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Keywords: glucose transport
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Articles
Biochem J (2021) 478 (7): 1315–1319.
Published: 06 April 2021
... (2): 407–422) of complexin-2 as an important contributor to glucose transporter 4 (GLUT4) translocation to muscle cell plasma membrane upon insulin stimulation is essential. The present commentary discusses the biological importance of the findings and proposes future challenges and opportunities...
Articles
Biochem J (2020) 477 (10): 1795–1811.
Published: 21 May 2020
... triphosphate glucose transport glycolysis osteoblasts p53 Oxidative phosphorylation has higher efficiency of ATP production than glycolysis and is the main source of ATP in mammalian cells under aerobic conditions. In cancer cells, however, most glucose is metabolized to lactate even in the...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (19): 2851–2867.
Published: 11 October 2019
... availabilities within their propagated environments. Disruption of the C. burnetii glucose transporter, CBU0265, by transposon mutagenesis led to a significant decrease in [ 13 C]glucose utilization but did not abolish glucose usage, suggesting that C. burnetii express additional hexose transporters which may be...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (18): 2969–2983.
Published: 25 September 2018
... required for maximal activation of AMPK [ 4 ]. T172 phosphorylation can be induced by pharmacological activators of AMPK such as 5-aminoimidazole-4-carboxamide riboside (AICAR), and this is associated with increased glucose uptake [ 5 – 9 ] and translocation of GLUT4 glucose transporters to the plasma...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (10): 1807–1820.
Published: 31 May 2018
... reduced by half in adipocytes from patients with diabetes. To elucidate the effect of reduced FOXO1 activity, we here transduced human adipocytes with a dominant-negative construct of FOXO1 (DN-FOXO1). Inhibition of FOXO1 reduced the abundance of insulin receptor, glucose transporter-4, ribosomal protein...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (2): 219–229.
Published: 08 November 2013
...-like peptides and AGE-1 [ageing alteration 1; orthologue of PI3K (phosphoinositide 3-kinase)], but the identity of the glucose transporters that may link these processes is unknown. We unexpectedly find that of the eight putative GLUT (glucose transporter)-like genes only the two splice variants of one...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (2): 479–489.
Published: 14 December 2012
...Hong Yu Wang; Serge Ducommun; Chao Quan; Bingxian Xie; Min Li; David H. Wasserman; Kei Sakamoto; Carol Mackintosh; Shuai Chen AS160 (Akt substrate of 160 kDa) is a Rab GTPase-activating protein implicated in insulin control of GLUT4 (glucose transporter 4) trafficking. In humans, a truncation...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (3): 587–601.
Published: 16 April 2012
... 1 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell migration glucose transport insulin secretion phosphoinositide phosphoinositide 3-kinase (PI3K) Phosphoinositides are phospholipids comprising two fatty acid chains linked by a glycerol moiety...
Articles
Biochem J (2011) 435 (2): 463–474.
Published: 29 March 2011
... expression} and that this was associated with enhanced phosphorylation/activation of p38 MAPK (mitogen-activated protein kinase), JNK (c-Jun N-terminal kinase) and ERK (extracellular-signal-regulated kinase) as well as impaired insulin-dependent activation of PKB (protein kinase B)/Akt and glucose transport...
Includes: Supplementary data
Articles
Biochem J (2010) 431 (2): 311–320.
Published: 28 September 2010
... kinase (AMPK) contraction glucose transport skeletal muscle TBC1D1 In addition to Akt, there is strong evidence that there are other kinases that can phosphorylate TBC1D1, most notably AMPK. For example, we found that phosphorylation of skeletal muscle TBC1D1 with recombinant AMPK in...
Includes: Supplementary data
Articles
Biochem J (2006) 399 (3): 473–481.
Published: 13 October 2006
... present study, we compare the effects of palmitoleate (a MUFA) and palmitate (a SFA) on insulin action and glucose utilization in rat L6 skeletal muscle cells. Basal glucose uptake was enhanced approx. 2-fold following treatment of cells with palmitoleate. The MUFA-induced increase in glucose transport...
Articles
Biochem J (2004) 381 (2): 495–501.
Published: 06 July 2004
... (e-mail conchagrabinger@uach.cl ). 22 10 2003 9 2 2004 12 3 2004 12 3 2004 The Biochemical Society, London 2004 glucose transport HL-60 cells interleukin-3 receptor interleukin-5 receptor spermatozoa IL (interleukin)-3, IL-5 and GM-CSF (granulocyte...
Articles
Biochem J (2003) 376 (1): 123–134.
Published: 15 November 2003
...@csiro.au ). 16 1 2003 24 7 2003 13 8 2003 13 8 2003 The Biochemical Society, London ©2003 2003 glucose transport GLUT4 insulin action insulin receptor SH3PX1 sorting nexin 9 (SNX9) Abbreviations used: DMEM, Dulbecco's modified Eagle's medium; EGF, epidermal...
Articles
Biochem J (2002) 362 (2): 413–422.
Published: 22 February 2002
...Evgenia ALPERT; Arie GRUZMAN; Hanan TOTARY; Nurit KAISER; Reuven REICH; Shlomo SASSON Bovine aortic endothelial and smooth-muscle cells down-regulate the rate of glucose transport in the face of hyperglycaemia, thus providing protection against deleterious effects of increased intracellular glucose...
Articles
Biochem J (2001) 356 (3): 769–777.
Published: 08 June 2001
... stimulation of glucose transport. In the present work, we studied whether these substrates could also mimic long-term actions of insulin. Adipose differentiation of 3T3 F442A cells, which is highly insulin-dependent, served as a model to test the effects of sustained administration of amine oxidase substrates...
Articles
Biochem J (2001) 356 (1): 143–149.
Published: 08 May 2001
... 2001 The Biochemical Society, London ©2001 2001 adipocyte glucose transport hyperosmolarity insulin signalling zinc Abbreviations used: Rab4 ΔCT, prenylation-deficient, cytosolic form of Rab4; PKB, protein kinase B; PI3-kinase, phosphatidylinositol 3-kinase; KRBH, Krebs–Ringer...
Articles
Biochem J (2001) 354 (2): 323–330.
Published: 22 February 2001
.... adenosine exocytosis glucose transport insulin 1 To whom correspondence should be addressed (e-mail len2@po.cwru.edu ). 28 6 2000 6 11 2000 12 12 2000 The Biochemical Society, London © 2001 2001 Biochem. J. (2001) 354, 323 330 (Printed in Great Britain) 323 GLUT4...
Articles
Biochem J (2000) 352 (2): 267–276.
Published: 24 November 2000
...Laura M. FLETCHER; Gavin I. WELSH; Paru B. OATEY; Jeremy M. TAVARÉ Insulin stimulates glucose uptake into adipocytes by promoting the translocation of the glucose transporter isoform 4 (GLUT4) from intracellular vesicles to the plasma membrane. In 3T3-L1 adipocytes GLUT4 resides both in an...
Includes: Supplementary data
Articles
Biochem J (2000) 350 (1): 171–180.
Published: 09 August 2000
... markedly stimulates glucose transport in rat adipocytes by a mechanism that requires semicarbazide-sensitive amine oxidase (SSAO) activity and H 2 O 2 formation. Here we have further analysed the insulin-like effects of the combination of SSAO substrates and vanadate and we have studied the signal...
Articles
Biochem J (2000) 348 (1): 83–91.
Published: 09 May 2000
...Paul R. PRYOR; Simon C. H. LIU; Avril E. CLARK; Jing YANG; Geoffrey D. HOLMAN; David TOSH Decreases in insulin-responsive glucose transport and associated levels of cell surface GLUT4 occur in rat adipocytes maintained in culture for 20 h under hyperinsulinaemic and hyperglycaemic conditions. We...
Articles
Biochem J (1999) 344 (2): 535–543.
Published: 24 November 1999
...Kate A. POWELL; Lachlan C. CAMPBELL; Jeremy M. TAVARÉ; David P. LEADER; Jill A. WAKEFIELD; Gwyn W. GOULD Insulin stimulates glucose transport in adipose and muscle tissue by stimulating the movement (‘translocation’) of an intracellular pool of glucose transporters (the Glut4 isoform) to the plasma...
Articles
Biochem J (1999) 344 (2): 511–518.
Published: 24 November 1999
...(3,4,5) P 3 than PDGF. ARNO and GRP1 are nucleotide exchange factors for the small GTP-binding protein ADP-ribosylation factor 6 (ARF6). The inability of a constitutively active GTPase-deficient mutant of ARF6 (ARF6-Q67L; Gln 67 → Leu) to cause glucose transporter GLUT4 translocation suggests that...
Includes: Supplementary data
Articles
Biochem J (1999) 343 (1): 151–157.
Published: 24 September 1999
...Otto WALAAS; Robert S. HORN; S. Ivar WALAAS A variety of studies indicate that protein kinase C might be involved in the insulin signalling cascade leading to translocation of the insulin-regulated glucose transporter GLUT4 from intracellular pools to the plasma membrane. Phospholemman is a plasma...
Articles
Biochem J (1999) 338 (3): 737–743.
Published: 08 March 1999
... cytokine differentiation gene expression glucose transport transcription factor Biochem. J. (1999) 338, 737 743 (Printed in Great Britain) 737 Tumour necrosis factor-a regulates expression of the CCAAT-enhancer- binding proteins (C/EBPs) a and b and determines the occupation of the C/EBP site in the...
Articles
Biochem J (1999) 337 (3): 461–470.
Published: 25 January 1999
... transport. Here, we have examined the effects of transiently expressed wild-type (WT), constitutively active (Constit) and kinase-inactive (KI) forms of atypical PKCs, ζ and λ, on haemagglutinin antigen (HAA)-tagged glucose transporter 4 (GLUT4) translocation in rat adipocytes, and compared these effects...