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1-29 of 29
Keywords: gluconeogenesis
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In Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (1): 105–125.
Published: 13 January 2023
...Manuel Johanns; Louis Hue; Mark H. Rider Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of AMPK...
Articles
Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider
Journal:
Biochemical Journal
Biochem J (2022) 479 (12): 1317–1336.
Published: 22 June 2022
... properties. The main aim was to investigate the effects of 991 and other direct AMPK activators on HGP and determine whether the observed effects were AMPK-dependent. In incubated hepatocytes, 991 substantially decreased gluconeogenesis from lactate, pyruvate and glycerol, but not from other substrates...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (5): 1021–1031.
Published: 13 March 2020
...Lina He; Yang Li; Ni Zeng; Bangyan L. Stiles Hepatic glucose metabolism signaling downstream of insulin can diverge to multiple pathways including AKT. Genetic studies suggest that AKT is necessary for insulin to suppress gluconeogenesis. To specifically address the role of AKT2, the dominant liver...
Articles
Yang Qiu, Rachel J. Perry, João-Paulo G. Camporez, Xian-Man Zhang, Mario Kahn, Gary W. Cline, Gerald I. Shulman, Daniel F. Vatner
Journal:
Biochemical Journal
Biochem J (2018) 475 (6): 1063–1074.
Published: 20 March 2018
... and death; however, the molecular mechanisms by which MCPA and MCPG cause hypoglycemia have not been established in vivo . To determine the in vivo mechanisms of action of these toxins, we infused them into conscious rodents and assessed rates of hepatic gluconeogenesis and ketogenesis, hepatic acyl-CoA...
Includes: Supplementary data
Articles
Cristian A. Droppelmann, Doris E. Sáez, Joel L. Asenjo, Alejandro J. Yáñez, Mar García-Rocha, Ilona I. Concha, Manuel Grez, Joan J. Guinovart, Juan C. Slebe
Journal:
Biochemical Journal
Biochem J (2015) 472 (2): 225–237.
Published: 13 November 2015
... relationship to related pathologies, such as diabetes. In order to gain insight into the regulation of glucose metabolism, we studied the liver-expressed isoforms aldolase B and fructose-1,6-bisphosphatase-1 (FBPase-1), key enzymes in gluconeogenesis, analysing their cellular localization in hepatocytes under...
Includes: Supplementary data
Articles
Kenneth K. Y. Cheng, Karen S. L. Lam, Yu Wang, Donghai Wu, Mingliang Zhang, Baile Wang, Xiaomu Li, Ruby L. C. Hoo, Zhe Huang, Gary Sweeney, Aimin Xu
Journal:
Biochemical Journal
Biochem J (2013) 455 (2): 207–216.
Published: 27 September 2013
... in Type 2 diabetes. APPL1 [adaptor protein, phosphotyrosine interaction, PH (pleckstrin homology) domain and leucine zipper containing 1] sensitizes hepatic insulin action on suppression of gluconeogenesis by binding to Akt. However, the mechanisms underlying the insulin-sensitizing actions of APPL1...
Includes: Supplementary data
Articles
Itzhak Nissim, Oksana Horyn, Ilana Nissim, Yevgeny Daikhin, Suzanne L. Wehrli, Marc Yudkoff, Franz M. Matschinsky
Journal:
Biochemical Journal
Biochem J (2012) 444 (3): 537–551.
Published: 29 May 2012
... and outflow of lactate. The present study provides a deeper insight into the hepatic actions of GKAs and uncovers the potential benefits and risks of GKA for treatment of diabetes. GKA improved hepatic bioenergetics, ureagenesis and glycogenesis, but decreased gluconeogenesis with a potential risk of lactic...
Includes: Supplementary data
Articles
Yong-Soo Lee, Don-Kyu Kim, Yong Deuk Kim, Ki Cheol Park, Minho Shong, Hyun-A Seong, Hyun Jung Ha, Hueng-Sik Choi
Journal:
Biochemical Journal
Biochem J (2008) 413 (3): 559–569.
Published: 15 July 2008
... of gluconeogenesis. 1 To whom correspondence should be addressed (email [email protected] ). © The Authors Journal compilation © 2008 Biochemical Society 2008 small heterodimer partner (SHP) gluconeogenesis glucose 6-phosphatase hepatocyte nuclear factor-6 (HNF-6) phosphoenolpyruvate...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2007) 407 (3): 373–381.
Published: 12 October 2007
... immunoprecipitation) assays were performed to show a decreased CREB binding to the G6Pase promoter in fasting wild-type mice after PCN treatment. Thus drug activation of PXR can repress the transcriptional activity of CREB, down-regulating gluconeogenesis. 1 To whom correspondence should be addressed (email...
Articles
Guy Martin, Bernard Ferrier, Agnès Conjard, Mireille Martin, Rémi Nazaret, Michelle Boghossian, Fadi Saadé, Claire Mancuso, Daniel Durozard, Gabriel Baverel
Journal:
Biochemical Journal
Biochem J (2007) 401 (2): 465–473.
Published: 21 December 2006
...Guy Martin; Bernard Ferrier; Agnès Conjard; Mireille Martin; Rémi Nazaret; Michelle Boghossian; Fadi Saadé; Claire Mancuso; Daniel Durozard; Gabriel Baverel Recent reports have indicated that 48–72 h of fasting, Type 1 diabetes and high-protein feeding induce gluconeogenesis in the small intestine...
Articles
Natasha Hausler, Jeffrey Browning, Matthew Merritt, Charles Storey, Angela Milde, F. Mark H. Jeffrey, A. Dean Sherry, Craig R. Malloy, Shawn C. Burgess
Journal:
Biochemical Journal
Biochem J (2006) 394 (2): 465–473.
Published: 10 February 2006
... output unchanged. When lactate and pyruvate were eliminated from the perfusion medium, both gluconeogenesis and tricarboxylic-acid-cycle flux were dramatically lower. Insulin lowered glucose production by inhibiting glycogenolysis at both low and high doses, but only at high levels of insulin did...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 387 (3): 825–834.
Published: 26 April 2005
... medium and compared with total LDH activity (extracellular+intracellular LDH). LDH activity was determined using the method described by Bergmeyer and Bernt [ 24 ]. ammoniagenesis 13 C NMR gluconeogenesis glutamine metabolism human kidney valproate It is well established...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 385 (3): 639–648.
Published: 24 January 2005
... protein 1), which regulate gluconeogenesis, are no longer controlled by feeding. Furthermore, three other insulin-controlled genes, namely IGFBP1 (insulin-like-growth-factor-binding protein-1), IRS2 (insulin receptor substrate 2) and glucokinase, were regulated abnormally by feeding in the liver of PDK1...
Articles
Rolf GREMPLER, Anne KIENITZ, Torsten WERNER, Marion MEYER, Andreas BARTHEL, Fabienne AILETT, Calum SUTHERLAND, Reinhard WALTHER, Dieter SCHMOLL
Journal:
Biochemical Journal
Biochem J (2004) 382 (2): 471–479.
Published: 24 August 2004
... 28 5 2004 The Biochemical Society, London 2004 diabetes gluconeogenesis glucose-6-phosphatase insulin liver sepsis G6Pase (glucose-6-phosphatase) catalyses the final step of the metabolic pathways that are central to hepatic glucose production, i.e. gluconeogenesis...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 378 (2): 485–495.
Published: 01 March 2004
... glutamate degradation only by decreasing flux through glutamate dehydrogenase in the reductive amination direction, but surprisingly did not significantly alter complete oxidation of the glutamine carbon skeleton. Finally, gluconeogenesis from glutamine involved not only substantial recycling through...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (3): 729–736.
Published: 01 November 2003
... histolytica gluconeogenesis glycerate dehydrogenase serine biosynthesis Abbreviations used: DTT, dithiothreitol; (Eh)GDH, ( Entamoeba histolytica ) d -glycerate dehydrogenase; GK, glycerate kinase; HP, β-hydroxypyruvate; OAS, O -acetylserine; ORF, open reading frame; PGDH, phosphoglycerate...
Articles
Toshihiro YAGI, Edurne BAROJA-FERNÁNDEZ, Ryuji YAMAMOTO, Francisco José MUÑOZ, Takashi AKAZAWA, Kyoung Su HONG, Javier POZUETA-ROMERO
Journal:
Biochemical Journal
Biochem J (2003) 370 (2): 409–415.
Published: 01 March 2003
... number AB087802. 19 7 2002 8 11 2002 12 11 2002 12 11 2002 The Biochemical Society, London ©2003 2003 gluconeogenesis glycogen nucleotide-sugar Abbreviations used: G1P, glucose 1-phosphate; UDPG, UDP-glucose; UGPase, UDPG pyrophosphorylase; UGPPase, UDPG...
Articles
Jared N. BOUSTEAD, Beth T. STADELMAIER, Angela M. EEDS, Peter O. WIEBE, Christina A. SVITEK, James K. OESER, Richard M. O'BRIEN
Journal:
Biochemical Journal
Biochem J (2003) 369 (1): 17–22.
Published: 01 January 2003
... nuclear factor-4α. 1 To whom correspondence should be addressed (e-mail [email protected] ). 2 9 2002 11 10 2002 5 11 2002 5 11 2002 The Biochemical Society, London ©2003 2003 diabetes gluconeogenesis HNF-4 gluconeogenesis phosphoenolpyruvate...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 366 (2): 377–391.
Published: 01 September 2002
...Fabienne FOUFELLE; Pascal FERRÉ The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways are regulated at several levels...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 365 (2): 391–403.
Published: 15 July 2002
... from cytosol, as well as for d -lactate-dependent gluconeogenesis. 1 To whom correspondence should be addressed (e-mail [email protected] ). 23 1 2002 3 4 2002 9 4 2002 The Biochemical Society, London ©2002 2002 antiporter dehydrogenase flavoprotein...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 362 (3): 513–532.
Published: 08 March 2002
... be addressed (e-mail [email protected] ). 2 Present address: Department of Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. The Biochemical Society, London ©2002 2002 gluconeogenesis glucose 6-phosphate glycogen glycogen storage disease transporter...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 358 (3): 569–571.
Published: 10 September 2001
... more alkaline than perivenous cells. In the present studies, the perivenous 21% of the lobular volume was destroyed by retrograde digitonin perfusion, and antegrade perfusion restored. pH i was determined by 31 P-NMR. The remaining periportal cells, the site of gluconeogenesis from lactate, had...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 357 (3): 867–873.
Published: 25 July 2001
... equally to this work. 2 To whom correspondence should be addressed (e-mail [email protected] ). 15 3 2001 8 5 2001 31 5 2001 The Biochemical Society, London ©2001 2001 diabetes gluconeogenesis insulin liver protein kinase B Abbreviations used...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 352 (1): 211–217.
Published: 07 November 2000
... action of insulin was exerted through the PI 3- kinase pathway in cultured rat hepatocytes. Key words: gluconeogenesis, HepG2 cells, liver, phospho- inositide 3-kinase. required for its stimulation by cAMP [18], are highly conserved in the human promoter. An insulin-responsive region, which has been...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 348 (3): 607–614.
Published: 07 June 2000
... of gluconeogenesis from L -lactate in isolated rat hepatocytes was also time- and concentration-dependent, and accompanied by changes in metabolite levels similar to those induced by other inhibitors of gluconeogenesis acting on complex 1. Freeze-clamped livers from metformin-treated rats exhibited similar changes...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 347 (2): 459–467.
Published: 10 April 2000
... activities to work in the physiological range of pH and substrate concen- trations found in each particular tissue. Key words: enzyme kinetics, gluconeogenesis, glycolysis, hepatic glucose metabolism, structure}function. ditional level of control [1]. Recently, the X-ray crystallographic analysis...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 340 (1): 1–16.
Published: 10 May 1999
... in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and in glucose-induced insulin secretion by pancreatic islets. The reaction catalysed by PC and the physical properties of the enzyme have been studied extensively. Although no high-resolution three-dimensional structure has yet...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 339 (3): 563–569.
Published: 26 April 1999
...-dependent induction by glucagon of PCK1 gene transcription. 1 To whom correspondence should be addressed (e-mail [email protected]). 19 10 1998 15 1 1999 10 2 1999 The Biochemical Society, London © 1999 1999 cAMP-response element gluconeogenesis hypoxia metabolic...
Articles
Dieter SCHMOLL, Christina WASNER, Carolyn J. HINDS, Bernard B. ALLAN, Reinhard WALTHER, Ann BURCHELL
Journal:
Biochemical Journal
Biochem J (1999) 338 (2): 457–463.
Published: 22 February 1999
... 1 To whom correspondence should be addressed (e-mail [email protected] ). The sequence data reported in this article have been deposited with the GenBank database under accession number AF051355. 9 10 1998 18 12 1998 gluconeogenesis insulin liver...