... on these discoveries, Greg Semenza, Peter Ratcliffe and William Kaelin Jr [ 6 ]. Genomics tools have been fundamental to understanding gene transcription and chromatin regulation in hypoxia. This includes characterising HIF direct and indirect transcriptional control, identifying the chromatin environment...

... genomes and ortholog mapping of proteins putatively involved in lipid metabolism showed largely conserved lipid biosynthesis pathways suggesting species specific lipid remodeling mechanisms, which possibly have an impact on the response to different light conditions. * Present address: PTJ...

... a eukaryotic invention. We found that some class 2 and thousands of class 1b AdoMetDC homologues are present in bacterial genomes that also encode a gene fusion of an N-terminal membrane protein of the Major Facilitator Superfamily (MFS) class of transporters and a C-terminal SpdSyn-like domain. Although...

... into the thapsigargin backbone is proposed. 1 Correspondence may be addressed to either of these authors (email [email protected] or [email protected] ). 30 4 2012 30 8 2012 31 8 2012 31 8 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 genomics 6...

...Greg B. G. Moorhead; Veerle De Wever; George Templeton; David Kerk Protein phosphorylation appears to be a universal mechanism of protein regulation. Genomics has provided the means to compile inventories of protein phosphatases across a wide selection of organisms and this has supplied insights...

..., London ©2003 2003 genomics polyamine oxidase polyamine analogue spermidine spermidine/spermine N 1 -acetyltransferase spermine oxidase Abbreviations used: N 1 -AcSpd, N 1 -acetylspermidine; N 1 -AcSpm, N 1 -acetylspermine; DASpm, N 1 , N 12 -diacetylspermine; DESpm, N 1...

... and putrescine respectively. Although PAO was first purified more than two decades ago, the protein has not yet been linked to genomic sequences. In the present study, we apply a BLAST search strategy to identify novel oxidase sequences located on human chromosome 10 and mouse chromosome 7. Homologous mammalian...