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Keywords: glucose transport
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Biochem J (2022) 479 (11): 1237–1256.
Published: 13 June 2022
... BY) . adipocytes glucose transport glycogen synthase kinase insulin signalling trafficking regulator of GLUT4-1 Insulin maintains whole-body glucose homeostasis by regulating glucose transport into muscle and adipose tissue and by inhibiting glucose output from liver. Defects in these processes cause...
Includes: Supplementary data
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Biochem J (2022) 479 (3): 445–462.
Published: 11 February 2022
...Daniel J. Fazakerley; Francoise Koumanov; Geoffrey D. Holman Insulin rapidly stimulates GLUT4 translocation and glucose transport in fat and muscle cells. Signals from the occupied insulin receptor are translated into downstream signalling changes in serine/threonine kinases within timescales...
Includes: Supplementary data
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Biochem J (2021) 478 (21): 3869–3889.
Published: 09 November 2021
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 ACC AMPK de novo lipogenesis glucose transport GPAT TBC1D4 AMP-activated protein kinase (AMPK) is highly conserved energy sensing eukaryotic protein kinase [ 1 ]. Once activated, AMPK switches...
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Biochem J (2021) 478 (7): 1315–1319.
Published: 06 April 2021
... (2): 407–422) of complexin-2 as an important contributor to glucose transporter 4 (GLUT4) translocation to muscle cell plasma membrane upon insulin stimulation is essential. The present commentary discusses the biological importance of the findings and proposes future challenges and opportunities...
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Biochem J (2020) 477 (10): 1795–1811.
Published: 21 May 2020
... glucose transport glycolysis osteoblasts p53 Oxidative phosphorylation has higher efficiency of ATP production than glycolysis and is the main source of ATP in mammalian cells under aerobic conditions. In cancer cells, however, most glucose is metabolized to lactate even in the existence...
Includes: Supplementary data
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Biochem J (2019) 476 (19): 2851–2867.
Published: 11 October 2019
... availabilities within their propagated environments. Disruption of the C. burnetii glucose transporter, CBU0265, by transposon mutagenesis led to a significant decrease in [ 13 C]glucose utilization but did not abolish glucose usage, suggesting that C. burnetii express additional hexose transporters which may...
Includes: Supplementary data
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Biochem J (2018) 475 (10): 1807–1820.
Published: 31 May 2018
... in adipocytes from patients with diabetes. To elucidate the effect of reduced FOXO1 activity, we here transduced human adipocytes with a dominant-negative construct of FOXO1 (DN-FOXO1). Inhibition of FOXO1 reduced the abundance of insulin receptor, glucose transporter-4, ribosomal protein S6, mTOR and raptor...
Includes: Supplementary data
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Biochem J (2013) 456 (2): 219–229.
Published: 08 November 2013
...-like peptides and AGE-1 [ageing alteration 1; orthologue of PI3K (phosphoinositide 3-kinase)], but the identity of the glucose transporters that may link these processes is unknown. We unexpectedly find that of the eight putative GLUT (glucose transporter)-like genes only the two splice variants of one...
Includes: Supplementary data
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Biochem J (2013) 449 (2): 479–489.
Published: 14 December 2012
...Hong Yu Wang; Serge Ducommun; Chao Quan; Bingxian Xie; Min Li; David H. Wasserman; Kei Sakamoto; Carol Mackintosh; Shuai Chen AS160 (Akt substrate of 160 kDa) is a Rab GTPase-activating protein implicated in insulin control of GLUT4 (glucose transporter 4) trafficking. In humans, a truncation...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 587–601.
Published: 16 April 2012
... 1 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell migration glucose transport insulin secretion phosphoinositide phosphoinositide 3-kinase (PI3K) Phosphoinositides are phospholipids comprising two fatty acid chains linked by a glycerol moiety...
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Biochem J (2010) 431 (2): 311–320.
Published: 28 September 2010
.../ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Akt AMP-activated protein kinase (AMPK) contraction glucose transport skeletal muscle TBC1D1 Skeletal muscle is a major target tissue for insulin...
Includes: Supplementary data
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Biochem J (2006) 399 (3): 473–481.
Published: 13 October 2006
.... In the present study, we compare the effects of palmitoleate (a MUFA) and palmitate (a SFA) on insulin action and glucose utilization in rat L6 skeletal muscle cells. Basal glucose uptake was enhanced approx. 2-fold following treatment of cells with palmitoleate. The MUFA-induced increase in glucose transport...
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Biochem J (2001) 356 (3): 769–777.
Published: 08 June 2001
..., such as stimulation of glucose transport. In the present work, we studied whether these substrates could also mimic long-term actions of insulin. Adipose differentiation of 3T3 F442A cells, which is highly insulin-dependent, served as a model to test the effects of sustained administration of amine oxidase substrates...
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Biochem J (2001) 354 (2): 323–330.
Published: 22 February 2001
... by a trypsin cleavage assay or cell-surface labelling with bis-mannose photolabel, was increased 2.3-fold and 1.6-fold INTRODUCTION Glucose uptake in mammalian cells is mediated by a family of facilitative glucose transporters (GLUT1 6) [1]. GLUT4, the insulin-recruitable isoform, is expressed in adipose...
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Biochem J (2000) 352 (2): 267–276.
Published: 24 November 2000
...Laura M. FLETCHER; Gavin I. WELSH; Paru B. OATEY; Jeremy M. TAVARÉ Insulin stimulates glucose uptake into adipocytes by promoting the translocation of the glucose transporter isoform 4 (GLUT4) from intracellular vesicles to the plasma membrane. In 3T3-L1 adipocytes GLUT4 resides both...
Includes: Supplementary data
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Biochem J (2000) 348 (1): 83–91.
Published: 09 May 2000
...Paul R. PRYOR; Simon C. H. LIU; Avril E. CLARK; Jing YANG; Geoffrey D. HOLMAN; David TOSH Decreases in insulin-responsive glucose transport and associated levels of cell surface GLUT4 occur in rat adipocytes maintained in culture for 20 h under hyperinsulinaemic and hyperglycaemic conditions. We...
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Biochem J (1999) 337 (3): 461–470.
Published: 25 January 1999
... transport. Here, we have examined the effects of transiently expressed wild-type (WT), constitutively active (Constit) and kinase-inactive (KI) forms of atypical PKCs, ζ and λ, on haemagglutinin antigen (HAA)-tagged glucose transporter 4 (GLUT4) translocation in rat adipocytes, and compared these effects...