... 2018 gene silencing steroidogenesis TSPO Barron et al. [ 1 ] and Owen et al. [ 2 ] have recently published two interesting papers in the Biochemical Journal , reporting the role of translocator protein (TSPO) in steroidogenesis. Steroids are four-fused-ring organic compounds...

... Limited on behalf of the Biochemical Society 2017 apoptosis gene silencing germ cell GPAT2 meiosis mouse Germ cells were isolated from the testes of inoculated mice as described [ 26 ]. Cells were incubated overnight at 34°C in 4% CO 2 to allow Sertoli cells to adhere to the culture...

... of siRNAs into primary T-cells represents a major hurdle to their use as potential therapeutic agents. Recent advances in siRNA delivery through the use of electroporation/nucleofection, viral vectors, peptides/proteins, nanoparticles, aptamers and other agents have now enabled efficient gene silencing...

... correspondence should be addressed (email [email protected] ). 28 6 2010 9 8 2010 20 8 2010 20 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene silencing hypoxia iron-only hydrogenase-like protein iron-sulfur protein molybdenum cofactor enzyme...

... reduced by 80% and 55–60% respectively in total membranes and BBMs obtained from kidney of megalin antibody-producing rabbits. Immunohistochemical analysis and turnover studies for cubilin in megalin or AMN gene-silenced opossum kidney cells showed a significant reduction (85–90%) in cubilin staining...

... 17 11 2005 The Biochemical Society, London 2006 antisense RNA chemokine receptor gene silencing hammerhead ribozyme HIV ribozyme Hiv-1 entry into human CD4 cells requires the expression of chemokine receptors such as CXCR4 and CCR5 [ 1 ]. It is thought that the binding site...

... of gene silencing. In the present study, we examined the effects of acute loss of Ser/Thr kinase PDK1 (3-phosphoinositide-dependent kinase 1) expression using ASO and RNAi, and compared, for the first time, these two techniques using Affymetrix microarrays. We show that both ASO- and siRNA (small...

... PPD proteins and Dicer regulate gene-silencing at the pre- and post-transcriptional levels. In addition, evidence is beginning to emerge that suggests that these proteins have additional siRNA-independent roles as cell-cycle regulators. In the present review, we summarize the well-known roles...

... of these novel macrophage-tropic DNA enzymes are discussed. 1 To whom correspondence should be addressed (e-mail [email protected] ). 2 1 2001 14 3 2001 4 4 2001 The Biochemical Society, London ©2001 2001 gene silencing gene therapy HIV-1 replication Abbreviations used...

... be addressed (e-mail [email protected] ). 4 9 2000 16 10 2000 16 11 2000 The Biochemical Society, London © 2001 2001 gene cleavage gene silencing gene therapy Biochem. J. (2001) 353, 701 708 (Printed in Great Britain) 701 Inhibition of hepatitis B virus X gene expression...