...Alexandra Coomans de Brachène; Emeline Bollaert; Astrid Eijkelenboom; Audrey de Rocca Serra; Kristan E. van der Vos; Boudewijn M. T. Burgering; Paul J. Coffer; Ahmed Essaghir; Jean-Baptiste Demoulin Growth factors inactivate the FOXO (forkhead box O) transcription factors through PI3K...

...Joshua K. Salabei; Timothy D. Cummins; Mahavir Singh; Steven P. Jones; Aruni Bhatnagar; Bradford G. Hill Vascular injury and chronic arterial diseases result in exposure of VSMCs (vascular smooth muscle cells) to increased concentrations of growth factors. The mechanisms by which growth factors...

...Raissa Perrault; Peter Zahradka Vascular dysfunction is the underlying cause of nearly 80% of heart disease cases, and its initiation and progression can be exacerbated by circulating factors, such as IGF-1 (insulin-like growth factor 1). IGF-1, which is highly homologous with insulin, elicits...

...Murat Cirit; Jason M. Haugh Signal transduction networks in mammalian cells, comprising a limited set of interacting biochemical pathways, are accessed by various growth factor and cytokine receptors to elicit distinct cell responses. This raises the question as to how specificity of the stimulus...

... that regulate Glut1 trafficking, however, are not certain. In the present study, we show that a C-terminal PDZ-binding motif in Glut1 is critical to promote maximal cytokine-stimulated Glut1 cell surface localization and prevent Glut1 lysosomal degradation in the absence of growth factor. Disruption of this PDZ...

...-derived growth factor)-BB and other growth factors. Human dermal fibroblasts exhibited the highest hyaluronan-synthesizing activity in response to PDGF-BB. Analysis of HAS (hyaluronan synthase) and HYAL (hyaluronidase) mRNA expression showed that PDGF-BB treatment induced a 3-fold increase in the already...

.... Since FoxO6 can be considered constitutively nuclear, we investigated whether it is also a constitutively active transcription factor. Our results show that FoxO6 transcriptional activity is inhibited by growth factors, independent of shuttling, indicating that it is not constitutively active. The PKB...

... cells are activated. In the present study, we report that ADA2 is a heparin-binding protein. This allowed us to obtain a highly purified enzyme and to study its biochemistry. ADA2 was identified as a member of a new class of ADGFs (ADA-related growth factors), which is present in almost all organisms...

...Paula E. Row; Michael J. Clague; Sylvie Urbé Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (signal-transducing adaptor molecule) form a heterodimeric complex that associates with endosomal membranes and is tyrosine-phosphorylated in response to a variety of growth...

...Pedro P. JUANES; Laura FERREIRA; Juan Carlos MONTERO; Joaquín ARRIBAS; Atanasio PANDIELLA ProTGFα (transforming growth factor α precursor) maturation and conversion into soluble TGFα is a complex process that involves three proteolytic steps. One, that occurs co-translationally, eliminates...

...Peter CLAUS; Alexander-Francisco BRUNS; Claudia GROTHE The SMN (survival of motoneuron) protein is mutated in patients with the neurodegenerative disease spinal muscular atrophy. We have shown previously that a high-molecular-mass isoform of FGF (fibroblast growth factor) 2 (FGF-2 23...

... in the absence of growth factors by down-regulating ERK (extracellular-signal-regulated kinase), up-regulating JNK (c-Jun N-terminal kinase) and p38 MAPK (mitogen-activated protein kinase) pathways, and affecting their downstream effectors. SARS-CoV N expression also down-regulated phospho-Akt and Bcl-2 levels...

... 15 4 2004 26 4 2004 The Biochemical Society, London 2004 gastric epithelium growth factor Reg-1 RhoA Sp1/3 transcription The epithelium of the gastrointestinal tract exhibits a range of adaptive responses to infection, inflammation and damage, as well as to delivery...

... and renal hypertrophy. Our previous studies have found that high glucose does not induce cellular hypertrophy or expression of TGF-β1 (transforming growth factor-β1) in distal renal tubule cells [Yang, Guh, Yang, Lai, Tsai, Hung, Chang and Chuang (1998) J. Am. Soc. Nephrol. 9 , 182–193]. In the present...

...Xiangshan ZHAO; Lixia GAN; Haiyun PAN; Donghui KAN; Michael MAJESKI; Stephen A. ADAM; Terry G. UNTERMAN FOXO1, a Forkhead transcription factor, is an important target of insulin and growth factor action. Phosphorylation of Thr-24, Ser-256 and Ser-319 promotes nuclear exclusion of FOXO1, yet...

...Smitha MATHEW; Sanja ARANDJELOVIC; Wayne F. BEYER; Steven L. GONIAS; Salvatore V. PIZZO Basic fibroblast growth factor (FGF-2) is important in development, wound healing and angiogenesis. The human plasma proteinase inhibitor α 2 -macroglobulin (α 2 M) binds to and regulates the biological activity...

...-dependent growth stimulation was observed when each of the fibroblastic cell lines was exposed to HC-gp39 in a concentration range from 0.1 to 2nM, which is similar to the effective dose of the well-characterized mitogen, insulin-like growth factor-1. At suboptimal concentrations, the two growth factors...

...Diana ENSENAT; Saamir HASSAN; Sylvia V. REYNA; Andrew I. SCHAFER; William DURANTE Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that contributes to arterial remodelling by stimulating vascular smooth muscle cell (SMC) growth and collagen synthesis at sites of vascular injury...

... with platelet-derived growth factor B-chain homodimer (PDGF-BB) also enhanced the BK-induced Ins(X) P response. These enhancements by IL-1β and PDGF-BB might be due to an up-regulation of BK B 2 receptor density ( B max ), since [ 3 H]BK binding to TSMCs was inhibited by the B 2 -selective agonist...

..., including insulin-stimulated glucose uptake. Platelet-derived growth factor (PDGF) also stimulates PI 3-kinase, but only weakly promotes glucose uptake when compared with insulin. Insulin and PDGF have thus been proposed to have differential effects on the subcellular targeting of PI 3-kinase. However...

... differentiation factor. 1 To whom correspondence should be addressed (e-mail [email protected] ). 15 2 1999 18 6 1999 27 7 1999 The Biochemical Society, London © 1999 1999 Dictyostelium differentiation growth factor Biochem. J. (1999) 343, 265 271 (Printed in Great...

.... It also permits the direct analysis of the effects of surface-bound cytokines on target cells. growth factor haemopoiesis steel factor Biochem. J. (1999) 339, 429 434 (Printed in Great Britain) 429 Cellulose as an inert matrix for presenting cytokines to target cells : production and properties...