...). Allosteric mechanisms involving glucose 6-phosphate or xylulose 5-phosphate and covalent modification of ChREBP (carbohydrate-response element-binding protein) have been implicated in this mechanism. However, evidence supporting an essential role for a specific metabolite or pathway in hepatocytes remains...

... accumulation of hepatic glycogen content and an induction of de novo lipogenesis. The chlorogenic acid derivative S4048 is a pharmacological inhibitor of the glucose 6-phosphate transporter, which is part of glucose-6-phosphatase, and allows for mechanistic studies concerning metabolic defects in GSD-1...

... glycation end-products) in various tissues, including the lens. Nevertheless, glycation of α-crystallin with various sugars has resulted in divergent results. In the present in vitro study, we have investigated the effect of glucose, fructose, G6P (glucose 6-phosphate) and MGO (methylglyoxal), which...

...Susan AISTON; Andrew GREEN; Mohammed MUKHTAR; Loranne AGIUS The role of glucose 6-P (glucose 6-phosphate) in regulating the activation state of glycogen synthase and its translocation is well documented. In the present study, we investigated the effects of glucose 6-P on the activation state...

...]. Substrate would be provided to this enzyme by a translocase that is specific for glucose 6-phosphate, thereby accounting for the specificity of the phosphatase for glucose 6-phosphate in intact microsomes. Distinct transporters would allow inorganic phosphate and glucose to leave the vesicles. At variance...

...Lori A. GUSTAFSON; Mies NEEFT; Dirk-Jan REIJNGOUD; Folkert KUIPERS; Hans P. SAUERWEIN; Johannes A. ROMIJN; Andreas W. HERLING; Hans-Joerg BURGER; Alfred J. MEIJER We studied the influence of glucose/glucose 6-phosphate cycling on glycogen deposition from glucose in fasted-rat hepatocytes using...

...-aminoisobutyrate, ATP, glucose 6-phosphate (Glc6 P ) and fructose 2,6-bisphosphate [Fru(2,6) P 2 ], but maintain cell integrity in the presence of ATP as judged by the retention of cytoplasmic enzymes. During incubation with 25mM glucose, an ATP-generating system and saturating concentrations of Fru(2,6) P 2...

...Simon R. FOX; Lionel M. HILL; Stephen RAWSTHORNE; Matthew J. HILLS Addition of oleoyl-CoA (1 µ M), or other acyl-CoA thioesters with a chain length of C 16 or greater, to oilseed rape plastids ( Brassica napus L.) inhibited the rate of D -glucose 6-phosphate (Glc6P) uptake by 70% after 2min. The IC...

... correspondence should be addressed at the National Institute of Occupational Health (e-mail jorgen.jensen @stami.no). 8 2 1999 11 8 1999 6 9 1999 The Biochemical Society, London © 1999 1999 electrical stimulation glucose 6-phosphate insulin Biochem. J. (1999) 344, 231 235...