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Articles

Folate deficiency promotes differentiation of vascular smooth muscle cells without affecting the methylation status of regulated genes

Andreas F. Kolb, Linda Petrie, Claus D. Mayer, Lynn Pirie, Susan J. Duthie

Biochem J (2019) 476 (19): 2769–2795.

https://doi.org/10.1042/BCJ20190275

Published: 11 October 2019

... changes observed in response to folate deficiency. Folate deficiency only has a marginal effect on global DNA methylation. DNA methylation of CpG islands associated with genes regulated by folate deficiency remains unaffected. This supports our earlier findings in a mouse model system which also did...

View article titled, Folate deficiency promotes differentiation of vascular smooth muscle cells without affecting the methylation status of regulated genes

Includes: Supplementary data

Articles

Dual phosphorylation in response regulator protein PrrA is crucial for intracellular survival of mycobacteria consequent upon transcriptional activation

Alok K. Mishra, Shivraj M. Yabaji, Rikesh K. Dubey, Ekta Dhamija, Kishore K. Srivastava

Biochem J (2017) 474 (24): 4119–4136.

https://doi.org/10.1042/BCJ20170596

Published: 06 December 2017

...). Published by Portland Press Limited on behalf of the Biochemical Society 2017 bacterial pathogenesis gene regulation histidine kinase mycobacteria protein phosphorylation Mycobacterium tuberculosis ( Mtb ) is a successful intracellular pathogen and continues to be one of the leading...

View article titled, Dual phosphorylation in response regulator protein PrrA is crucial for intracellular survival of mycobacteria consequent upon transcriptional activation

Includes: Supplementary data

Articles

TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors

Christian Bindesbøll, Susanna Tan, Debbie Bott, Tiffany Cho, Laura Tamblyn, Laura MacPherson, Line Grønning-Wang, Hilde Irene Nebb, Jason Matthews

Biochem J (2016) 473 (7): 899–910.

https://doi.org/10.1042/BJ20151077

Published: 29 March 2016

..., a small but powerful family of poly-ADP-ribose polymerases Front. Biosci. 2008 13 3046 3082 10.2741/2909 17981777 14 Kraus W.L. Hottiger M.O. PARP-1 and gene regulation: Progress and puzzles Mol. Aspects Med. 2013 14 1109 1123 10.1016/j.mam.2013.01.005 15 Meyer...

View article titled, TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors

Includes: Supplementary data

Articles

Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells

Xin-rui Lv, Bin Zheng, Shu-ya Li, Ai-li Han, Chang Wang, Jian-hong Shi, Xin-hua Zhang, Yan Liu, Yong-hui Li, Jin-kun Wen

Biochem J (2013) 456 (1): 35–46.

https://doi.org/10.1042/BJ20130418

Published: 24 October 2013

... the expression of active peptides in the cardiovascular system. Am80 promotes the interaction of RARα (retinoic acid receptor α) with KLF5 (Krüppel-like factor 5) and Sp1 (stimulating protein-1) prebound to the apelin promoter to enhance apelin gene transcription. apelin gene regulation nuclear receptor...

View article titled, Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells

Includes: Supplementary data

Articles

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

Laura Novellasdemunt, Laurent Bultot, Anna Manzano, Francesc Ventura, Jose Luis Rosa, Didier Vertommen, Mark H. Rider, Àurea Navarro-Sabate, Ramon Bartrons

Biochem J (2013) 452 (3): 531–543.

https://doi.org/10.1042/BJ20121886

Published: 31 May 2013

... affecting PFKFB3 transcriptional regulation and kinase activation by protein phosphorylation, resulting in an increase in Fru-2,6-P 2 concentration and stimulation of glycolysis in cancer cells. © The Authors Journal compilation © 2013 Biochemical Society 2013 gene regulation glycolysis metabolism...

View article titled, PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

Includes: Supplementary data

Articles

Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ

Jewell N. Walters, Justin S. Bickford, Kimberly J. Newsom, Dawn E. Beachy, Sarah J. Barilovits, John-David Herlihy, Harry S. Nick

Biochem J (2012) 443 (2): 561–571.

https://doi.org/10.1042/BJ20111801

Published: 27 March 2012

... immunoprecipitation) analysis demonstrated constitutive Egr-1 binding to the promoter and induced RNA polymerase II and C/EBPβ binding to the promoter and enhancer respectively. Knockout/knockdown studies established a functional role for C/EBPβ in mPGES-1 gene regulation and the documented interaction between Egr-1...

View article titled, Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ

Includes: Supplementary data

Articles

Involvement of PGE 2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages

Manuel D. Díaz-Muñoz, Inés C. Osma-García, Manuel Fresno, Miguel A. Iñiguez

Biochem J (2012) 443 (2): 451–461.

https://doi.org/10.1042/BJ20111052

Published: 27 March 2012

...-prostanoid (EP) receptor gene regulation inflammation lipid mediator microsomal prostaglandin E synthase 1 (mPGES-1) PGs (prostaglandins) and TXs (thromboxanes) are important lipid mediators involved in physiological and pathological processes. These agents are generated from the conversion of AA...

View article titled, Involvement of PGE 2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages

Articles

Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression

Ning Liu, Zhanyang Yu, Shuanglin Xiang, Song Zhao, Anna Tjärnlund-Wolf, Changhong Xing, Jian Zhang, Xiaoying Wang

Biochem J (2012) 443 (1): 153–164.

https://doi.org/10.1042/BJ20111856

Published: 14 March 2012

... to the manufacturer's protocol. Briefly, RT-PCR was performed on an ABI 7500 detection system (Applied Biosystems). Data were analysed according to the standard comparative threshold cycle method. Melting curves for each PCR were generated to ensure the purity of the amplification products. gene regulation...

View article titled, Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression

Articles

Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells

Laura Novellasdemunt, Mercè Obach, Lluís Millán-Ariño, Anna Manzano, Francesc Ventura, Jose Luis Rosa, Albert Jordan, Àurea Navarro-Sabate, Ramon Bartrons

Biochem J (2012) 442 (2): 345–356.

https://doi.org/10.1042/BJ20111418

Published: 13 February 2012

... in response to norgestrel. Direct binding of PR to the PRE box (−3490 nt) was confirmed by ChIP (chromatin immunoprecipiation) experiments. A dual mechanism affecting PFKFB3 protein and gene regulation operates in order to assure glycolysis in breast cancer cells. An immediate early response through the ERK...

View article titled, Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells

Articles

Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2

Henna-Kaisa Jyrkkänen, Suvi Kuosmanen, Merja Heinäniemi, Heidi Laitinen, Emilia Kansanen, Eero Mella-Aho, Hanna Leinonen, Seppo Ylä-Herttuala, Anna-Liisa Levonen

Biochem J (2011) 440 (2): 167–174.

https://doi.org/10.1042/BJ20110526

Published: 14 November 2011

... and that induction of BACH1 by Nrf2 may serve as a feedback-inhibitory mechanism for ARE-mediated gene regulation. © The Authors Journal compilation © 2011 Biochemical Society 2011 antioxidant-response element (ARE) BTB and CNC homology 1 (BACH1) gene expression gene regulation nuclear factor-erythroid 2...

View article titled, Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2

Includes: Supplementary data

Articles

The mitochondrial citrate carrier: a new player in inflammation

Vittoria Infantino, Paolo Convertini, Liana Cucci, Maria Antonietta Panaro, Maria Antonietta Di Noia, Rosa Calvello, Ferdinando Palmieri, Vito Iacobazzi

Biochem J (2011) 438 (3): 433–436.

https://doi.org/10.1042/BJ20111275

Published: 26 August 2011

...) Substrate (Millipore). citrate carrier (CIC) gene regulation immune cell nitric oxide (NO) prostaglandin E 2 reactive oxygen species (ROS) Inflammation is an immune response to infection, tissue injury and other noxious insults [ 1 ]. It is characterized by the production...

View article titled, The mitochondrial citrate carrier: a new player in inflammation

Includes: Supplementary data

Articles

Escherichia coli glycogen genes are organized in a single glgBXCAP transcriptional unit possessing an alternative suboperonic promoter within glgC that directs glgAP expression

Manuel Montero, Goizeder Almagro, Gustavo Eydallin, Alejandro M. Viale, Francisco J. Muñoz, Abdellatif Bahaji, Jun Li, Mehdi Rahimpour, Edurne Baroja-Fernández, Javier Pozueta-Romero

Biochem J (2011) 433 (1): 107–117.

https://doi.org/10.1042/BJ20101186

Published: 15 December 2010

... was measured by the Bradford method using a Bio-Rad prepared reagent. Escherichia coli gene regulation glg operon glycogen metabolism PhoP-PhoQ regulatory system suboperonic promoter Glycogen is a branched homopolysaccharide of α-1,4-linked glucose subunits with α-1,6-linkages...

View article titled, Escherichia coli glycogen genes are organized in a single glgBXCAP transcriptional unit possessing an alternative suboperonic promoter within glgC that directs glgAP expression

Includes: Supplementary data

Articles

Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3′ untranslated region

Marc A. Thomas, Darren M. Preece, Jacqueline M. Bentel

Biochem J (2010) 425 (3): 575–583.

https://doi.org/10.1042/BJ20091109

Published: 15 January 2010

... 2010 Biochemical Society 2010 androgen receptor gene regulation NKX3.1 prostate cancer 3′-untranslated region (3′UTR) Androgens are essential regulators of the formation, normal growth and differentiated function of male urogenital structures, including the prostate gland [ 1...

View article titled, Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3′ untranslated region

Articles

Regulation of mRNA cap methylation

Victoria H. Cowling

Biochem J (2010) 425 (2): 295–302.

https://doi.org/10.1042/BJ20091352

Published: 23 December 2009

... in structure and mode of action from yeast to metazoa, whereas the RNA triphosphatases are quite different in structure and mode of action in yeast and metazoa [ 1 ]. gene regulation mRNA cap methylation translation transcription Eukaryotic mRNA is modified by the addition of the 7...

View article titled, Regulation of mRNA cap methylation

Articles

Nuclear factor κB (NF-κB) activation primes cells to a pro-inflammatory polarized response to a Toll-like receptor 7 (TLR7) agonist

Jongdae Lee, Masaaki Hayashi, Jeng-Fan Lo, Colleen Fearns, Wen-Ming Chu, Yunping Luo, Rong Xiang, Tsung-Hsien Chuang

Biochem J (2009) 421 (2): 301–310.

https://doi.org/10.1042/BJ20090013

Published: 26 June 2009

... [email protected] ). 6 1 2009 1 5 2009 8 5 2009 8 5 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cell activation gene regulation inflammation interferon regulatory factor nuclear factor-κB (NF-κB) Toll-like receptor (TLR) TLRs (Toll...

View article titled, Nuclear factor κB (NF-κB) activation primes cells to a pro-inflammatory polarized response to a Toll-like receptor 7 (TLR7) agonist

Includes: Supplementary data

Articles

Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis

Sven Horke, Ines Witte, Petra Wilgenbus, Sebastian Altenhöfer, Maximilian Krüger, Huige Li, Ulrich Förstermann

Biochem J (2008) 416 (3): 395–405.

https://doi.org/10.1042/BJ20080775

Published: 26 November 2008

... endoplasmic reticulum stress gene regulation paraoxonase Upon synthesis, all proteins destined for transmembrane insertion or secretion translocate to the ER (endoplasmic reticulum). The ER is the site of protein amino-glycosylation, disulfide bond formation and proper folding of nascent proteins...

View article titled, Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis

Articles

Modulation of hepatocyte nuclear factor-4α function by the peroxisome-proliferator-activated receptor-γ co-activator-1α in the acute-phase response

Zhongyan Wang, Peter A. Burke

Biochem J (2008) 415 (2): 289–296.

https://doi.org/10.1042/BJ20080355

Published: 25 September 2008

... that important physiological control of gene-regulatory systems are not solely the effect of transcription factors. Co-activator proteins also participate in gene regulation. Indeed, it has been shown that HNF-4α, like other nuclear receptors, provokes gene activation in concert with transcription co-activators...

View article titled, Modulation of hepatocyte nuclear factor-4α function by the peroxisome-proliferator-activated receptor-γ co-activator-1α in the acute-phase response

Articles

Association of human DNA helicase RecQ5β with RNA polymerase II and its possible role in transcription

Keiichi Izumikawa, Mitsuaki Yanagida, Toshiya Hayano, Hiroyuki Tachikawa, Wataru Komatsu, Akira Shimamoto, Kazunobu Futami, Yasuhiro Furuichi, Takashi Shinkawa, Yoshio Yamauchi, Toshiaki Isobe, Nobuhiro Takahashi

Biochem J (2008) 413 (3): 505–516.

https://doi.org/10.1042/BJ20071392

Published: 15 July 2008

... compilation © 2008 Biochemical Society 2008 functional proteomics gene regulation protein–protein interaction RecQ5β RNA polymerase II (RNAP II) transcription The proteins belonging to the RecQ family are distributed among a wide range of species, from unicellular organisms...

View article titled, Association of human DNA helicase RecQ5β with RNA polymerase II and its possible role in transcription

Includes: Supplementary data

Articles

PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate

Abdenour Soufi, Padma-Sheela Jayaraman

Biochem J (2008) 412 (3): 399–413.

https://doi.org/10.1042/BJ20080035

Published: 28 May 2008

... interface. Here we will review the current literature on PRH and discuss the complex web of interactions centred on this multifunctional protein. Table 1 PRH target genes Gene Regulation Model Method References Goosecoid Repressed Xenopus embryos Ectopic expression [ 34...

View article titled, PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate

Articles

Human heart LIM protein activates atrial-natriuretic-factor gene expression by interacting with the cardiac-restricted transcription factor Nkx2.5

Bin Zheng, Mei Han, Jin-kun Wen, Rui Zhang

Biochem J (2008) 409 (3): 683–690.

https://doi.org/10.1042/BJ20070977

Published: 15 January 2008

... should be addressed (email [email protected] ). 23 7 2007 1 10 2007 11 10 2007 11 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 atrial natriuretic factor (ANF) cardiac-restricted transcription factor (Nkx2.5) gene regulation human heart LIM...

View article titled, Human heart LIM protein activates atrial-natriuretic-factor gene expression by interacting with the cardiac-restricted transcription factor Nkx2.5

Articles

Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse

Elizabeth A. Shephard, Pritpal Chandan, Milena Stevanovic-Walker, Mina Edwards, Ian R. Phillips

Biochem J (2007) 406 (3): 491–499.

https://doi.org/10.1042/BJ20070523

Published: 29 August 2007

...-containing mono-oxygenase 1 (FMO1) gene regulation long-interspersed nuclear element (LINE) promoter retrotransposon © The Authors Journal compilation © 2007 Biochemical Society 2007 Mammalian FMOs (flavin-containing mono-oxygenases; EC 1.14.13.8) are microsomal enzymes that catalyse...

View article titled, Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse

Articles

The β-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6

Benoit R. Gauthier, Yvan Gosmain, Aline Mamin, Jacques Philippe

Biochem J (2007) 403 (3): 593–601.

https://doi.org/10.1042/BJ20070053

Published: 12 April 2007

..., The Biochemical Society, London 2007 gene regulation glucagon Nkx6.1 Pancreas development is orchestrated by the sequential activation of key transcription factors that will dictate the fate of progenitor cells towards exocrine tissue or endocrine entities comprising insulin (β)-, glucagon (α...

View article titled, The β-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6

Articles

Importin α 1 is involved in the nuclear localization of Zac1 and the induction of p21 WAF1/CIP1 by Zac1

Shih-Ming Huang, Sheng-Ping Huang, Sung-Ling Wang, Pei-Yao Liu

Biochem J (2007) 402 (2): 359–366.

https://doi.org/10.1042/BJ20061295

Published: 12 February 2007

... the appropriate PCR fragments into the EcoRI/XhoI sites of pGEX-4T1 (GE Healthcare). 24 8 2006 6 11 2006 16 11 2006 16 11 2006 The Biochemical Society, London 2007 gene regulation importin α 1 nuclear localization p21 zinc finger zinc-finger protein which regulates...

View article titled, Importin α 1 is involved in the nuclear localization of Zac1 and the induction of p21 WAF1/CIP1 by Zac1

Articles

Regulation of ceruloplasmin in human hepatic cells by redox active copper: identification of a novel AP-1 site in the ceruloplasmin gene

Dola Das, Nisha Tapryal, Shyamal K. Goswami, Paul L. Fox, Chinmay K. Mukhopadhyay

Biochem J (2007) 402 (1): 135–141.

https://doi.org/10.1042/BJ20060963

Published: 25 January 2007

... To whom correspondence should be addressed (email [email protected] ). 26 6 2006 7 9 2006 11 10 2006 11 10 2006 The Biochemical Society, London 2007 activator protein-1 (AP-1) ceruloplasmin copper gene regulation luciferase transcription Cp...

View article titled, Regulation of ceruloplasmin in human hepatic cells by redox active copper: identification of a novel AP-1 site in the ceruloplasmin gene

Articles

Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1

Anna L. Remoli, Giulia Marsili, Edvige Perrotti, Eleonora Gallerani, Ramona Ilari, Filomena Nappi, Aurelio Cafaro, Barbara Ensoli, Riccardo Gavioli, Angela Battistini

Biochem J (2006) 396 (2): 371–380.

https://doi.org/10.1042/BJ20051570

Published: 15 May 2006

... modulates CTL (cytotoxic T-lymphocyte) epitope hierarchy by modifying the catalytic subunit composition of immunoproteasomes [ 7 ]. gene regulation HIV-1 infection interferon-regulatory factor-1 (IRF-1) signal transducer and activator of transcription 1 (STAT1) Tat transcription factor...

View article titled, Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1

Articles

Functional properties and differential mode of regulation of the nitrate transporter from a plant symbiotic ascomycete

Barbara Montanini, Arturo R. Viscomi, Angelo Bolchi, Yusé Martin, José M. Siverio, Raffaella Balestrini, Paola Bonfante, Simone Ottonello

Biochem J (2006) 394 (1): 125–134.

https://doi.org/10.1042/BJ20051199

Published: 27 January 2006

... in this paper have been submitted to the GenBank®, DDBJ and EMBL databases under the accession numbers AF462038 (TbNrt2 coding region) and AY786418 (TbNrt2 upstream non-coding region). 25 7 2005 12 9 2005 5 10 2005 5 10 2005 The Biochemical Society, London 2006 gene...

View article titled, Functional properties and differential mode of regulation of the nitrate transporter from a plant symbiotic ascomycete

Articles

The family feud: turning off Sp1 by Sp1-like KLF proteins

Gwen Lomberk, Raul Urrutia

Biochem J (2005) 392 (1): 1–11.

https://doi.org/10.1042/BJ20051234

Published: 08 November 2005

... 8 2005 The Biochemical Society, London 2005 co-repressor gene regulation Krüppel-like factor (KLF) Sp1 transcription factor zinc-finger domain Sp1, the founding member of the family of proteins described in the present review, represents the most characterized...

View article titled, The family feud: turning off Sp1 by Sp1-like KLF proteins

Articles

Characterization of cis -regulatory elements of the vascular endothelial growth inhibitor gene promoter

Qingli XIAO, Chung Y. HSU, Hong CHEN, Xiucui MA, Jan XU, Jin-Moo LEE

Biochem J (2005) 388 (3): 913–920.

https://doi.org/10.1042/BJ20041739

Published: 07 June 2005

... role in the regulation of VEGI expression. 13 10 2004 20 1 2005 10 2 2005 10 2 2005 The Biochemical Society, London 2005 cis -regulatory element electrophoretic mobility-shift assay gene promoter gene regulation transcription factor vascular endothelial growth...

View article titled, Characterization of cis -regulatory elements of the vascular endothelial growth inhibitor gene promoter

Articles

Sp3 is involved in the regulation of SOCS3 gene expression

Christian EHLTING, Dieter HÄUSSINGER, Johannes G. BODE

Biochem J (2005) 387 (3): 737–745.

https://doi.org/10.1042/BJ20041101

Published: 26 April 2005

... that the acetylation of this lysine residue of Sp3 is important for the enhancing effect of Sp3 on SOCS3 expression. 28 6 2004 10 11 2004 23 11 2004 23 11 2004 The Biochemical Society, London 2005 cytokine gene regulation signal transduction SOCS3 gene Sp3 transcription factor...

View article titled, Sp3 is involved in the regulation of SOCS3 gene expression

Articles

Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins

Artit JINAWATH, Satoshi MIYAKE, Yuka YANAGISAWA, Yoshimitsu AKIYAMA, Yasuhito YUASA

Biochem J (2005) 385 (2): 557–564.

https://doi.org/10.1042/BJ20040684

Published: 07 January 2005

..., Aoba-ku, Sendai 980-8575, Japan. 2 To whom correspondence should be addressed (email [email protected] ). 27 4 2004 5 8 2004 14 9 2004 14 9 2004 The Biochemical Society, London 2005 DNA methyltransferase (DNMT) gene regulation mithramycin A specificity...

View article titled, Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins

Articles

IκBα (inhibitory κBα) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression

Kelley K. KININGHAM, Chotiros DAOSUKHO, Daret K. ST. CLAIR

Biochem J (2004) 384 (3): 543–549.

https://doi.org/10.1042/BJ20040714

Published: 07 December 2004

... pharmacological approach to up-regulate MnSOD. The Biochemical Society, London 2004 1 To whom correspondence should be addressed (email [email protected] ). 29 4 2004 20 8 2004 26 8 2004 26 8 2004 cycloheximide gene regulation manganese superoxide dismutase...

View article titled, IκBα (inhibitory κBα) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression

Articles

The NRF-1/α-PAL transcription factor regulates human E2F6 promoter activity

Zoulika KHERROUCHE, Yvan DE LAUNOIT, Didier MONTE

Biochem J (2004) 383 (3): 529–536.

https://doi.org/10.1042/BJ20040935

Published: 26 October 2004

..., suggesting a broad role for NRF-1 in the transcriptional modulation of genes implicated in various cellular functions. chromatin immunoprecipitation (ChIP) E2F gene gene regulation NRF-1/α-PAL (nuclear respiratory factor-1/α-palindrome-binding protein) promoter analysis In the present study...

View article titled, The NRF-1/α-PAL transcription factor regulates human E2F6 promoter activity

Articles

Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

Philip BUFLER, Fabia GAMBONI-ROBERTSON, Tania AZAM, Soo-Hyun KIM, Charles A. DINARELLO

Biochem J (2004) 381 (2): 503–510.

https://doi.org/10.1042/BJ20040217

Published: 06 July 2004

..., U.S.A.). 9 2 2004 25 3 2004 26 3 2004 26 3 2004 The Biochemical Society, London 2004 cytokine gene regulation interleukin 1 lipopolysaccharide monocyte macrophage The IL-1 (interleukin 1) family is an expanding family of cytokines sharing a similar all β...

View article titled, Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

Articles

Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor

Peng WANG, Ji ZHANG, Hong BIAN, Ping WU, Reshma KUVELKAR, Ted T. KUNG, Yvette CRAWLEY, Robert W. EGAN, M. Motasim BILLAH

Biochem J (2004) 380 (2): 425–433.

https://doi.org/10.1042/bj20031896

Published: 01 June 2004

... cytokine gene regulation T-lymphocyte neuraminidase sialidase Abbreviations used: BAL, bronchoalveolar lavage; G D1a , NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ1-cer; G D1b , Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ1-cer; G M3 , NeuAcα2-3Galβ1-4Glcβ1-cer; G3PDH, glyceraldehyde-3...

View article titled, Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor

Articles

Cloning and characterization of the human beta2-glycoprotein I (beta2-GPI) gene promoter: roles of the atypical TATA box and hepatic nuclear factor-1alpha in regulating beta2-GPI promoter activity

Hsueh-Hsiao WANG, An-Na CHIANG

Biochem J (2004) 380 (2): 455–463.

https://doi.org/10.1042/bj20031610

Published: 01 June 2004

... of HNF-1 enhanced the endogenous 2-GPI expression. These results sug- gest that the atypical TATA box and HNF-1 cis-element are critical for 2-GPI transcription and HNF-1 may play an important role in cell-specific regulation of 2-GPI gene expression. Key words: gene regulation, 2-glycoprotein I...

View article titled, Cloning and characterization of the human beta2-glycoprotein I (beta2-GPI) gene promoter: roles of the atypical TATA box and hepatic nuclear factor-1alpha in regulating beta2-GPI promoter activity

Articles

Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene

Dorota ŚCIEGLIŃSKA, Natallia VYDRA, Zdzisław KRAWCZYK, Wiesława WIDŁAK

Biochem J (2004) 379 (3): 739–747.

https://doi.org/10.1042/bj20031842

Published: 01 May 2004

... (octamer) sequence localized directly downstream of the T1 site. 1 To whom correspondence should be addressed (e-mail [email protected] ). 1 12 2003 29 1 2004 6 2 2004 6 2 2004 The Biochemical Society, London ©2004 2004 gene regulation heat shock protein Oct...

View article titled, Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene

Articles

pH-dependent autocleavage of lambda repressor occurs in the operator-bound form: characterization of lambda repressor autocleavage

Kaushik GHOSH, Atasi PAL, Rajagopal CHATTOPADHYAYA

Biochem J (2004) 379 (2): 325–330.

https://doi.org/10.1042/bj20031834

Published: 15 April 2004

... RecA- mediated cleavage is absent. Key words: repressor autocleavage, covalent modification by in- hibitor, gene regulation, operator-binding and repressor function, self-proteolysis, trans-cleavage. INTRODUCTION At the heart of the gene regulatory system of the double-stranded DNA bacteriophage...

View article titled, pH-dependent autocleavage of lambda repressor occurs in the operator-bound form: characterization of lambda repressor autocleavage

Articles

Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms

Xiangshan ZHAO, Lixia GAN, Haiyun PAN, Donghui KAN, Michael MAJESKI, Stephen A. ADAM, Terry G. UNTERMAN

Biochem J (2004) 378 (3): 839–849.

https://doi.org/10.1042/bj20031450

Published: 15 March 2004

... Society, London ©2004 2004 Forkhead 14-3-3 protein gene regulation growth factor insulin transcription Abbreviations used: DBD, DNA-binding domain; NES, nuclear export sequence; GFP, green fluorescent protein; PKB, protein kinase B; NLS, nuclear localization signal; CK1, casein kinase...

View article titled, Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms

Articles

Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP

Richard WHALEN, Susan H. VOSS, Thomas D. BOYER

Biochem J (2004) 377 (3): 763–768.

https://doi.org/10.1042/bj20031256

Published: 01 February 2004

... to increased IL6DEX-NP binding. IL6DEX-NP appears to be an important negative regulator of gene expression in vitro and in vivo . cytokine gene regulation sepsis transcription transcription factor Abbreviations used: DEX, dexamethasone; EMSA, electrophoretic mobility-shift assay; GST...

View article titled, Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP

Articles

Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor α/thyroid receptor β heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor β and upstream stimulatory factor 2a

Eudoxia HATZIVASSILIOU, George KOUKOS, Agnes RIBEIRO, Vassilis ZANNIS, Dimitris KARDASSIS

Biochem J (2003) 376 (2): 423–431.

https://doi.org/10.1042/bj20030549

Published: 01 December 2003

... The Biochemical Society, London ©2003 2003 apolipoprotein atherosclerosis gene regulation hormone nuclear receptor thyroid hormone-responsive element transcriptional synergism Abbreviations used: apoA-II, apolipoprotein A-II; ARP-1, apoA-I regulatory protein 1; CAT, chloramphenicol...

View article titled, Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor α/thyroid receptor β heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor β and upstream stimulatory factor 2a

Articles

Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

Tatsuo FURUYAMA, Kazuko KITAYAMA, Hitoshi YAMASHITA, Nozomu MORI

Biochem J (2003) 375 (2): 365–371.

https://doi.org/10.1042/bj20030022

Published: 15 October 2003

... 2003 forkhead transcription factor FOXO gene regulation pyruvate dehydrogenase kinase 4 (PDK4) skeletal muscle starvation Abbreviations used: CR, caloric restriction; DBE, DAF-16 family binding element; DMEM, Dulbecco's modified Eagle's medium; FKHR, forkhead homologue...

View article titled, Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

Articles

The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb

Vilborg MATRE, Per I. HØVRING, Åse-Karine FJELDHEIM, Lars HELGELAND, Christophe ORVAIN, Kristin B. ANDERSSON, Kaare M. GAUTVIK, Odd S. GABRIELSEN

Biochem J (2003) 372 (3): 851–859.

https://doi.org/10.1042/bj20030057

Published: 15 June 2003

...-Myb binding site, gene regulation, promoter analy- sis, thymus, thyrotropin-releasing hormone (TRH), thyrotropin- releasing hormone receptor (TRHR). INTRODUCTION Thyrotropin-releasing hormone (TRH) is a tripeptide (pGlu- His-Pro-NH2; where pGlu stands for pyroglutamic acid) that is released from...

View article titled, The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb

Articles

Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids

Dimitris KARDASSIS, Anastasia ROUSSOU, Paraskevi PAPAKOSTA, Konstantinos BOULIAS, Iannis TALIANIDIS, Vassilis I. ZANNIS

Biochem J (2003) 372 (2): 291–304.

https://doi.org/10.1042/bj20021532

Published: 01 June 2003

... apolipoprotein C-II (apoC-II) bile acids gene regulation hepatic control region 1 (HCR-1) hypertriglyceridaemia Abbreviations used: apoC-I (etc.), apolipoprotein C-I (etc.); apoC-I´ apoC-I pseudogene; ARP-1, apoA-I regulatory protein 1; ARP-PO, acidic ribosomal phosphoprotein; CA, cholic acid; CAT...

View article titled, Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II <span class="search-highlight">gene</span> <span class="search-highlight">regulation</span> by bile acids and retinoids

Articles

Transcriptional regulation of the human Sp1 gene promoter by the specificity protein (Sp) family members nuclear factor Y (NF-Y) and E2F

Marta NICOLÁS, Vèronique NOÉ, Carlos J. CIUDAD

Biochem J (2003) 371 (2): 265–275.

https://doi.org/10.1042/bj20021166

Published: 15 April 2003

... of Sp1, Sp3, E2F and NF-Y proteins in the cell. 1 To whom correspondence should be addressed (e-mail [email protected] ). 25 7 2002 5 12 2002 3 1 2003 3 1 2003 The Biochemical Society, London ©2003 2003 E2F gene promoter gene regulation nuclear factor Y...

View article titled, Transcriptional regulation of the human Sp1 gene promoter by the specificity protein (Sp) family members nuclear factor Y (NF-Y) and E2F

Articles

Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene

Enrique SALERO, Cecilio GIMÉNEZ, Francisco ZAFRA

Biochem J (2003) 370 (3): 979–986.

https://doi.org/10.1042/bj20021142

Published: 15 March 2003

... should be addressed (e-mail [email protected] ). 19 7 2002 15 11 2002 25 11 2002 15 3 2003 The Biochemical Society, London ©2003 2003 Alzheimer's disease apolipoprotein E E-box gene regulation nervous system upstream regulatory factor (USF) Abbreviations...

View article titled, Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene

Articles

Genomic organization and transcriptional analysis of the human l-glutaminase gene

Cristina PÉREZ-GÓMEZ, José M. MATÉS, Pedro M. GÓMEZ-FABRE, Antonio del CASTILLO-OLIVARES, Francisco J. ALONSO, Javier MÁRQUEZ

Biochem J (2003) 370 (3): 771–784.

https://doi.org/10.1042/bj20021445

Published: 15 March 2003

... distal element for transcriptional regulation of the hLGA gene. Key words: breast cancer cells, gene regulation, glutamine, hepatoma cancer cells, promoter analysis. has been shown to be expressed also in rat kidney and pig renal cells [9]. The rat (r)KGA promoter has been characterized; it lacks a TATA...

View article titled, Genomic organization and transcriptional analysis of the human l-glutaminase gene

Articles

Characterization of the human topoisomerase IIβ (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites

Chun-Nam LOK, Alexander J. LANG, Shelagh E.L. MIRSKI, Susan P.C. COLE

Biochem J (2002) 368 (3): 741–751.

https://doi.org/10.1042/bj20020791

Published: 15 December 2002

... 8 2002 28 8 2002 The Biochemical Society, London ©2002 2002 gene regulation promoter analysis Abbreviations used: DOTAP/DOPE, N -[1-(2,3-dioleoyloxy)propyl]- N , N , N -trimethylammonium methylsulphate/dioleoyl phosphatidylethanolamine; GMSA, gel mobility-shift assay...

View article titled, Characterization of the human topoisomerase IIβ (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites

Articles

The antioxidant (−)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression

Anping CHEN, Li ZHANG, Jianye XU, Jun TANG

Biochem J (2002) 368 (3): 695–704.

https://doi.org/10.1042/bj20020894

Published: 15 December 2002

... 9 2002 The Biochemical Society, London ©2002 2002 alcohol apoptosis fibrogenesis gene regulation green tea extract Abbreviations used: BrdU, bromodeoxyuridine; DMEM, Dulbecco's modified Eagle's medium; ECM, extracellular matrix; EGCG, (—)-epigallocatechin-3-gallate; EMSA...

View article titled, The antioxidant (−)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression

Articles

Co-operation of the transcription factor hepatocyte nuclear factor-4 with Sp1 or Sp3 leads to transcriptional activation of the human haem oxygenase-1 gene promoter in a hepatoma cell line

Shigeru TAKAHASHI, Naomi MATSUURA, Takako KUROKAWA, Yuji TAKAHASHI, Takashi MIURA

Biochem J (2002) 367 (3): 641–652.

https://doi.org/10.1042/bj20020819

Published: 01 November 2002

... 7 2002 22 7 2002 The Biochemical Society, London ©2002 2002 enhancer GC box gene regulation HepG2 cells Abbreviations used: AP-1, activator protein-1; ARP, apolipoprotein regulatory protein; CBP, CREB ('cAMP-response-element-binding protein') binding protein; C/EBP...

View article titled, Co-operation of the transcription factor hepatocyte nuclear factor-4 with Sp1 or Sp3 leads to transcriptional activation of the human haem oxygenase-1 gene promoter in a hepatoma cell line

Articles

Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor κB

Zhiyuan YU, Wenzheng ZHANG, Bruce C. KONE

Biochem J (2002) 367 (1): 97–105.

https://doi.org/10.1042/bj20020588

Published: 01 October 2002

.... Key words: gene regulation, mesangial cell, promoter. Various signalling pathways and inducible transcription factors, including cAMP [5], c-Jun N-terminal kinase and p38 mitrogen- activated protein kinase [7], cAMP-response-element-binding protein (CREB) [5], CCAAT}enhancer-binding protein b [5...

View article titled, Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor κB

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