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Keywords: guanine-nucleotide-exchange factor
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Articles

Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

Muayad Almahariq, Fang C. Mei, Hui Wang, Anthony T. Cao, Suxia Yao, Lynn Soong, Jiaren Sun, Yingzi Cong, Ju Chen, Xiaodong Cheng
Journal: Biochemical Journal
Biochem J (2015) 465 (2): 295–303.
https://doi.org/10.1042/BJ20140952
Published: 06 January 2015
... 2015 Biochemical Society 2015 cAMP EPAC1 gap junction guanine-nucleotide-exchange factor regulatory T-cell STAT3 TGF-β1 Regulatory T-cells (Tregs) are T-lymphocytes that possess a general suppressor function and play an essential role in both adaptive and innate immunity [ 1 , 2...
View articletitled, Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression
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Includes: Supplementary data
Articles

The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42

Abhishek Upadhyay, Huan-Lin Wu, Christopher Williams, Terry Field, Edouard E. Galyov, Jean M. H. van den Elsen, Stefan Bagby
Journal: Biochemical Journal
Biochem J (2008) 411 (3): 485–493.
https://doi.org/10.1042/BJ20071546
Published: 14 April 2008
... Society 2008 bacterial pathogen guanine-nucleotide-exchange factor protein–protein interaction protein structure Rho GTPase type III secretion Burkholderia pseudomallei is a Gram-negative bacterium that is the aetiological agent of melioidosis, a severe emerging infection of humans...
View articletitled, The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42
Open the PDF for The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42 in another window
Includes: Supplementary data
Articles

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Ian N. FLEMING, Ian H. BATTY, Alan R. PRESCOTT, Alex GRAY, Gursant S. KULAR, Hazel STEWART, C. Peter DOWNES
Journal: Biochemical Journal
Biochem J (2004) 382 (3): 857–865.
https://doi.org/10.1042/BJ20040916
Published: 07 September 2004
...Ian N. FLEMING; Ian H. BATTY; Alan R. PRESCOTT; Alex GRAY; Gursant S. KULAR; Hazel STEWART; C. Peter DOWNES Binding of the Rac1-specific guanine-nucleotide-exchange factor, Tiam1, to the plasma membrane requires the N-terminal pleckstrin homology domain. In the present study, we show that membrane...
View articletitled, Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1
Open the PDF for Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1 in another window