.... The observed movement phenotype may be caused by reduced densities of PV+/ Gad67 (glutamic acid decarboxylase 67)+ GABAergic and ChAT (choline acetyltransferase)+ cholinergic neurons in the striatum. cholinergic glutathione peroxidase neurodegeneration parvalbumin redox selenium SePs...

...Benjamin Selles; Martin Hugo; Madia Trujillo; Vaibhav Srivastava; Gunnar Wingsle; Jean-Pierre Jacquot; Rafael Radi; Nicolas Rouhier Gpxs (glutathione peroxidases) constitute a family of peroxidases, including selenocysteine- or cysteine-containing isoforms (SeCys-Gpx or Cys-Gpx), which...

... cellular protective enzymes such as GPx (glutathione peroxidase) and TrxR (thioredoxin reductase). Stopped-flow kinetic studies indicate that seleno-compounds react rapidly with HOSCN with rate constants, k , in the range 2.8×10 3 –5.8×10 6 M −1 ·s −1 (for selenomethionine and selenocystamine respectively...

...Magnus S. Alphey; Janine König; Alan H. Fairlamb Tb TDPX ( Trypanosoma brucei tryparedoxin-dependent peroxidase) is a genetically validated drug target in the fight against African sleeping sickness. Despite its similarity to members of the GPX (glutathione peroxidase) family, Tb TDPX2...

... be addressed (email [email protected] ). 28 8 2007 24 10 2007 26 10 2007 26 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 brain fertility glutathione peroxidase nutrition selenium thioredoxin reductase Fifty years ago...

... was to determine impacts of knockout of SOD1 (superoxide dismutase; Cu,Zn-SOD) alone or in combination with selenium-dependent GPX1 (glutathione peroxidase-1) on APAP-induced hepatotoxicity. All SOD1-null (SOD1 −/− ) and SOD1- and GPX1-double-knockout mice survived an intraperitoneal injection of 600 mg of APAP...

...). Their glutaredoxin activity is also detectable in yeast cell extracts. The enzyme activity characteristics of the Gto proteins contrast with those of another yeast GST, Gtt1. The latter is active against CDNB and also displays glutathione peroxidase activity against organic hydroperoxides such as cumene...

... and kidney selenium to decrease to 36% of wild-type levels. Likewise, glutathione peroxidase activities decreased in plasma and kidney to 43% and 18% respectively of wild-type levels. This agrees nicely with data from SePP knockout mice, supporting a selenium transport role for hepatically expressed SePP...

... sufficiently safe to prevent overdosages. Key words: glutathione peroxidase, growth, lactation, selenium, selenoprotein P, transport. INTRODUCTION Selenium (Se) is an essential trace element that is required for normal growth and development [1 3]. It is present in the rare amino acid selenocysteine (Sec...

... HepG2 cells, a human hepatocellular carcinoma-derived line. MnSOD activity increased 5–7-fold during incubation in a medium supplemented with metal-depleted fetal bovine serum, with a corresponding elevation of its mRNA levels. Metal depletion also decreased CuZnSOD and glutathione peroxidase levels...

... after treatment of cells. Pre-treatment of CGNs and neuroblastoma cells with the metalloporphyrin antioxidant enzyme mimic, Fe(III)tetrakis(4-benzoic acid)porphyrin (FeTBAP), completely prevented the MPP + -induced caspase 3 activity as did overexpression of glutathione peroxidase (GPx1) and pre...

..., but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues. glutathione peroxidase selenium...

... with the accession number AF108213. 30 11 1998 1 3 1999 23 3 1999 The Biochemical Society, London © 1999 1999 glutathione peroxidase redox regulation selenium Biochem. J. (1999) 340, 439 444 (Printed in Great Britain) 439 Functional expression of rat thioredoxin reductase...