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Keywords: glycosaminoglycan (GAG)
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Articles

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

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Prem Raj B. Joseph, Philip D. Mosier, Umesh R. Desai, Krishna Rajarathnam
Journal: Biochemical Journal
Biochem J (2015) 472 (1): 121–133.
https://doi.org/10.1042/BJ20150059
Published: 30 October 2015
... and interaction of both forms with glycosaminoglycans (GAGs) mediate these diverse cellular processes. However, very little is known regarding the structural basis underlying CXCL8–GAG interactions. There are conflicting reports on the affinities, geometry and whether the monomer or dimer is the high-affinity GAG...
View articletitled, Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions
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Includes: Supplementary data
Articles

Zymogen activation of neurotrypsin and neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans

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Claudio Gisler, Daniel Lüscher, Philipp Schätzle, Stephanie Dürr, Antonio Baici, Giovanna Galliciotti, Raymond Reif, Marc F. Bolliger, Beat Kunz, Peter Sonderegger
Journal: Biochemical Journal
Biochem J (2013) 453 (1): 83–100.
https://doi.org/10.1042/BJ20130166
Published: 13 June 2013
... compilation © 2013 Biochemical Society 2013 agrin glycosaminoglycan (GAG) neurotrypsin proprotein convertase proteolysis zymogen activation The synaptic serine peptidase neurotrypsin plays an important role in higher brain functions, as humans with a defect in neurotrypsin exhibit severe...
View articletitled, Zymogen activation of neurotrypsin and neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans
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Includes: Supplementary data
Articles

Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1

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Thomas A. Murray-Rust, Felicity K. Kerr, Adele R. Thomas, Tina Wu, Tang Yongqing, Poh Chee Ong, Noelene S. Quinsey, James C. Whisstock, Ineke C. Wagenaar-Bos, Craig Freeman, Robert N. Pike
Journal: Biochemical Journal
Biochem J (2009) 422 (2): 295–303.
https://doi.org/10.1042/BJ20090198
Published: 13 August 2009
... to this work. 2 To whom correspondence should be addressed (email [email protected] ). 3 2 2009 8 6 2009 12 6 2009 12 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 C1 inhibitor complement glycosaminoglycan (GAG) protease SERPING1...
View articletitled, Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1
Open the PDF for Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1 in another window
Includes: Supplementary data
Articles

Thermodynamic insights into the structural basis governing the donor substrate recognition by human β1,4-galactosyltransferase 7

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Franck Daligault, Sophie Rahuel-Clermont, Sandrine Gulberti, Manh-Thong Cung, Guy Branlant, Patrick Netter, Jacques Magdalou, Virginie Lattard
Journal: Biochemical Journal
Biochem J (2009) 418 (3): 605–614.
https://doi.org/10.1042/BJ20081093
Published: 25 February 2009
...-GalT) glycosaminoglycan (GAG) isothermal titration calorimetry (ITC) kinetics substrate recognition substrate specificity Human β1,4-GalT (galactosyltransferase)7 (EC 2.4.1.133, family GT7 in CAZy database, http://www.cazy.org ) is a Golgi-resident type II membrane protein that catalyses...
View articletitled, Thermodynamic insights into the structural basis governing the donor substrate recognition by human β1,4-galactosyltransferase 7
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Includes: Supplementary data
Articles

Intracellular proteoglycans

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Svein Olav KOLSET, Kristian PRYDZ, Gunnar PEJLER
Journal: Biochemical Journal
Biochem J (2004) 379 (2): 217–227.
https://doi.org/10.1042/bj20031230
Published: 15 April 2004
... be addressed (e-mail [email protected] ). 13 8 2003 23 12 2003 3 2 2004 3 2 2004 The Biochemical Society, London ©2004 2004 glycosaminoglycan (GAG) protease proteoglycan (PG) serglycin Abbreviations used: ChSy, chondroitin sulphate polymerase; GAG...
View articletitled, Intracellular proteoglycans
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Articles

Cell-surface prion protein interacts with glycosaminoglycans

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Tao PAN, Boon-Seng WONG, Tong LIU, Ruliang LI, Robert B. PETERSEN, Man-Sun SY
Journal: Biochemical Journal
Biochem J (2002) 368 (1): 81–90.
https://doi.org/10.1042/bj20020773
Published: 15 November 2002
...Tao PAN; Boon-Seng WONG; Tong LIU; Ruliang LI; Robert B. PETERSEN; Man-Sun SY We used ELISA and flow cytometry to study the binding of prion protein PrP to glycosaminoglycans (GAGs). We found that recombinant human PrP (rPrP) binds GAGs including chondroitin sulphate A, chondroitin sulphate B...
View articletitled, Cell-surface prion protein interacts with glycosaminoglycans
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