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Keywords: gene regulation
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Articles
Biochem J (2019) 476 (19): 2769–2795.
Published: 11 October 2019
... changes observed in response to folate deficiency. Folate deficiency only has a marginal effect on global DNA methylation. DNA methylation of CpG islands associated with genes regulated by folate deficiency remains unaffected. This supports our earlier findings in a mouse model system which also did not...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (24): 4119–4136.
Published: 06 December 2017
... gene regulation histidine kinase mycobacteria protein phosphorylation Mycobacterium tuberculosis ( Mtb ) is a successful intracellular pathogen and continues to be one of the leading causes of mortality worldwide [ 1 , 2 ]. Despite extensive tuberculosis management programs, it still...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (7): 899–910.
Published: 29 March 2016
... (LXRα) and LXRβ activity. The ability of TIPARP to increase LXR activity was also reversed by macrodomain 1 (MACROD1), suggesting that reversible ADP-ribosylation regulates LXR activity. ADP-ribosylation gene regulation liver X receptor nuclear receptor post-translational modification 2 3 7...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (1): 35–46.
Published: 24 October 2013
... retinoids regulate the expression of active peptides in the cardiovascular system. Am80 promotes the interaction of RARα (retinoic acid receptor α) with KLF5 (Krüppel-like factor 5) and Sp1 (stimulating protein-1) prebound to the apelin promoter to enhance apelin gene transcription. apelin gene...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (3): 531–543.
Published: 31 May 2013
... (email aureanavarro@ub.edu ). 19 12 2012 22 3 2013 2 4 2013 2 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 gene regulation glycolysis metabolism mitogen- activated protein kinase-activated protein kinase 2 (MK2) p38 6-phosphofructo-2...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (2): 561–571.
Published: 27 March 2012
... immunoprecipitation) analysis demonstrated constitutive Egr-1 binding to the promoter and induced RNA polymerase II and C/EBPβ binding to the promoter and enhancer respectively. Knockout/knockdown studies established a functional role for C/EBPβ in mPGES-1 gene regulation and the documented interaction between Egr-1...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (2): 451–461.
Published: 27 March 2012
...@cbm.uam.es ). 14 6 2011 19 12 2011 23 1 2012 23 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cyclo-oxygenase-2 (COX-2) E-prostanoid (EP) receptor gene regulation inflammation lipid mediator microsomal prostaglandin E synthase 1 (mPGES-1...
Articles
Biochem J (2012) 443 (1): 153–164.
Published: 14 March 2012
... authors (email zhangjian@hunnu.edu.cn or wangxi@helix.mgh.harvard.edu ). gene regulation hypoxia mouse neuroglobin promoter transcription factor 18 10 2011 15 12 2011 13 1 2012 13 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 Ngb...
Articles
Biochem J (2012) 442 (2): 345–356.
Published: 13 February 2012
... in response to norgestrel. Direct binding of PR to the PRE box (−3490 nt) was confirmed by ChIP (chromatin immunoprecipiation) experiments. A dual mechanism affecting PFKFB3 protein and gene regulation operates in order to assure glycolysis in breast cancer cells. An immediate early response through...
Articles
Biochem J (2011) 440 (2): 167–174.
Published: 14 November 2011
... gene and that induction of BACH1 by Nrf2 may serve as a feedback-inhibitory mechanism for ARE-mediated gene regulation. HUVECs were transduced with Ad-Nrf2 as described in [ 23 ] and harvested 48 h after transduction for RNA extraction. Confluent HUVECs were used for experiments with SFN, tBHQ or...
Includes: Supplementary data
Articles
Biochem J (2011) 438 (3): 433–436.
Published: 26 August 2011
... Journal compilation © 2011 Biochemical Society 2011 citrate carrier (CIC) gene regulation immune cell nitric oxide (NO) prostaglandin E 2 reactive oxygen species (ROS) Inflammation is an immune response to infection, tissue injury and other noxious insults [ 1 ]. It is characterized by...
Includes: Supplementary data
Articles
Biochem J (2011) 433 (1): 107–117.
Published: 15 December 2010
... javier.pozueta@unavarra.es ). 30 7 2010 14 10 2010 29 10 2010 29 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 Escherichia coli gene regulation glg operon glycogen metabolism PhoP-PhoQ regulatory system suboperonic promoter Glycogen...
Includes: Supplementary data
Articles
Biochem J (2010) 425 (3): 575–583.
Published: 15 January 2010
... © 2010 Biochemical Society 2010 androgen receptor gene regulation NKX3.1 prostate cancer 3′-untranslated region (3′UTR) Androgens are essential regulators of the formation, normal growth and differentiated function of male urogenital structures, including the prostate gland [ 1...
Articles
Biochem J (2010) 425 (2): 295–302.
Published: 23 December 2009
... Commons Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. gene regulation mRNA cap methylation translation transcription...
Articles
Biochem J (2009) 421 (2): 301–310.
Published: 26 June 2009
.... (email tchuang@skcc.org ). 6 1 2009 1 5 2009 8 5 2009 8 5 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cell activation gene regulation inflammation interferon regulatory factor nuclear factor-κB (NF-κB) Toll-like receptor (TLR...
Includes: Supplementary data
Articles
Biochem J (2008) 416 (3): 395–405.
Published: 26 November 2008
... endoplasmic reticulum stress gene regulation paraoxonase Upon synthesis, all proteins destined for transmembrane insertion or secretion translocate to the ER (endoplasmic reticulum). The ER is the site of protein amino-glycosylation, disulfide bond formation and proper folding of nascent proteins...
Articles
Biochem J (2008) 415 (2): 289–296.
Published: 25 September 2008
... increasing PGC-1α levels on HNF-4α-dependent luciferase activity is, in general, positive, but the different degrees of co-activation of individual genes reflects the intrinsic and unique HNF-4α-binding affinity for each individual binding site. acute-phase response (APR) cytokine gene regulation HNF...
Articles
Biochem J (2008) 413 (3): 505–516.
Published: 15 July 2008
... 17 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 functional proteomics gene regulation protein–protein interaction RecQ5β RNA polymerase II (RNAP II) transcription The proteins belonging to the RecQ family are distributed among a wide range of...
Includes: Supplementary data
Articles
Biochem J (2008) 412 (3): 399–413.
Published: 28 May 2008
... cited. development gene regulation haematopoiesis haematopoietically expressed homeobox (Hex) homeodomain oligomerization proline-rich homeodomain (PRH) transcription The PRH (proline-rich homeodomain) protein, also known as the Hex (haematopoietically expressed homeobox) protein...
Articles
Biochem J (2008) 409 (3): 683–690.
Published: 15 January 2008
... should be addressed (email wjk@hebmu.edu.cn ). 23 7 2007 1 10 2007 11 10 2007 11 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 atrial natriuretic factor (ANF) cardiac-restricted transcription factor (Nkx2.5) gene regulation human heart LIM...
Articles
Biochem J (2007) 406 (3): 491–499.
Published: 29 August 2007
... 1 (FMO1) gene regulation long-interspersed nuclear element (LINE) promoter retrotransposon Mammalian FMOs (flavin-containing mono-oxygenases; EC 1.14.13.8) are microsomal enzymes that catalyse the NADPH-dependent mono-oxygenation of numerous foreign chemicals including therapeutic drugs...
Articles
Biochem J (2007) 403 (3): 593–601.
Published: 12 April 2007
... These authors contributed equally to the study. 3 To whom correspondence should be addressed (email Jacques.philippe@medecine.unige.ch ). 9 1 2007 30 1 2007 30 1 2007 The Authors Journal compilation, The Biochemical Society, London 2007 gene regulation glucagon...
Articles
Biochem J (2007) 402 (2): 359–366.
Published: 12 February 2007
... 2006 6 11 2006 16 11 2006 16 11 2006 The Biochemical Society, London 2007 gene regulation importin α 1 nuclear localization p21 zinc finger zinc-finger protein which regulates apoptosis and cell-cycle arrest 1 (Zac1) Zac1 (zinc-finger protein which regulates...
Articles
Biochem J (2007) 402 (1): 135–141.
Published: 25 January 2007
... whom correspondence should be addressed (email ckm2300@mail.jnu.ac.in ). 26 6 2006 7 9 2006 11 10 2006 11 10 2006 The Biochemical Society, London 2007 activator protein-1 (AP-1) ceruloplasmin copper gene regulation luciferase transcription Cp...
Articles
Biochem J (2006) 396 (2): 371–380.
Published: 15 May 2006
... equally to this work. 2 To whom correspondence should be addressed (email battist@iss.it ). 23 9 2005 2 3 2006 3 3 2006 3 3 2006 The Biochemical Society, London 2006 gene regulation HIV-1 infection interferon-regulatory factor-1 (IRF-1) signal transducer and...
Articles
Biochem J (2006) 394 (1): 125–134.
Published: 27 January 2006
... this paper have been submitted to the GenBank®, DDBJ and EMBL databases under the accession numbers AF462038 (TbNrt2 coding region) and AY786418 (TbNrt2 upstream non-coding region). 25 7 2005 12 9 2005 5 10 2005 5 10 2005 The Biochemical Society, London 2006 gene...
Articles
Biochem J (2005) 392 (1): 1–11.
Published: 08 November 2005
... ). 29 7 2005 10 8 2005 12 8 2005 The Biochemical Society, London 2005 co-repressor gene regulation Krüppel-like factor (KLF) Sp1 transcription factor zinc-finger domain Sp1, the founding member of the family of proteins described in the present review, represents the...
Articles
Biochem J (2005) 388 (3): 913–920.
Published: 07 June 2005
... AY761148 and AY764130. 13 10 2004 20 1 2005 10 2 2005 10 2 2005 The Biochemical Society, London 2005 cis -regulatory element electrophoretic mobility-shift assay gene promoter gene regulation transcription factor vascular endothelial growth inhibitor VEGI...
Articles
Biochem J (2005) 387 (3): 737–745.
Published: 26 April 2005
..., London 2005 cytokine gene regulation signal transduction SOCS3 gene Sp3 transcription factor IL-6 (interleukin-6) belongs to a family of cytokines comprising factors such as IL-11, oncostatin M, LIF (leukaemia inhibitory factor), cardiotrophin-1 and ciliary neurotrophic factor...
Articles
Biochem J (2005) 385 (2): 557–564.
Published: 07 January 2005
...-ku, Sendai 980-8575, Japan. 2 To whom correspondence should be addressed (email yuasa.monc@tmd.ac.jp ). 27 4 2004 5 8 2004 14 9 2004 14 9 2004 The Biochemical Society, London 2005 DNA methyltransferase (DNMT) gene regulation mithramycin A specificity...
Articles
Biochem J (2004) 384 (3): 543–549.
Published: 07 December 2004
... pharmacological approach to up-regulate MnSOD. 1 To whom correspondence should be addressed (email kiningham@marshall.edu ). 29 4 2004 20 8 2004 26 8 2004 26 8 2004 The Biochemical Society, London 2004 cycloheximide gene regulation manganese superoxide dismutase (MnSOD...
Articles
Biochem J (2004) 383 (3): 529–536.
Published: 26 October 2004
... sites are well conserved among human, murine and rat E2F6 core promoters, supporting the hypothesis that they play an essential role in E2F6 gene regulation. As expected, EMSA assays performed with mouse E2F6 probes, encompassing the potential NRF-1 binding sites (−37 to +1 and +2 to +39 relative...
Articles
Biochem J (2004) 381 (2): 503–510.
Published: 06 July 2004
... should be addressed (e-mail Philip.Bufler@med.uni-muenchen.de ). 9 2 2004 25 3 2004 26 3 2004 26 3 2004 The Biochemical Society, London 2004 cytokine gene regulation interleukin 1 lipopolysaccharide monocyte macrophage The IL-1 (interleukin 1) family is an...
Articles
Biochem J (2004) 380 (2): 425–433.
Published: 01 June 2004
... ©2004 2004 cytokine gene regulation T-lymphocyte neuraminidase sialidase Abbreviations used: BAL, bronchoalveolar lavage; G D1a , NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ1-cer; G D1b , Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ1-cer; G M3 , NeuAcα2-3Galβ1-4Glcβ1-cer...
Articles
Biochem J (2004) 380 (2): 455–463.
Published: 01 June 2004
... gene regulation β 2 -glycoprotein I hepatic nuclear factor-1α (HNF-1α) HepG2 cells Huh7 cells Abbreviations used: C/EBPβ, CCAAT/enhancer binding protein β; EMSA, electrophoretic mobility shift assay; β 2 -GPI, β 2 -glycoprotein I; HNF, hepatic nuclear factor; NF-1, nuclear factor-1; SV40...
Articles
Biochem J (2004) 379 (3): 739–747.
Published: 01 May 2004
... (octamer) sequence localized directly downstream of the T1 site. 1 To whom correspondence should be addressed (e-mail wwidlak@io.gliwice.pl ). 1 12 2003 29 1 2004 6 2 2004 6 2 2004 The Biochemical Society, London ©2004 2004 gene regulation heat shock protein Oct...
Articles
Biochem J (2004) 379 (2): 325–330.
Published: 15 April 2004
... 20 1 2004 20 1 2004 The Biochemical Society, London ©2004 2004 λ repressor autocleavage covalent modification by inhibitor gene regulation operator-binding and repressor function self-proteolysis trans -cleavage Abbreviations used: DIFP, di-isopropyl fluorophosphate...
Articles
Biochem J (2004) 378 (3): 839–849.
Published: 15 March 2004
... Society, London ©2004 2004 Forkhead 14-3-3 protein gene regulation growth factor insulin transcription Abbreviations used: DBD, DNA-binding domain; NES, nuclear export sequence; GFP, green fluorescent protein; PKB, protein kinase B; NLS, nuclear localization signal; CK1, casein kinase...
Articles
Biochem J (2004) 377 (3): 763–768.
Published: 01 February 2004
... Biochemical Society, London ©2004 2004 cytokine gene regulation sepsis transcription transcription factor Abbreviations used: DEX, dexamethasone; EMSA, electrophoretic mobility-shift assay; GST, glutathione S-transferase; HNF1, hepatic nuclear factor 1; IL, interleukin; IL6DEX-NP, IL-6-plus...
Articles
Biochem J (2003) 376 (2): 423–431.
Published: 01 December 2003
... 5 9 2003 The Biochemical Society, London ©2003 2003 apolipoprotein atherosclerosis gene regulation hormone nuclear receptor thyroid hormone-responsive element transcriptional synergism Abbreviations used: apoA-II, apolipoprotein A-II; ARP-1, apoA-I regulatory protein 1...
Articles
Biochem J (2003) 375 (2): 365–371.
Published: 15 October 2003
... ©2003 2003 forkhead transcription factor FOXO gene regulation pyruvate dehydrogenase kinase 4 (PDK4) skeletal muscle starvation Abbreviations used: CR, caloric restriction; DBE, DAF-16 family binding element; DMEM, Dulbecco's modified Eagle's medium; FKHR, forkhead homologue in...
Articles
Biochem J (2003) 372 (3): 851–859.
Published: 15 June 2003
... 10 3 2003 The Biochemical Society, London ©2003 2003 c-Myb binding site gene regulation promoter analysis thymus thyrotropin-releasing hormone (TRH) thyrotropin-releasing hormone receptor (TRHR) Abbreviations used: TRH, thyrotropin-releasing hormone; TRHR, TRH receptor...
Articles
Biochem J (2003) 372 (2): 291–304.
Published: 01 June 2003
... apolipoprotein C-II (apoC-II) bile acids gene regulation hepatic control region 1 (HCR-1) hypertriglyceridaemia Abbreviations used: apoC-I (etc.), apolipoprotein C-I (etc.); apoC-I´ apoC-I pseudogene; ARP-1, apoA-I regulatory protein 1; ARP-PO, acidic ribosomal phosphoprotein; CA, cholic acid; CAT...
Articles
Biochem J (2003) 371 (2): 265–275.
Published: 15 April 2003
... Sp1, Sp3, E2F and NF-Y proteins in the cell. 1 To whom correspondence should be addressed (e-mail Cciudad@farmacia.far.ub.es ). 25 7 2002 5 12 2002 3 1 2003 3 1 2003 The Biochemical Society, London ©2003 2003 E2F gene promoter gene regulation nuclear factor Y...
Articles
Biochem J (2003) 370 (3): 979–986.
Published: 15 March 2003
... correspondence should be addressed (e-mail fzafra@cbm.uam.es ). 19 7 2002 15 11 2002 25 11 2002 15 3 2003 The Biochemical Society, London ©2003 2003 Alzheimer's disease apolipoprotein E E-box gene regulation nervous system upstream regulatory factor (USF...
Articles
Biochem J (2003) 370 (3): 771–784.
Published: 15 March 2003
... Society, London ©2003 2003 breast cancer cells gene regulation glutamine hepatoma cancer cells promoter analysis Abbreviations used: C/EBP, CAAT-enhancer binding protein; CREB, cAMP-responsive element binding protein; EMSA, electrophoretic mobility-shift assay; ER, oestrogen receptor...
Articles
Biochem J (2002) 368 (3): 695–704.
Published: 15 December 2002
... 9 2002 The Biochemical Society, London ©2002 2002 alcohol apoptosis fibrogenesis gene regulation green tea extract Abbreviations used: BrdU, bromodeoxyuridine; DMEM, Dulbecco's modified Eagle's medium; ECM, extracellular matrix; EGCG, (—)-epigallocatechin-3-gallate; EMSA...
Articles
Biochem J (2002) 368 (3): 741–751.
Published: 15 December 2002
... ). 17 5 2002 1 8 2002 28 8 2002 28 8 2002 The Biochemical Society, London ©2002 2002 gene regulation promoter analysis Abbreviations used: DOTAP/DOPE, N -[1-(2,3-dioleoyloxy)propyl]- N , N , N -trimethylammonium methylsulphate/dioleoyl phosphatidylethanolamine...
Articles
Biochem J (2002) 367 (3): 641–652.
Published: 01 November 2002
... 7 2002 22 7 2002 The Biochemical Society, London ©2002 2002 enhancer GC box gene regulation HepG2 cells Abbreviations used: AP-1, activator protein-1; ARP, apolipoprotein regulatory protein; CBP, CREB ('cAMP-response-element-binding protein') binding protein; C/EBP...
Articles
Biochem J (2002) 367 (1): 97–105.
Published: 01 October 2002
... (e-mail Bruce.C.Kone@uth.tmc.edu ). 12 4 2002 29 5 2002 11 6 2002 11 6 2002 The Biochemical Society, London ©2002 2002 gene regulation mesangial cell promoter Abbreviations used: CBP, CREB-binding protein; CREB, cAMP-response-element-binding protein; EMSA...