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Keywords: glucocorticoid receptorClose
Biochem J (2015) 466 (1): 163–176.
Published: 06 February 2015
... the role of protein phosphatase 5 (Ppp5) in glucocorticoid receptor (GR) complexes which mediate response to glucocorticoids. Mice homozygous for inactivated Ppp5 (Ppp5 D274A/D274A ) exhibit decreased adipose tissue surrounding the gonads and kidneys compared with wild-type mice. Adipocyte size is...
Includes: Supplementary data
Meixiu Jiang, Ling Zhang, Xingzhe Ma, Wenquan Hu, Yuanli Chen, Miao Yu, Qixue Wang, Xiaoju Li, Zhinan Yin, Yan Zhu, Xiumei Gao, David P. Hajjar, Yajun Duan, Jihong Han
Biochem J (2013) 454 (3): 467–477.
Published: 29 August 2013
...-hydroxytamoxifen inhibited macrophage FABP4 protein expression induced either by activation of GR (glucocorticoid receptor) or PPARγ (peroxisome-proliferator-activated receptor γ). Associated with the decreased protein expression, Fabp4 mRNA expression and promoter activity were also inhibited by tamoxifen and 4...
Biochem J (2012) 441 (1): 297–303.
Published: 14 December 2011
... activity. BAG-1 has been reported to inhibit the GR (glucocorticoid receptor) and stimulate the androgen receptor, but to leave the activity of the MR (mineralocorticoid receptor) unchanged. Given the high homology between the MR and GR, this disparity in the actions of BAG-1 is surprising. In the present...
Includes: Supplementary data
Biochem J (2003) 376 (1): 285–290.
Published: 15 November 2003
... inhibition of COX2 expression. Nuclear uptake of glucocorticoid receptors mediated by glucocorticoids is also blocked by the simultaneous administration of FK506. These results suggest that the effect of simultaneous treatment of FK506 with glucocorticoids differs significantly from that where pre-treatment...
Biochem J (2003) 373 (1): 211–220.
Published: 01 July 2003
...Christina WIDÉN; Jan-Åke GUSTAFSSON; Ann-Charlotte WIKSTRÖM The glucocorticoid receptor (GR) acts as an anti-inflammatory factor. To a large extent, this activity is exerted by the interference of pro-inflammatory nuclear factor κB (NF-κB) activity. In their respective inactive forms, both GR and...
Biochem J (2001) 353 (3): 611–620.
Published: 25 January 2001
... bind specific DNA sequences, called hormone response elements, located near the target genes. Although the androgen receptor (AR) and the glucocorticoid receptor (GR) bind the same consensus DNA sequence, androgen-specific responses can be achieved by non-conventional androgen response elements (AREs...
Biochem J (2000) 350 (1): 123–129.
Published: 09 August 2000
... called GRE A. GRE A is composed of two overlapping imperfect GREs, each comprising a conserved half-site (half-sites 1 and 4 respectively) and a poorly conserved half-site (half-sites 2 and 3 respectively). The sequence binds co-operatively two dimers of the glucocorticoid receptor (GR) and mediates...