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Keywords: growth factor cystine knot (GFCK)
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Articles

Structural characterisation of a cysteine-rich conotoxin, sigma(σ)S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus

Open Access
Yoshimi Peck, David T. Wilson, Danica Lennox-Bulow, Julien Giribaldi, Jamie Seymour, Sebastien Dutertre, K. Johan Rosengren, Michael J. Liddell, Norelle L. Daly
Journal: Biochemical Journal
Biochem J (2025) 482 (11): 639–653.
https://doi.org/10.1042/BCJ20240753
Published: 23 May 2025
... involved in five disulfide bonds. Using NMR spectroscopy, we show that σS-GVIIIA adopts a growth factor cystine knot (GFCK) fold. This is the first example of a cone snail venom peptide experimentally determined to contain the GFCK structural motif and the first example of a 5-HT 3 receptor antagonist...
View articletitled, Structural characterisation of a cysteine-rich conotoxin, sigma(σ)S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus
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Includes: Supplementary data