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Keywords: gluconeogenesis
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Articles
Biochem J (2020) 477 (5): 1021–1031.
Published: 13 March 2020
...Lina He; Yang Li; Ni Zeng; Bangyan L. Stiles Hepatic glucose metabolism signaling downstream of insulin can diverge to multiple pathways including AKT. Genetic studies suggest that AKT is necessary for insulin to suppress gluconeogenesis. To specifically address the role of AKT2, the dominant liver...
Articles
Biochem J (2018) 475 (6): 1063–1074.
Published: 20 March 2018
... and death; however, the molecular mechanisms by which MCPA and MCPG cause hypoglycemia have not been established in vivo . To determine the in vivo mechanisms of action of these toxins, we infused them into conscious rodents and assessed rates of hepatic gluconeogenesis and ketogenesis, hepatic acyl-CoA...
Includes: Supplementary data
Articles
Biochem J (2015) 472 (2): 225–237.
Published: 13 November 2015
... relationship to related pathologies, such as diabetes. In order to gain insight into the regulation of glucose metabolism, we studied the liver-expressed isoforms aldolase B and fructose-1,6-bisphosphatase-1 (FBPase-1), key enzymes in gluconeogenesis, analysing their cellular localization in hepatocytes under...
Includes: Supplementary data
Articles
Biochem J (2013) 455 (2): 207–216.
Published: 27 September 2013
... in Type 2 diabetes. APPL1 [adaptor protein, phosphotyrosine interaction, PH (pleckstrin homology) domain and leucine zipper containing 1] sensitizes hepatic insulin action on suppression of gluconeogenesis by binding to Akt. However, the mechanisms underlying the insulin-sensitizing actions of APPL1...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (3): 537–551.
Published: 29 May 2012
... and outflow of lactate. The present study provides a deeper insight into the hepatic actions of GKAs and uncovers the potential benefits and risks of GKA for treatment of diabetes. GKA improved hepatic bioenergetics, ureagenesis and glycogenesis, but decreased gluconeogenesis with a potential risk of lactic...
Includes: Supplementary data
Articles
Biochem J (2008) 413 (3): 559–569.
Published: 15 July 2008
... of gluconeogenesis. The reporter plasmids OATP (organic anion transporting polypeptide)-C128/Luc, 6×FoxA (forkhead box A2, previously called HNF-3β)-Luc, 8×HNF-4α-Luc, 6×HNF-6-Luc and G6Pase-Luc were previously described in [ 7 ]. PEPCK-Luc was provided by Dr Richard W. Hanson (Case Western Reserve...
Includes: Supplementary data
Articles
Biochem J (2007) 407 (3): 373–381.
Published: 12 October 2007
... immunoprecipitation) assays were performed to show a decreased CREB binding to the G6Pase promoter in fasting wild-type mice after PCN treatment. Thus drug activation of PXR can repress the transcriptional activity of CREB, down-regulating gluconeogenesis. 1 To whom correspondence should be addressed (email...
Articles
Biochem J (2007) 401 (2): 465–473.
Published: 21 December 2006
...Guy Martin; Bernard Ferrier; Agnès Conjard; Mireille Martin; Rémi Nazaret; Michelle Boghossian; Fadi Saadé; Claire Mancuso; Daniel Durozard; Gabriel Baverel Recent reports have indicated that 48–72 h of fasting, Type 1 diabetes and high-protein feeding induce gluconeogenesis in the small intestine...
Articles
Biochem J (2006) 394 (2): 465–473.
Published: 10 February 2006
... output unchanged. When lactate and pyruvate were eliminated from the perfusion medium, both gluconeogenesis and tricarboxylic-acid-cycle flux were dramatically lower. Insulin lowered glucose production by inhibiting glycogenolysis at both low and high doses, but only at high levels of insulin did...
Articles
Biochem J (2005) 387 (3): 825–834.
Published: 26 April 2005
... 2004 17 11 2004 3 12 2004 3 12 2004 The Biochemical Society, London 2005 ammoniagenesis 13 C NMR gluconeogenesis glutamine metabolism human kidney valproate It is well established that the human kidney takes up glutamine from the circulating blood under various...
Articles
Biochem J (2005) 385 (3): 639–648.
Published: 24 January 2005
... protein 1), which regulate gluconeogenesis, are no longer controlled by feeding. Furthermore, three other insulin-controlled genes, namely IGFBP1 (insulin-like-growth-factor-binding protein-1), IRS2 (insulin receptor substrate 2) and glucokinase, were regulated abnormally by feeding in the liver of PDK1...
Articles
Biochem J (2004) 382 (2): 471–479.
Published: 24 August 2004
... propose that NFκB does not act by binding directly to the G6Pase promoter. 1 To whom correspondence should be addressed (email dieter.schmoll@aventis.com ). 28 1 2004 6 5 2004 28 5 2004 28 5 2004 The Biochemical Society, London 2004 diabetes gluconeogenesis...
Articles
Biochem J (2004) 378 (2): 485–495.
Published: 01 March 2004
... glutamate degradation only by decreasing flux through glutamate dehydrogenase in the reductive amination direction, but surprisingly did not significantly alter complete oxidation of the glutamine carbon skeleton. Finally, gluconeogenesis from glutamine involved not only substantial recycling through...
Articles
Biochem J (2003) 375 (3): 729–736.
Published: 01 November 2003
... histolytica gluconeogenesis glycerate dehydrogenase serine biosynthesis Abbreviations used: DTT, dithiothreitol; (Eh)GDH, ( Entamoeba histolytica ) d -glycerate dehydrogenase; GK, glycerate kinase; HP, β-hydroxypyruvate; OAS, O -acetylserine; ORF, open reading frame; PGDH, phosphoglycerate...
Articles
Biochem J (2003) 370 (2): 409–415.
Published: 01 March 2003
... number AB087802. 19 7 2002 8 11 2002 12 11 2002 12 11 2002 The Biochemical Society, London ©2003 2003 gluconeogenesis glycogen nucleotide-sugar Abbreviations used: G1P, glucose 1-phosphate; UDPG, UDP-glucose; UGPase, UDPG pyrophosphorylase; UGPPase, UDPG...
Articles
Biochem J (2003) 369 (1): 17–22.
Published: 01 January 2003
..., respiration and therm- ogenesis (reviewed in [6 as well as hepatic gluconeogenesis [7,8]. Recently, two PGC-1a homologues have been identified, PGC-1b [9] and PGC-1-related co-activator ( PRC ) [10]. In liver, expression of both PGC-1a and PGC-1b are markedly induced by fasting [9], and adenoviral-mediated...
Articles
Biochem J (2002) 366 (2): 377–391.
Published: 01 September 2002
...Fabienne FOUFELLE; Pascal FERRÉ The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways are regulated at several levels...
Articles
Biochem J (2002) 365 (2): 391–403.
Published: 15 July 2002
... from cytosol, as well as for d -lactate-dependent gluconeogenesis. 1 To whom correspondence should be addressed (e-mail passarel@unimol.it ). 23 1 2002 3 4 2002 9 4 2002 The Biochemical Society, London ©2002 2002 antiporter dehydrogenase flavoprotein...
Articles
Biochem J (2002) 362 (3): 513–532.
Published: 08 March 2002
... be addressed (e-mail vanschaftingen@bchm.ucl.ac.be ). 2 Present address: Department of Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. The Biochemical Society, London ©2002 2002 gluconeogenesis glucose 6-phosphate glycogen glycogen storage disease transporter...
Articles
Biochem J (2001) 358 (3): 569–571.
Published: 10 September 2001
... more alkaline than perivenous cells. In the present studies, the perivenous 21% of the lobular volume was destroyed by retrograde digitonin perfusion, and antegrade perfusion restored. pH i was determined by 31 P-NMR. The remaining periportal cells, the site of gluconeogenesis from lactate, had...
Articles
Biochem J (2001) 357 (3): 867–873.
Published: 25 July 2001
... equally to this work. 2 To whom correspondence should be addressed (e-mail schmoll@mail.uni-greifswald.de ). 15 3 2001 8 5 2001 31 5 2001 The Biochemical Society, London ©2001 2001 diabetes gluconeogenesis insulin liver protein kinase B Abbreviations used...
Articles
Biochem J (2000) 352 (1): 211–217.
Published: 07 November 2000
... action of insulin was exerted through the PI 3- kinase pathway in cultured rat hepatocytes. Key words: gluconeogenesis, HepG2 cells, liver, phospho- inositide 3-kinase. required for its stimulation by cAMP [18], are highly conserved in the human promoter. An insulin-responsive region, which has been...
Articles
Biochem J (2000) 348 (3): 607–614.
Published: 07 June 2000
... of gluconeogenesis from L -lactate in isolated rat hepatocytes was also time- and concentration-dependent, and accompanied by changes in metabolite levels similar to those induced by other inhibitors of gluconeogenesis acting on complex 1. Freeze-clamped livers from metformin-treated rats exhibited similar changes...
Articles
Biochem J (2000) 347 (2): 459–467.
Published: 10 April 2000
... To whom correspondence should be addressed (e-mail ikurland@;mednet.ucla.edu). 5 8 1999 17 11 1999 24 1 2000 The Biochemical Society, London © 2000 2000 enzyme kinetics gluconeogenesis glycolysis hepatic glucose metabolism structure/function Biochem. J. (2000) 347, 459...
Articles
Biochem J (1999) 340 (1): 1–16.
Published: 10 May 1999
... in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucose-induced insulin secretion by pancreatic islets. The reaction catalysed by PC and the physical properties of the enzyme have been studied extensively. Although no high-resolution three-dimensional structure has yet...
Articles
Biochem J (1999) 339 (3): 563–569.
Published: 26 April 1999
...-dependent induction by glucagon of PCK1 gene transcription. 1 To whom correspondence should be addressed (e-mail kjunger@gwdg.de). 19 10 1998 15 1 1999 10 2 1999 The Biochemical Society, London © 1999 1999 cAMP-response element gluconeogenesis hypoxia metabolic...
Articles
Biochem J (1999) 338 (2): 457–463.
Published: 22 February 1999
... (e-mail schmoll@rz.uni-greifswald.de ). The sequence data reported in this article have been deposited with the GenBank database under accession number AF051355. 9 10 1998 18 12 1998 The Biochemical Society, London © 1999 1999 gluconeogenesis insulin liver...