 16 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cellular localization gene expression inhibitory κB β (IκBβ) nuclear factor κB (NF-κB) tumour necrosis factor α (TNFα) NF-κB (nuclear factor κB) is a homo...

View article titled, p65 controls NF-κB activity by regulating cellular localization of IκBβ

Includes: Supplementary data

Articles

PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone

Liuluan Zhu, Yaojun Ke, Di Shao, Ying Cui, Aijun Qiao, Xiaojun Liu, Fude Fang, Yongsheng Chang

Biochem J (2010) 432 (3): 473–486.

https://doi.org/10.1042/BJ20100460

Published: 25 November 2010

... tissue axis. In the present study, we show that PGC-1α [PPARγ (peroxisome-proliferator-activated receptor γ) co-activator 1α] interacts with and co-activates SF-1 to induce LH β (luteinizing hormone β) and α GSU (α-glycoprotein subunit) gene expression, subsequently leading to the increased secretion...

View article titled, PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone

Includes: Supplementary data

Articles

A nuclear glutathione cycle within the cell cycle

Pedro Diaz Vivancos, Tonja Wolff, Jelena Markovic, Federico V. Pallardó, Christine H. Foyer

Biochem J (2010) 431 (2): 169–178.

https://doi.org/10.1042/BJ20100409

Published: 28 September 2010

.... Moreover, GSH recruitment and sequestration in the nucleus during the G 1 - and S-phases of the cell cycle has a profound impact on cellular redox homoeostasis and on gene expression. For example, the abundance of transcripts encoding stress and defence proteins is decreased when GSH is sequestered...

View article titled, A nuclear glutathione cycle within the cell cycle

Includes: Multimedia, Supplementary data

Articles

Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site

Fabrizio Damiano, Simone Alemanno, Gabriele V. Gnoni, Luisa Siculella

Biochem J (2010) 429 (3): 603–612.

https://doi.org/10.1042/BJ20091827

Published: 14 July 2010

... and pBKS1cLuc, respectively. gene expression internal ribosome entry site (IRES) sterol-regulatory-element-binding protein-1 (SREBP-1) translational regulation unfolded protein response (UPR) 5′-untranslated region (5′-UTR) Lipid homoeostasis in vertebrate cells is regulated by a family...

View article titled, Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site

Articles

Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARγ

Francesca Aguiló, Nuria Camarero, Joana Relat, Pedro F. Marrero, Diego Haro

Biochem J (2010) 427 (2): 255–264.

https://doi.org/10.1042/BJ20090851

Published: 29 March 2010

...Francesca Aguiló; Nuria Camarero; Joana Relat; Pedro F. Marrero; Diego Haro In the cytosol of lipogenic tissue, ketone bodies are activated by AACS (acetoacetyl-CoA synthetase) and incorporated into cholesterol and fatty acids. AACS gene expression is particularly abundant in white adipose tissue...

View article titled, Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARγ

Articles

Human Ccr4–Not complexes contain variable deadenylase subunits

Nga-Chi Lau, Annemieke Kolkman, Frederik M. A. van Schaik, Klaas W. Mulder, W. W. M. Pim Pijnappel, Albert J. R. Heck, H. Th. Marc Timmers

Biochem J (2009) 422 (3): 443–453.

https://doi.org/10.1042/BJ20090500

Published: 27 August 2009

... 26 6 2009 26 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Ccr4–Not complex gene expression mRNA deadenylation proteomics transcription regulation The evolutionarily conserved Ccr4–Not complex is important for multiple cellular functions...

View article titled, Human Ccr4–Not complexes contain variable deadenylase subunits

Includes: Supplementary data

Articles

Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts

Anne Uimari, Tuomo A. Keinänen, Anne Karppinen, Patrick Woster, Pekka Uimari, Juhani Jänne, Leena Alhonen

Biochem J (2009) 422 (1): 101–109.

https://doi.org/10.1042/BJ20090411

Published: 29 July 2009

... protein (EGFP) gene expression polyamines spermine analogues spermidine/spermine N 1 -acetyltransferase (SSAT) The polyamines putrescine, spermidine and spermine are essential in central cellular processes including proliferation and differentiation [ 1 , 2 ]. The intracellular polyamine pools...

View article titled, Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts

Articles

KLF4 positively regulates human ghrelin expression

Hyo Jung Lee, Young Mi Kang, Chang Suk Moon, Myung Kuk Joe, Joo Hyun Lim, Young Ho Suh, Jihyun Song, Myeong Ho Jung

Biochem J (2009) 420 (3): 403–411.

https://doi.org/10.1042/BJ20081850

Published: 27 May 2009

... © The Authors Journal compilation © 2009 Biochemical Society 2009 gastrointestinal tissue gene expression ghrelin Krüppel-like factor 4 (KLF4) promoter The gastrointestinal tract plays a crucial role in homoeostasis through its effects on the digestion, absorption and assimilation...

View article titled, KLF4 positively regulates human ghrelin expression

Articles

In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana

Allison L. Gregory, Brenden A. Hurley, Hue T. Tran, Alexander J. Valentine, Yi-Min She, Vicki L. Knowles, William C. Plaxton

Biochem J (2009) 420 (1): 57–65.

https://doi.org/10.1042/BJ20082397

Published: 28 April 2009

..., ON, Canada, M5S 1A8. Arabidopsis gene expression P i starvation mass spectrometry phosphoenolpyruvate carboxylase kinase (PPCK) protein phosphorylation PEPC [PEP (phosphoenolpyruvate) carboxylase] (EC 4.1.1.31) is a ubiquitous cytosolic enzyme in vascular plants that is also distributed...

View article titled, In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana

Includes: Supplementary data

Articles

Functional analysis of rat liver citrate carrier promoter: differential responsiveness to polyunsaturated fatty acids

Fabrizio Damiano, Gabriele V. Gnoni, Luisa Siculella

Biochem J (2009) 417 (2): 561–571.

https://doi.org/10.1042/BJ20081082

Published: 23 December 2008

... differential mechanisms in the Cic gene regulation by different PUFA. citrate carrier gene expression lipogenesis polyunsaturated fatty acids (PUFA) rat liver sterol regulatory element-binding protein-1 (SREBP-1) CiC (citrate carrier), also known as tricarboxylate carrier, is a mitochondrial...

View article titled, Functional analysis of rat liver citrate carrier promoter: differential responsiveness to polyunsaturated fatty acids

Articles

High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours

Helena Carén, Frida Abel, Per Kogner, Tommy Martinsson

Biochem J (2008) 416 (2): 153–159.

https://doi.org/10.1042/BJ20081834

Published: 12 November 2008

... correspondence should be addressed (email [email protected] ). 11 9 2008 6 10 2008 7 10 2008 7 10 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 anaplastic lymphoma kinase (ALK) gene amplification gene expression mutation neuroblastoma...

View article titled, High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours

Articles

PPR (pentatricopeptide repeat) proteins in mammals: important aids to mitochondrial gene expression

Robert N. Lightowlers, Zofia M. A. Chrzanowska-Lightowlers

Biochem J (2008) 416 (1): e5–e6.

https://doi.org/10.1042/BJ20081942

Published: 28 October 2008

... of the mitochondrial genome. 1 To whom correspondence should be addressed (email [email protected] ). 25 9 2008 26 9 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 gene expression mitochondrion pentatricopeptide repeat protein post-transcriptional...

View article titled, PPR (pentatricopeptide repeat) proteins in mammals: important aids to mitochondrial gene expression

Articles

Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the NF-κB family member RelB

Julia Leidner, Lysann Palkowitsch, Uta Marienfeld, Dietmar Fischer, Ralf Marienfeld

Biochem J (2008) 416 (1): 117–127.

https://doi.org/10.1042/BJ20080432

Published: 28 October 2008

... ). 22 2 2008 7 7 2008 11 7 2008 11 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 co-factor gene expression nuclear factor κB (NF-κB) protein stability RelB ubiquitination The transcription factor NF-κB (nuclear factor κB) plays...

View article titled, Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the NF-κB family member RelB

Includes: Supplementary data

Articles

Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p

Yulia Ilina, Ewa Sloma, Ewa Maciaszczyk-Dziubinska, Marian Novotny, Michael Thorsen, Robert Wysocki, Markus J. Tamás

Biochem J (2008) 415 (3): 467–475.

https://doi.org/10.1042/BJ20080713

Published: 15 October 2008

... the importance of the TTAATAA core element and pin-point nucleotides that flank this element as crucial for Yap8p binding and in vivo activation of ACR3 expression. A genome-wide search for this element combined with global gene expression analysis indicates that the principal function of Yap8p is to control...

View article titled, Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p

Includes: Supplementary data

Articles

Regulation of gene expression in the nervous system

Lezanne Ooi, Ian C. Wood

Biochem J (2008) 414 (3): 327–341.

https://doi.org/10.1042/BJ20080963

Published: 27 August 2008

... in the mature nervous system to maintain appropriate gene-expression patterns in differentiated cells. Underpinning the function of the nervous system is its plasticity in response to external stimuli, and many transcription factors are involved in regulating gene expression in response to neuronal activity...

View article titled, Regulation of gene expression in the nervous system

Includes: Multimedia, Supplementary data

Articles

Structure, mechanism and regulation of pyruvate carboxylase

Sarawut Jitrapakdee, Martin St Maurice, Ivan Rayment, W. Wallace Cleland, John C. Wallace, Paul V. Attwood

Biochem J (2008) 413 (3): 369–387.

https://doi.org/10.1042/BJ20080709

Published: 15 July 2008

.... 3 Correspondence can be addressed to either of these authors (email [email protected] or [email protected] ). 7 4 2008 7 5 2008 7 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 acetyl-CoA biotin gene expression...

View article titled, Structure, mechanism and regulation of pyruvate carboxylase

Articles

A functional link between housekeeping selenoproteins and phase II enzymes

Aniruddha Sengupta, Bradley A. Carlson, James A. Weaver, Sergey V. Novoselov, Dmitri E. Fomenko, Vadim N. Gladyshev, Dolph L. Hatfield

Biochem J (2008) 413 (1): 151–161.

https://doi.org/10.1042/BJ20080277

Published: 12 June 2008

... correspondence should be addressed (email [email protected] ). 30 1 2008 13 3 2008 28 3 2008 28 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 gene expression liver microarray selenocysteine (Sec) tRNA Trsp knockout xenobiotic...

View article titled, A functional link between housekeeping selenoproteins and phase II enzymes

Articles

AcpA, a member of the GPR1/FUN34/YaaH membrane protein family, is essential for acetate permease activity in the hyphal fungus Aspergillus nidulans

Xavier Robellet, Michel Flipphi, Sylvine Pégot, Andrew P. MacCabe, Christian Vélot

Biochem J (2008) 412 (3): 485–493.

https://doi.org/10.1042/BJ20080124

Published: 28 May 2008

... 27 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 acetate Aspergillus nidulans gene expression GPR1/FUN34/YaaH protein family monocarboxylate transport Like other filamentous fungi, Aspergillus nidulans is able to grow on two-carbon compounds...

View article titled, AcpA, a member of the GPR1/FUN34/YaaH membrane protein family, is essential for acetate permease activity in the hyphal fungus Aspergillus nidulans

Articles

Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E 2 release via C/EBPβ in human bronchial epithelial cells

Donghong He, Viswanathan Natarajan, Randi Stern, Irina A. Gorshkova, Julian Solway, Ernst Wm. Spannhake, Yutong Zhao

Biochem J (2008) 412 (1): 153–162.

https://doi.org/10.1042/BJ20071649

Published: 25 April 2008

... 72 h after transfection and analysed using Western blotting as above. bioactive phospholipid gene expression receptor tyrosine kinase (RTK) signal transduction transcription factor A classical role of human airway epithelium is to function as a passive barrier between inhaled...

View article titled, Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E 2 release via C/EBPβ in human bronchial epithelial cells

Articles

Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells

Jenny Kaeding, Emmanuel Bouchaert, Julie Bélanger, Patrick Caron, Sarah Chouinard, Mélanie Verreault, Olivier Larouche, Georges Pelletier, Bart Staels, Alain Bélanger, Olivier Barbier

Biochem J (2008) 410 (2): 245–253.

https://doi.org/10.1042/BJ20071136

Published: 12 February 2008

... compilation © 2008 Biochemical Society 2008 androgen metabolism farnesoid X receptor (FXR) gene expression glucuronidation prostate UDP-glucuronosyltransferase (UGT) 2B15 (UGT2B15) and UGT2B17 The glucuronidation reaction, which corresponds to the transfer of the polar glucuronosyl group...

View article titled, Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells

Includes: Supplementary data

Articles

Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats

Christopher R. Wilson, Mai K. Tran, Katrina L. Salazar, Martin E. Young, Heinrich Taegtmeyer

Biochem J (2007) 406 (3): 457–467.

https://doi.org/10.1042/BJ20070392

Published: 29 August 2007

... oxidation and a cassette of fatty acid-responsive genes. cardiac function cardiac metabolism diet-induced obesity futile cycling gene expression triacylglycerol Metabolic adaptation to changes in the physiological environment is a requisite for normal muscle function. The contractile...

View article titled, Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats

Articles

BHLH32 modulates several biochemical and morphological processes that respond to P i starvation in Arabidopsis

Zhi-Hui Chen, Gillian A. Nimmo, Gareth I. Jenkins, Hugh G. Nimmo

Biochem J (2007) 405 (1): 191–198.

https://doi.org/10.1042/BJ20070102

Published: 13 June 2007

... differentiation [TTG1 (TRANSPARENT TESTA GLABRA1), GL3 (GLABRA3) and EGL3 (ENHANCER OF GL3)] positively regulate PPCK gene expression in response to P i starvation. BHLH32 can physically interact with TTG1 and GL3. We propose that BHLH32 interferes with the function of TTG1-containing complexes and thereby...

View article titled, BHLH32 modulates several biochemical and morphological processes that respond to P i starvation in Arabidopsis

Articles

A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction

Sawako Shindo, Satoshi Numazawa, Takemi Yoshida

Biochem J (2007) 401 (3): 735–741.

https://doi.org/10.1042/BJ20061238

Published: 12 January 2007

... gene expression. Immunoblot analysis using an antibody which recognizes Thr-172-phosphorylated AMPKα1/2 revealed phenobarbital-induced AMPK activation in rat and mouse livers as well. Phenobarbital, however, failed to increase the liver phospho-AMPK level of tumour-bearing rats in which CAR nuclear...

View article titled, A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction

Articles

Involvement of the ubiquitous Oct-1 transcription factor in hormonal induction of β-casein gene expression

Bing Dong, Feng-Qi Zhao

Biochem J (2007) 401 (1): 57–64.

https://doi.org/10.1042/BJ20060570

Published: 11 December 2006

... biochemical evidence that the ubiquitous Oct-1 transcription factor may be involved in hormonally regulated, tissue-specific β-casein gene expression. Expression of the major milk protein β-casein gene in the mammary gland is primarily regulated at the transcriptional level under the control...

View article titled, Involvement of the ubiquitous Oct-1 transcription factor in hormonal induction of β-casein gene expression

Articles

Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region

Lan Liu, Xin Guo, Jaladanki N. Rao, Tongtong Zou, Bernard S. Marasa, Jie Chen, Jose Greenspon, Robert A. Casero, Jr, Jian-Ying Wang

Biochem J (2006) 398 (2): 257–267.

https://doi.org/10.1042/BJ20060217

Published: 15 August 2006

... in a plastic sheet protector and exposed to autoradiography film for 30 or 60 s. cell proliferation α-difluoromethylornithine (DFMO) gene expression intestinal epithelium cell (IEC) ornithine decarboxylase (ODC) transcriptional repression The epithelium of the mammalian intestine is a self...

View article titled, Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region

Articles

TEF-1 and C/EBPβ are major p38α MAPK-regulated transcription factors in proliferating cardiomyocytes

Concetta Ambrosino, Tomoko Iwata, Claudio Scafoglio, Massimo Mallardo, Rüdiger Klein, Angel R. Nebreda

Biochem J (2006) 396 (1): 163–172.

https://doi.org/10.1042/BJ20051502

Published: 26 April 2006

... be addressed (email [email protected] ). 12 9 2005 1 2 2006 21 2 2006 21 2 2006 The Biochemical Society, London 2006 cardiomyocyte collagen extracellular matrix (ECM) gene expression p38 MAPK transcription factor The p38 MAPK (mitogen-activated protein kinase...

View article titled, TEF-1 and C/EBPβ are major p38α MAPK-regulated transcription factors in proliferating cardiomyocytes

Includes: Supplementary data

Articles

Gene expression patterns and catalytic properties of UDP-D-glucose 4-epimerases from barley (Hordeum vulgare L.)

Qisen Zhang, Maria Hrmova, Neil J. Shirley, Jelle Lahnstein, Geoffrey B. Fincher

Biochem J (2006) 394 (1): 115–124.

https://doi.org/10.1042/BJ20051329

Published: 27 January 2006

... AY943955, AY943956 and AY943954. 15 8 2005 1 11 2005 3 11 2005 3 11 2005 The Biochemical Society, London 2006 barley gene expression nucleotide sugar plant cell wall UDP- D -glucose 4-epimerase (UGE) UDP-GlcNAc UGE (UDP-Glc 4-epimerase or UDP-Gal 4-epimerase...

View article titled, Gene expression patterns and catalytic properties of UDP-D-glucose 4-epimerases from barley (Hordeum vulgare L.)

Articles

Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors

Vito Iacobazzi, Vittoria Infantino, Paola Costanzo, Paola Izzo, Ferdinando Palmieri

Biochem J (2005) 391 (3): 613–621.

https://doi.org/10.1042/BJ20050776

Published: 25 October 2005

.... These findings may provide insight into control of PiC gene expression in different cell types and under different growth conditions. To our knowledge, this is the first study to analyse the regulation of the PiC gene expression in any cell. 1 To whom correspondence should be addressed (email fpalm...

View article titled, Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors

Articles

A role for PPARα in the control of SREBP activity and lipid synthesis in the liver

Brian L. Knight, Abdel Hebbachi, David Hauton, Anna-Marie Brown, David Wiggins, Dilip D. Patel, Geoffrey F. Gibbons

Biochem J (2005) 389 (2): 413–421.

https://doi.org/10.1042/BJ20041896

Published: 05 July 2005

..., we conducted gene expression analysis using microarrays containing probes for most of the known mouse genes. Throughout, verification of the specificity of PPARα in mediating effects resulting from WY 14,634 was achieved by carrying out identical experiments in PPARα-knockout mice. PPARα...

View article titled, A role for PPARα in the control of SREBP activity and lipid synthesis in the liver

Articles

Up-regulation of phospholipid hydroperoxide glutathione peroxidase in rat casein-induced polymorphonuclear neutrophils

Hiroyuki Hattori, Hirotaka Imai, Akiharu Hanamoto, Kazuhisa Furuhama, Yasuhito Nakagawa

Biochem J (2005) 389 (2): 279–287.

https://doi.org/10.1042/BJ20050006

Published: 05 July 2005

... ]. Accordingly, the antioxidant enzymes may play a key role in the prevention of oxidative damage at an inflammation site. gene expression growth-regulated oncogene inflammation peroxide tone phospholipid hydroperoxide glutathione peroxidase polymorphonuclear leucocyte On the other hand...

View article titled, Up-regulation of phospholipid hydroperoxide glutathione peroxidase in rat casein-induced polymorphonuclear neutrophils

Articles

Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others?

Katarzyna JARONCZYK, Jon B. CARMICHAEL, Tom C. HOBMAN

Biochem J (2005) 387 (3): 561–571.

https://doi.org/10.1042/BJ20041822

Published: 26 April 2005

..., London 2005 Dicer gene expression gene silencing PAZ Piwi domain protein (PPD protein) RNA-induced silencing complex (RISC) RNA interference (RNAi) 1 These authors contributed equally to this work. In vertebrates, PPD proteins appear to be important for regulating...

View article titled, Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others?

Articles

Is the regulation of galactose 1-phosphate tuned against gene expression noise?

Pedro de ATAURI, David ORRELL, Stephen RAMSEY, Hamid BOLOURI

Biochem J (2005) 387 (1): 77–84.

https://doi.org/10.1042/BJ20041001

Published: 22 March 2005

... properties of the GT encoded by GAL7 . The Biochemical Society, London 2005 galactose-1-phosphate uridylyltransferase galactose uptake gene expression metabolic pathway noise transmission Saccharomyces cerevisiae The cellular translation machinery allows the synthesis of large...

View article titled, Is the regulation of galactose 1-phosphate tuned against gene expression noise?

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only