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Keywords: haemoglobin
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Biochem J (2014) 458 (3): e5–e7.
Published: 28 February 2014
... still requires specific validation. Finally, given the well-known function of 23BPG as a negative allosteric effector of haemoglobin [ 11 ], it would be reasonable to speculate the possible role of TIGAR in regulating oxygen binding to haemoglobin. Gerin et al. [ 7 ] discarded this possibility in...
Biochem J (2012) 446 (3): 499–508.
Published: 28 August 2012
...@uab.edu ). 24 4 2012 15 6 2012 21 6 2012 21 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 haemoglobin inflammation kinetics nitric oxide nitrite vasoconstriction Transfusion with RBCs (red blood cells) is the front-line therapy for...
Includes: Supplementary data
Biochem J (2012) 441 (3): 843–852.
Published: 16 January 2012
...María T. Marcos-Almaraz; José A. Rodríguez-Gómez; José López-Barneo; Alberto Pascual Discovery of haemoglobin A expression outside of the erythroid cell lineage suggests that oxygen transport is the main, but not the unique, function of adult haemoglobin chains in mammals. The contribution of...
Includes: Supplementary data
Biochem J (2011) 434 (3): 483–492.
Published: 24 February 2011
...Brandon J. Reeder; Dimitri A. Svistunenko; Michael T. Wilson Cytoglobin is a recently discovered hexa-co-ordinate haemoglobin that does not appear to function as a classical oxygen-binding protein. Its function is unknown and studies on the effects of changes in its expression have not decisively...
Includes: Supplementary data
Biochem J (2010) 432 (1): 145–151.
Published: 25 October 2010
...Louay Mardini; Jadwiga Gasiorek; Anna Derjuga; Lucie Carrière; Matthias Schranzhofer; Barry H. Paw; Prem Ponka; Volker Blank Late-stage erythroid cells synthesize large quantities of haemoglobin, a process requiring the co-ordinated regulation of globin and haem synthesis as well as iron uptake. In...
Biochem J (2010) 425 (1): 257–264.
Published: 14 December 2009
...Dominic P. Byrne; Katarzyna Wawrzonek; Anna Jaworska; Andrew J. Birss; Jan Potempa; John W. Smalley The Gram-negative oral anaerobe Prevotella intermedia forms an iron(III) protoporphyrin IX pigment from haemoglobin. The bacterium expresses a 90 kDa cysteine protease, InpA (interpain A), a...
Biochem J (2007) 403 (3): 391–395.
Published: 12 April 2007
...Radu Silaghi-Dumitrescu; Brandon J. Reeder; Peter Nicholls; Chris E. Cooper; Michael T. Wilson Ferryl (Fe(IV)=O) species are involved in key enzymatic processes with direct biomedical relevance; among others, the uncontrolled reactivities of ferryl Mb (myoglobin) and Hb (haemoglobin) have been...
Biochem J (2007) 402 (1): 143–151.
Published: 25 January 2007
...Tao Hu; Belur N. Manjula; Dongxia Li; Michael Brenowitz; Seetharama A. Acharya The influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated {PEG [poly(ethylene glycol)]-conjugated} haemoglobin has been investigated. The sites and the extent of...
Biochem J (2006) 399 (3): 513–524.
Published: 13 October 2006
...Jacqueline Dunne; Alexis Caron; Patrick Menu; Abdu I. Alayash; Paul W. Buehler; Michael T. Wilson; Radu Silaghi-Dumitrescu; Beatrice Faivre; Chris E. Cooper Haemoglobin initiates free radical chemistry. In particular, the interactions of peroxides with the ferric (met) species of haemoglobin...
Biochem J (2005) 389 (2): 297–306.
Published: 05 July 2005
... the oxygen-transport haem protein from the Antarctic skate Bathyraja eatonii and from the Arctic skate Raja hyperborea (both of the subclass Elasmobranchii, order Rajiformes, family Rajidae) is reported in the present paper. These species have a single major haemoglobin (Hb 1; over 80% of the total...
Biochem J (2005) 385 (2): 409–418.
Published: 07 January 2005
... ). 9 7 2004 26 8 2004 10 9 2004 10 9 2004 The Biochemical Society, London 2005 artemisinin haemoglobin haemozoin Plasmodium falciparum histidine-rich protein II (PfHRP II) redox activity Malaria, one of the commonest diseases in tropical countries, is...
Biochem J (2004) 384 (2): 367–375.
Published: 23 November 2004
...Yiping JIA; Somasundaram RAMASAMY; Francine WOOD; Abdu I. ALAYASH; Joseph M. RIFKIND O -R-polyHbA 0 is an intra- and intermolecularly O -raffinose cross-linked derivative of deoxygenated human haemoglobin developed as an oxygen therapeutic. When compared with its native protein (HbA 0 ), O -R...
Biochem J (2004) 382 (1): 183–189.
Published: 10 August 2004
...Kim D. VANDEGRIFF; Andrea BELLELLI; Michele SAMAJA; Ashok MALAVALLI; Maurizio BRUNORI; Robert M. WINSLOW The hypertensive effect observed with most cell-free haemoglobins has been proposed to result from NO scavenging. However, a newly developed PEG [poly(ethylene glycol)]-conjugated haemoglobin...
Biochem J (2004) 380 (3): 889–896.
Published: 15 June 2004
...M. Cristina DE ROSA; Massimo CASTAGNOLA; Claudia BERTONATI; Antonio GALTIERI; Bruno GIARDINA Haemoglobins from mammals of sub-Arctic and Arctic species, as well as fetal human Hb, are all characterized by a significantly lower Δ H of oxygenation compared with the majority of mammalian haemoglobins...
Biochem J (2004) 379 (3): 833–840.
Published: 01 May 2004
... generated a haemoglobin haemichrome. Inhibition of Arg-X protease activity of W50, W501, D7 and K1A with leupeptin, under conditions where Lys-X protease activity was unaffected, prevented the production of µ-oxo bishaem from oxyhaemoglobin, but resulted in the formation of a haemoglobin haemichrome. These...
Biochem J (2004) 378 (2): 529–538.
Published: 01 March 2004
...Byoung-Kuk NA; Bhaskar R. SHENAI; Puran S. SIJWALI; Youngchool CHOE; Kailash C. PANDEY; Ajay SINGH; Charles S. CRAIK; Philip J. ROSENTHAL Cysteine proteases play important roles in the life cycles of malaria parasites. Cysteine protease inhibitors block haemoglobin hydrolysis and development in...
Biochem J (2003) 375 (1): 33–40.
Published: 01 October 2003
... inflammatory tissue injury. 1 To whom correspondence should be addressed (e-mail christine.winterbourn@chmeds.ac.nz ). 9 5 2003 30 6 2003 9 7 2003 9 7 2003 The Biochemical Society, London ©2003 2003 haemoglobin myeloperoxidase myoglobin neutrophil protein aggregation...
Biochem J (2003) 372 (3): 679–686.
Published: 15 June 2003
...Mariagiuseppina PELLEGRINI; Bruno GIARDINA; Cinzia VERDE; Vito CARRATORE; Alessandra OLIANAS; Luigi SOLLAI; Maria T. SANNA; Massimo CASTAGNOLA; Guido di PRISCO The Conger conger (conger eel) haemoglobin (Hb) system is made of three components, one of which, the so-called cathodic Hb, representing...
Biochem J (2002) 368 (1): 273–281.
Published: 15 November 2002
... with P2 Leu and ready hydrolysis of haemoglobin. However, key differences between the plasmodial proteases were identified. In particular, vinckepain-2 showed very different kinetics against many substrates and an unusual preference for peptide substrates with P1 Gly. Replacement of Ala 23 with Gly...
Biochem J (2002) 365 (3): 801–808.
Published: 01 August 2002
... removing fructosamine residues from proteins. In the present study, we show that incubation of human erythrocytes with 200mM glucose not only caused the progressive formation of glycated haemoglobin, but also increased the level of an anionic form of haemoglobin containing alkali-labile phosphate, to...
Biochem J (2001) 360 (2): 481–489.
Published: 26 November 2001
...Puran S. SIJWALI; Bhaskar R. SHENAI; Jiri GUT; Ajay SINGH; Philip J. ROSENTHAL In the malaria parasite Plasmodium falciparum , erythrocytic trophozoites hydrolyse haemoglobin to provide amino acids for parasite protein synthesis. Cysteine protease inhibitors block parasite haemoglobin hydrolysis...
Biochem J (2001) 355 (2): 333–338.
Published: 06 April 2001
...Amit V. PANDEY; Himani BISHT; Vinod K. BABBARWAL; Jaya SRIVASTAVA; Kailash C. PANDEY; Virander S. CHAUHAN The haem detoxification pathway of the malaria parasite Plasmodium falciparum is a potential biochemical target for drug development. Free haem, released after haemoglobin degradation, is...
Biochem J (2001) 353 (2): 207–213.
Published: 08 January 2001
... The Biochemical Society, London © 2001 2001 bacterial NO detoxification haemoglobin NO oxygenase Biochem. J. (2001) 353, 207 213 (Printed in Great Britain) 207 Escherichia coli flavohaemoglobin (Hmp) with equistoichiometric FAD and haem contents has a low affinity for dioxygen in the...
Biochem J (1999) 343 (3): 681–685.
Published: 25 October 1999
...Tao ZHENG; Thomas BRITTAIN; Nicholas J. WATMOUGH; Roy E. WEBER The role of the amino acid at position α 38 in haemoglobin has been probed using site-directed mutagenesis. When the Thr residue at position α 38 (which is totally conserved in all mammals) is changed to a Gln, the equilibrium...