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Keywords: gluconeogenesis
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Biochem J (2023) 480 (1): 105–125.
Published: 13 January 2023
...Manuel Johanns; Louis Hue; Mark H. Rider Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of AMPK...
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Biochem J (2020) 477 (5): 1021–1031.
Published: 13 March 2020
...Lina He; Yang Li; Ni Zeng; Bangyan L. Stiles Hepatic glucose metabolism signaling downstream of insulin can diverge to multiple pathways including AKT. Genetic studies suggest that AKT is necessary for insulin to suppress gluconeogenesis. To specifically address the role of AKT2, the dominant liver...
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Biochem J (2018) 475 (6): 1063–1074.
Published: 20 March 2018
... and death; however, the molecular mechanisms by which MCPA and MCPG cause hypoglycemia have not been established in vivo . To determine the in vivo mechanisms of action of these toxins, we infused them into conscious rodents and assessed rates of hepatic gluconeogenesis and ketogenesis, hepatic acyl-CoA...
Includes: Supplementary data
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Biochem J (2013) 455 (2): 207–216.
Published: 27 September 2013
... in Type 2 diabetes. APPL1 [adaptor protein, phosphotyrosine interaction, PH (pleckstrin homology) domain and leucine zipper containing 1] sensitizes hepatic insulin action on suppression of gluconeogenesis by binding to Akt. However, the mechanisms underlying the insulin-sensitizing actions of APPL1...
Includes: Supplementary data
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Biochem J (2012) 444 (3): 537–551.
Published: 29 May 2012
... and outflow of lactate. The present study provides a deeper insight into the hepatic actions of GKAs and uncovers the potential benefits and risks of GKA for treatment of diabetes. GKA improved hepatic bioenergetics, ureagenesis and glycogenesis, but decreased gluconeogenesis with a potential risk of lactic...
Includes: Supplementary data
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Biochem J (2008) 413 (3): 559–569.
Published: 15 July 2008
... of gluconeogenesis. 1 To whom correspondence should be addressed (email hsc@chonnam.ac.kr ). In this study, we have investigated the effect of SHP on HNF-6. We have demonstrated that SHP physically interacts with HNF-6 and represses HNF-6 transcriptional activity by blocking the ability of HNF-6 to bind...
Includes: Supplementary data
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Biochem J (2007) 407 (3): 373–381.
Published: 12 October 2007
... immunoprecipitation) assays were performed to show a decreased CREB binding to the G6Pase promoter in fasting wild-type mice after PCN treatment. Thus drug activation of PXR can repress the transcriptional activity of CREB, down-regulating gluconeogenesis. 1 To whom correspondence should be addressed (email...
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Biochem J (2005) 387 (3): 825–834.
Published: 26 April 2005
... chemicals used were of analytical grade. 1 To whom correspondence should be addressed (email baverel@sante.univ-lyon1.fr ). 2 8 2004 17 11 2004 3 12 2004 3 12 2004 The Biochemical Society, London 2005 ammoniagenesis 13 C NMR gluconeogenesis glutamine...
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Biochem J (2005) 385 (3): 639–648.
Published: 24 January 2005
... protein 1), which regulate gluconeogenesis, are no longer controlled by feeding. Furthermore, three other insulin-controlled genes, namely IGFBP1 (insulin-like-growth-factor-binding protein-1), IRS2 (insulin receptor substrate 2) and glucokinase, were regulated abnormally by feeding in the liver of PDK1...
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Biochem J (2004) 378 (2): 485–495.
Published: 01 March 2004
... glutamate degradation only by decreasing flux through glutamate dehydrogenase in the reductive amination direction, but surprisingly did not significantly alter complete oxidation of the glutamine carbon skeleton. Finally, gluconeogenesis from glutamine involved not only substantial recycling through...
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Biochem J (2002) 365 (2): 391–403.
Published: 15 July 2002
... from cytosol, as well as for d -lactate-dependent gluconeogenesis. Biochem. J. (2002) 365, 391 403 (Printed in Great Britain) 391 D-Lactate transport and metabolism in rat liver mitochondria Lidia DE BARI*, Anna ATLANTE‹, Nicoletta GUARAGNELLA*, Giovanni PRINCIPATOŒ and Salvatore PASSARELLA1...
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Biochem J (2002) 362 (3): 513–532.
Published: 08 March 2002
... be addressed (e-mail vanschaftingen@bchm.ucl.ac.be ). 2 Present address: Department of Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. The Biochemical Society, London ©2002 2002 gluconeogenesis glucose 6-phosphate glycogen glycogen storage disease transporter...
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Biochem J (2001) 358 (3): 569–571.
Published: 10 September 2001
... more alkaline than perivenous cells. In the present studies, the perivenous 21% of the lobular volume was destroyed by retrograde digitonin perfusion, and antegrade perfusion restored. pH i was determined by 31 P-NMR. The remaining periportal cells, the site of gluconeogenesis from lactate, had...
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Biochem J (2000) 348 (3): 607–614.
Published: 07 June 2000
... of gluconeogenesis from L -lactate in isolated rat hepatocytes was also time- and concentration-dependent, and accompanied by changes in metabolite levels similar to those induced by other inhibitors of gluconeogenesis acting on complex 1. Freeze-clamped livers from metformin-treated rats exhibited similar changes...
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Biochem J (2000) 347 (2): 459–467.
Published: 10 April 2000
... activities to work in the physiological range of pH and substrate concen- trations found in each particular tissue. Key words: enzyme kinetics, gluconeogenesis, glycolysis, hepatic glucose metabolism, structure}function. ditional level of control [1]. Recently, the X-ray crystallographic analysis...
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Biochem J (1999) 340 (1): 1–16.
Published: 10 May 1999
... in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucose-induced insulin secretion by pancreatic islets. The reaction catalysed by PC and the physical properties of the enzyme have been studied extensively. Although no high-resolution three-dimensional structure has yet...
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