... expression and activity prevents AngII- and PDGF-dependent phosphorylation of HDAC5. Taken together, these results illustrate a mechanism by which CaMKIIδ 2 mediates MEF2-dependent gene transcription in VSMCs through regulation of HDAC4 and HDAC5. 1 To whom correspondence should be addressed (email...

..., the products were analysed on 1.5% agarose gels. gene transcription metallothionein metal-responsive transcription factor 1 (MTF-1) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) zinc transporter 1 (ZnT1) MTF-1 (metal-responsive transcription factor 1) is an essential gene...

..., suggesting an interference of IEX-1 with the gene transcription of S5a and S1. Additionally, luciferase assays confirmed an interference of IEX-1 with the activity of the S5a promoter. These findings indicate a role of IEX-1 in the maintenance and assembly of the 26 S proteasome, obviously involving...

...′-GGGCCAGGAGTTAAGGAAGA-3′ (303 bp and 63 °C); and mouse GAPDH, 5′-AAGGGCTCATGACCACAGTC-3′ and 5′-CTTACTCCTTGGAGGCCATGT-3′ (495 bp and 68 °C). diabetes mellitus gene transcription insulin gene islets of Langerhans PDX-1 (pancreatic duodenal homeobox factor-1) Expression of the insulin gene in adults...

..., and seems to be common target site for Nrf 2 among vertebrates, although it was shown to be inactive in the rat cells [ 26 ]. 8 11 2004 4 1 2005 17 1 2005 17 1 2005 The Biochemical Society, London 2005 antioxidant-responsive element (ARE) gene transcription glutathione S...

[email protected] ). 25 8 2004 14 10 2004 12 11 2004 12 11 2004 The Biochemical Society, London 2005 cytosolic phospholipase A 2 (cPLA 2 ) gene transcription lung Krüppel-like factor (LKLF) non-small-cell lung cancer (NSCLC) small interfering RNA (siRNA) yeast one-hybrid...

... an insulin-responsive cis -acting unit of the SREBP-1c gene in the liver. 1 To whom correspondence should be addressed (email [email protected] ). 28 1 2004 28 7 2004 26 8 2004 26 8 2004 The Biochemical Society, London 2005 gene transcription hepatocyte insulin...

... 24 9 2003 24 9 2003 The Biochemical Society, London ©2004 2004 gene expression gene transcription haematopoietic differentiation interferon regulatory factor transcription factor Abbreviations used: AP-1, activator protein-1; EMSA, electrophoretic mobility shift assay...

... electrophoretic mobility-shift assays and chromatin immuno- precipitation, we show that E2F1 binds to the Mad3 5«-flanking region both in Šitro and in ŠiŠo. We thus identify Mad3 as a novel transcriptional target of E2F1. Key words: cell cycle, E2F, gene transcription, Mad, Myc. have shown that its expression...

...2002 2002 androgen gene transcription lipoprotein(a) Abbreviations used: apo(a), apolipoprotein(a); DR, direct repeat; ERE, oestrogen receptor response element; ETYA, eicosa-5,8,11,14-tetraynoic acid; IR, inverted repeat; Lp(a), lipoprotein(a); PPAR, peroxisome proliferator-activated...

... stress in the development of insulin resistance, are discussed. Key words: diabetes, gene transcription, phosphorylation, pro- tein kinase B, signalling. the molecules linking PI 3-kinase to these gene promoters remains unclear. We have demonstrated previously [8] that inhibitors of the protein kinase...

..., Heintz, Handt and Sieberth (1998) Hypertension 32 , 945–952]. MCs were grown under atmospheric pressure (AP) or a controlled OP, and protease synthesis and gene transcription were analysed. A distinct biphasic cellular response to OP with stimulated gelatinase A protein expression and enzyme activity...

... FAS gene transcription by Ang II. We demonstrate that Ang II increased luciferase activity by 3-fold in 3T3-L1 adipocytes transfected with fusion constructs linking the FAS promoter to the luciferase reporter gene. Interestingly, we mapped the Ang II regulatory sequences to the insulin-responsive...

... at Ser 329 in vivo . 1 To whom correspondence should be addressed (e-mail [email protected] ). 13 12 2000 5 2 2001 27 2 2001 The Biochemical Society, London © 2001 2001 Akt apoptosis insulin action gene transcription protein kinase B Biochem. J. (2001) 355...

... ligand-activated nuclear receptors, thus creating tightly controlled networks. 1 To whom correspondence should be addressed (e-mail paavo.honkakoski@;uku.fi). The Biochemical Society, London © 2000 2000 endobiotic metabolism gene expression gene transcription ligand-activated...

... such regulation is likely to be at the level of gene transcription, we examined the function of the promoter and other 5ʹ flanking elements of the human γENaC gene. The proximal 5ʹ flanking region contains two GC boxes but does not contain a TATA box. A 450 bp human γENaC fragment (-459 to +40) directed...