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Zongdong Li, Natasha M. Nesbitt, Lisa E. Malone, Dimitri V. Gnatenko, Song Wu, Daifeng Wang, Wei Zhu, Geoffrey D. Girnun, Wadie F. Bahou
Biochem J (2018) 475 (6): 1211–1223.
Published: 29 March 2018
... (glucose/glutamine) availability and mitochondrial function to balance tricarboxylic acid (TCA)-derived anabolic and redox-regulated antioxidant functions. Heme synthesis and degradation converge in a linear pathway that utilizes TCA cycle-derived carbon in cataplerotic reactions of tetrapyrrole...
Includes: Supplementary data
Biochem J (2016) 473 (22): 4227–4242.
Published: 10 November 2016
...Rugmani Padmanabhan Iyer; Sumin Gu; Jean X. Jiang SNAT1 is a system N/A neutral amino acid transporter that primarily expresses in neurons and mediates the transport of l -glutamine (Gln). Gln is an important amino acid involved in multiple cellular functions and also is a precursor...
Cristina PÉREZ-GÓMEZ, José A. CAMPOS-SANDOVAL, Francisco J. ALONSO, Juan A. SEGURA, Elisa MANZANARES, Pedro RUIZ-SÁNCHEZ, María E. GONZÁLEZ, Javier MÁRQUEZ, José M. MATÉS
Biochem J (2005) 386 (3): 535–542.
Published: 08 March 2005
... These authors contributed equally to this work. 2 To whom correspondence should be addressed (email firstname.lastname@example.org or email@example.com ). 14 6 2004 1 10 2004 21 10 2004 21 10 2004 The Biochemical Society, London 2005 breast cancer cell glutaminase glutamine hepatoma...
Biochem J (2004) 382 (1): 27–32.
Published: 10 August 2004
...Claire I. BUNGARD; John D. McGIVAN Glutamine transport into the human hepatoma cell line HepG2 is catalysed primarily by an ASCT2-type transporter identical in sequence with that cloned previously from JAR cells. An antibody raised against the C-terminus of the ASCT2 protein was shown to recognize...
Cristina PÉREZ-GÓMEZ, José M. MATÉS, Pedro M. GÓMEZ-FABRE, Antonio del CASTILLO-OLIVARES, Francisco J. ALONSO, Javier MÁRQUEZ
Biochem J (2003) 370 (3): 771–784.
Published: 15 March 2003
... Society, London ©2003 2003 breast cancer cells gene regulation glutamine hepatoma cancer cells promoter analysis Abbreviations used: C/EBP, CAAT-enhancer binding protein; CREB, cAMP-responsive element binding protein; EMSA, electrophoretic mobility-shift assay; ER, oestrogen receptor...
Biochem J (2003) 370 (2): 403–408.
Published: 01 March 2003
...Abigail TURNER; John D. McGIVAN This paper describes some properties of glutamine oxidation and glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas. The slow-growing adenoma-derived cell line AA/C1, and the rapidly proliferating carcinoma cell line...
Biochem J (2002) 364 (1): 309–315.
Published: 08 May 2002
...Michael GUPPY; Peter LEEDMAN; XinLin ZU; Victoria RUSSELL For the past 70 years the dominant perception of cancer metabolism has been that it is fuelled mainly by glucose (via aerobic glycolysis) and glutamine. Consequently, investigations into the diagnosis, treatment and the basic metabolism...
Biochem J (2001) 358 (1): 59–67.
Published: 08 August 2001
... leukaemia cell lines, illustrate that several other adaptive processes occur to provide sufficient amounts of the AS substrates, aspartate and glutamine, required to support this increased enzymic activity. In both cell populations, aspartate is derived almost exclusively from intracellular sources, whereas...
Biochem J (2001) 357 (1): 321–328.
Published: 25 June 2001
.... These in itro results parallel the clinical observation # 2001 Biochemical Society 325Asparagine synthetase induces L-asparaginase resistance Figure 4 Comparison of AS mRNA induction following ASNase treatment or glutamine and/or asparagine deprivation of MOLT-4 cells To assess the impact of deprivation...
Biochem J (2000) 349 (2): 501–507.
Published: 10 July 2000
... exception is that the aspartic residue in these signature sequences is replaced by a glutamine residue. In order to identify amino acid residues essential for enzyme activity, a series of site-directed mutagenesis studies and steady-state kinetic experiments were performed. Gln 195 , Ser 199 , Cys 207...
Pedro M. GÓMEZ-FABRE, Juan C. ALEDO, Antonio DEL CASTILLO-OLIVARES, Francisco J. ALONSO, Ignacio NÚÑEZ DE CASTRO, José A. CAMPOS, Javier MÁRQUEZ
Biochem J (2000) 345 (2): 365–375.
Published: 10 January 2000
... and AF110331. 4 6 1999 23 9 1999 5 11 1999 The Biochemical Society, London © 2000 2000 cDNA glutamine isoenzymes, mitochondria tumour Biochem. J. (2000) 345, 365 375 (Printed in Great Britain) 365 Molecular cloning, sequencing and expression studies of the human breast...
Biochem J (2000) 345 (2): 345–350.
Published: 10 January 2000
... in configuration of the Gln residues of P. gingivalis SOD partially accounts for the metal-specific activity of the enzyme. 1 To whom correspondence should be addressed (e-mail yamakura@;sakura.juntendo.ac.jp). 5 10 1999 8 11 1999 The Biochemical Society, London © 2000 2000 glutamine...
Biochem J (1999) 341 (1): 225–231.
Published: 24 June 1999
...) cultured in a nutrient- and serum-deprived medium. The addition of glutamine alone to LLC-PK1 cells cultured in Earl's balanced salt solution (EBSS) is sufficient to suppress gadd153 mRNA expression, and the removal of only glutamine from Dulbecco's modified Eagle's medium (DMEM) is also sufficient...