...Lorenza A. D’Alessandro; Ursula Klingmüller; Marcel Schilling In health and disease, liver cells are continuously exposed to cytokines and growth factors. While individual signal transduction pathways induced by these factors were studied in great detail, the cellular responses induced by repeated...

...Chantal STHENEUR; Marie-France DUMONTIER; Claudie GUEDES; Marie-Claude FULCHIGNONI-LATAUD; Khadija TAHIRI; Gerard KARSENTY; Marie Thérèse CORVOL Matrix Gla protein (MGP) is a member of the vitamin K-dependent γ carboxylase protein family expressed in cartilage. Insulin-like growth factor I (IGF1...

... by the extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and the p38 mitogen-activated protein kinase (MAPK) routes. In the present paper, we show that shedding of membrane-anchored growth factors (MAGFs) may also occur through MAPK-independent routes. In Chinese-hamster ovary cells, cleavage induced...

...Nadia ABDEL-WAHAB; Stephen J. WICKS; Roger M. MASON; Andrew CHANTRY Transforming growth factor-β (TGFβ) is a key mediator of extracellular matrix (ECM) accumulation in sclerotic kidney diseases such as diabetic nephropathy. One of the main target cells for TGFβ in the kidney are glomerular...

... 7 2000 10 11 2000 19 12 2000 The Biochemical Society, London © 2001 2001 chromatography growth factors matrix Biochem. J. (2001) 354, 447 453 (Printed in Great Britain) 447 Aggregation-independent modulation of proteoglycan binding by neutralization of C-terminal acidic...

...Maribeth M. WERT; H. Clive PALFREY The mechanisms whereby nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) block apoptosis in serum-deprived PC12 cells were investigated. NGF, but not bFGF, strongly activated Akt/protein kinase B, a downstream effector of phosphoinositide...

.... The expression of the transcripts was higher in subconfluent than in confluent cultures and was well correlated with the production of hyaluronan by the cells. Stimulation of mesothelial cells with platelet-derived growth factor-BB induced an up-regulation of mRNA for HAS2 to a maximum after 6 h of stimulation...

... with growth factors such as erythropoietin, interleukin 3 and granulocyte}macrophage colony-stimulating factor (GM-CSF) (reviewed in [1,2 The receptor for SCF is a product of the kit proto-oncogene. c-Kit has intrinsic protein tyrosine kinase activity and is related to the receptors for platelet-derived...