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1-24 of 24
Keywords: haemoglobin
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Articles
TIGAR's promiscuity
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2014) 458 (3): e5–e7.
Published: 28 February 2014
...-bisphosphoglycerate phosphatase cancer glycolysis haemoglobin hypoxia mitochondrion oxygen sensing TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] is an important survival factor for cancer cells [ 1 ]. The enzymatic activity supported by sequence analysis led Bensaad et al...
Articles
Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity
Available to PurchaseRyan Stapley, Benjamin Y. Owusu, Angela Brandon, Marianne Cusick, Cilina Rodriguez, Marisa B. Marques, Jeffrey D. Kerby, Scott R. Barnum, Jordan A. Weinberg, Jack R. Lancaster, Jr, Rakesh P. Patel
Journal:
Biochemical Journal
Biochem J (2012) 446 (3): 499–508.
Published: 28 August 2012
... of nitrite salts for the treatment of cardiovascular conditions. 2 To whom correspondence should be addressed (email [email protected] ). 24 4 2012 15 6 2012 21 6 2012 21 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 haemoglobin inflammation...
Includes: Supplementary data
Articles
α-Haemoglobin regulates sympathoadrenal cell metabolism to maintain a catecholaminergic phenotype
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Journal:
Biochemical Journal
Biochem J (2012) 441 (3): 843–852.
Published: 16 January 2012
...María T. Marcos-Almaraz; José A. Rodríguez-Gómez; José López-Barneo; Alberto Pascual Discovery of haemoglobin A expression outside of the erythroid cell lineage suggests that oxygen transport is the main, but not the unique, function of adult haemoglobin chains in mammals. The contribution...
Includes: Supplementary data
Articles
Lipid binding to cytoglobin leads to a change in haem co-ordination: a role for cytoglobin in lipid signalling of oxidative stress
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Journal:
Biochemical Journal
Biochem J (2011) 434 (3): 483–492.
Published: 24 February 2011
...Brandon J. Reeder; Dimitri A. Svistunenko; Michael T. Wilson Cytoglobin is a recently discovered hexa-co-ordinate haemoglobin that does not appear to function as a classical oxygen-binding protein. Its function is unknown and studies on the effects of changes in its expression have not decisively...
Includes: Supplementary data
Articles
Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake 1
Available to PurchaseLouay Mardini, Jadwiga Gasiorek, Anna Derjuga, Lucie Carrière, Matthias Schranzhofer, Barry H. Paw, Prem Ponka, Volker Blank
Journal:
Biochemical Journal
Biochem J (2010) 432 (1): 145–151.
Published: 25 October 2010
...Louay Mardini; Jadwiga Gasiorek; Anna Derjuga; Lucie Carrière; Matthias Schranzhofer; Barry H. Paw; Prem Ponka; Volker Blank Late-stage erythroid cells synthesize large quantities of haemoglobin, a process requiring the co-ordinated regulation of globin and haem synthesis as well as iron uptake...
Articles
Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin
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Journal:
Biochemical Journal
Biochem J (2010) 425 (1): 257–264.
Published: 14 December 2009
...Dominic P. Byrne; Katarzyna Wawrzonek; Anna Jaworska; Andrew J. Birss; Jan Potempa; John W. Smalley The Gram-negative oral anaerobe Prevotella intermedia forms an iron(III) protoporphyrin IX pigment from haemoglobin. The bacterium expresses a 90 kDa cysteine protease, InpA (interpain...
Articles
Ferryl haem protonation gates peroxidatic reactivity in globins
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Journal:
Biochemical Journal
Biochem J (2007) 403 (3): 391–395.
Published: 12 April 2007
...Radu Silaghi-Dumitrescu; Brandon J. Reeder; Peter Nicholls; Chris E. Cooper; Michael T. Wilson Ferryl (Fe(IV)=O) species are involved in key enzymatic processes with direct biomedical relevance; among others, the uncontrolled reactivities of ferryl Mb (myoglobin) and Hb (haemoglobin) have been...
Articles
Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin
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Journal:
Biochemical Journal
Biochem J (2007) 402 (1): 143–151.
Published: 25 January 2007
...Tao Hu; Belur N. Manjula; Dongxia Li; Michael Brenowitz; Seetharama A. Acharya The influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated {PEG [poly(ethylene glycol)]-conjugated} haemoglobin has been investigated. The sites and the extent...
Articles
Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo
Available to PurchaseJacqueline Dunne, Alexis Caron, Patrick Menu, Abdu I. Alayash, Paul W. Buehler, Michael T. Wilson, Radu Silaghi-Dumitrescu, Beatrice Faivre, Chris E. Cooper
Journal:
Biochemical Journal
Biochem J (2006) 399 (3): 513–524.
Published: 13 October 2006
...Jacqueline Dunne; Alexis Caron; Patrick Menu; Abdu I. Alayash; Paul W. Buehler; Michael T. Wilson; Radu Silaghi-Dumitrescu; Beatrice Faivre; Chris E. Cooper Haemoglobin initiates free radical chemistry. In particular, the interactions of peroxides with the ferric (met) species of haemoglobin...
Articles
Structure, function and molecular adaptations of haemoglobins of the polar cartilaginous fish Bathyraja eatonii and Raja hyperborea
Available to PurchaseCinzia Verde, M. Cristina De Rosa, Daniela Giordano, Donato Mosca, Donatella De Pascale, Luca Raiola, Ennio Cocca, Vitale Carratore, Bruno Giardina, Guido Di Prisco
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 297–306.
Published: 05 July 2005
... of the oxygen-transport haem protein from the Antarctic skate Bathyraja eatonii and from the Arctic skate Raja hyperborea (both of the subclass Elasmobranchii, order Rajiformes, family Rajidae) is reported in the present paper. These species have a single major haemoglobin (Hb 1; over 80% of the total...
Articles
Reaction of artemisinin with haemoglobin: implications for antimalarial activity
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Journal:
Biochemical Journal
Biochem J (2005) 385 (2): 409–418.
Published: 07 January 2005
... by a two-pronged effect of stalling the formation of haemozoin by the competitive inhibition of haem binding to its templates and creating a more reducing environment that is not conducive to the formation of haemozoin. artemisinin haemoglobin haemozoin Plasmodium falciparum histidine-rich protein...
Articles
Cross-linking with O -raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation
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Journal:
Biochemical Journal
Biochem J (2004) 384 (2): 367–375.
Published: 23 November 2004
...Yiping JIA; Somasundaram RAMASAMY; Francine WOOD; Abdu I. ALAYASH; Joseph M. RIFKIND O -R-polyHbA 0 is an intra- and intermolecularly O -raffinose cross-linked derivative of deoxygenated human haemoglobin developed as an oxygen therapeutic. When compared with its native protein (HbA 0 ), O -R...
Articles
Kinetics of NO and O 2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin
Available to PurchaseKim D. VANDEGRIFF, Andrea BELLELLI, Michele SAMAJA, Ashok MALAVALLI, Maurizio BRUNORI, Robert M. WINSLOW
Journal:
Biochemical Journal
Biochem J (2004) 382 (1): 183–189.
Published: 10 August 2004
...Kim D. VANDEGRIFF; Andrea BELLELLI; Michele SAMAJA; Ashok MALAVALLI; Maurizio BRUNORI; Robert M. WINSLOW The hypertensive effect observed with most cell-free haemoglobins has been proposed to result from NO scavenging. However, a newly developed PEG [poly(ethylene glycol)]-conjugated haemoglobin...
Articles
From the Arctic to fetal life: physiological importance and structural basis of an additional chloride-binding site in haemoglobin
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Journal:
Biochemical Journal
Biochem J (2004) 380 (3): 889–896.
Published: 15 June 2004
...M. Cristina DE ROSA; Massimo CASTAGNOLA; Claudia BERTONATI; Antonio GALTIERI; Bruno GIARDINA Haemoglobins from mammals of sub-Arctic and Arctic species, as well as fetal human Hb, are all characterized by a significantly lower Δ H of oxygenation compared with the majority of mammalian haemoglobins...
Articles
A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the mu-oxo bishaem-containing pigment from haemoglobin
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Journal:
Biochemical Journal
Biochem J (2004) 379 (3): 833–840.
Published: 01 May 2004
... a haemoglobin haemichrome. Inhibition of Arg-X protease activity of W50, W501, D7 and K1A with leupeptin, under conditions where Lys-X protease activity was unaffected, prevented the production of µ-oxo bishaem from oxyhaemoglobin, but resulted in the formation of a haemoglobin haemichrome. These results show...
Articles
Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax
Available to PurchaseByoung-Kuk NA, Bhaskar R. SHENAI, Puran S. SIJWALI, Youngchool CHOE, Kailash C. PANDEY, Ajay SINGH, Charles S. CRAIK, Philip J. ROSENTHAL
Journal:
Biochemical Journal
Biochem J (2004) 378 (2): 529–538.
Published: 01 March 2004
...Byoung-Kuk NA; Bhaskar R. SHENAI; Puran S. SIJWALI; Youngchool CHOE; Kailash C. PANDEY; Ajay SINGH; Charles S. CRAIK; Philip J. ROSENTHAL Cysteine proteases play important roles in the life cycles of malaria parasites. Cysteine protease inhibitors block haemoglobin hydrolysis and development...
Articles
Characterization of non-covalent oligomers of proteins treated with hypochlorous acid
Available to PurchaseAnna L. P. CHAPMAN, Christine C. WINTERBOURN, Stephen O. BRENNAN, T. William JORDAN, Anthony J. KETTLE
Journal:
Biochemical Journal
Biochem J (2003) 375 (1): 33–40.
Published: 01 October 2003
... injury. The Biochemical Society, London ©2003 2003 haemoglobin myeloperoxidase myoglobin neutrophil protein aggregation protein oxidation Abbreviations used: DNP, 2,4-dinitrophenylhydrazine; ESI, electrospray ionization; HDL, high-density lipoprotein; LDL, low-density lipoprotein...
Articles
Structural-functional characterization of the cathodic haemoglobin of the conger eel Conger conger: molecular modelling study of an additional phosphate-binding site
Available to PurchaseMariagiuseppina PELLEGRINI, Bruno GIARDINA, Cinzia VERDE, Vito CARRATORE, Alessandra OLIANAS, Luigi SOLLAI, Maria T. SANNA, Massimo CASTAGNOLA, Guido di PRISCO
Journal:
Biochemical Journal
Biochem J (2003) 372 (3): 679–686.
Published: 15 June 2003
...Mariagiuseppina PELLEGRINI; Bruno GIARDINA; Cinzia VERDE; Vito CARRATORE; Alessandra OLIANAS; Luigi SOLLAI; Maria T. SANNA; Massimo CASTAGNOLA; Guido di PRISCO The Conger conger (conger eel) haemoglobin (Hb) system is made of three components, one of which, the so-called cathodic Hb, representing...
Articles
Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites
Available to PurchaseAjay SINGH, Bhaskar R. SHENAI, Youngchool CHOE, Jiri GUT, Puran S. SIJWALI, Charles S. CRAIK, Philip J. ROSENTHAL
Journal:
Biochemical Journal
Biochem J (2002) 368 (1): 273–281.
Published: 15 November 2002
... with P2 Leu and ready hydrolysis of haemoglobin. However, key differences between the plasmodial proteases were identified. In particular, vinckepain-2 showed very different kinetics against many substrates and an unusual preference for peptide substrates with P1 Gly. Replacement of Ala 23 with Gly...
Articles
Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes
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Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 801–808.
Published: 01 August 2002
... removing fructosamine residues from proteins. In the present study, we show that incubation of human erythrocytes with 200mM glucose not only caused the progressive formation of glycated haemoglobin, but also increased the level of an anionic form of haemoglobin containing alkali-labile phosphate...
Articles
Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 360 (2): 481–489.
Published: 26 November 2001
...Puran S. SIJWALI; Bhaskar R. SHENAI; Jiri GUT; Ajay SINGH; Philip J. ROSENTHAL In the malaria parasite Plasmodium falciparum , erythrocytic trophozoites hydrolyse haemoglobin to provide amino acids for parasite protein synthesis. Cysteine protease inhibitors block parasite haemoglobin hydrolysis...
Articles
Mechanism of malarial haem detoxification inhibition by chloroquine
Available to PurchaseAmit V. PANDEY, Himani BISHT, Vinod K. BABBARWAL, Jaya SRIVASTAVA, Kailash C. PANDEY, Virander S. CHAUHAN
Journal:
Biochemical Journal
Biochem J (2001) 355 (2): 333–338.
Published: 06 April 2001
...Amit V. PANDEY; Himani BISHT; Vinod K. BABBARWAL; Jaya SRIVASTAVA; Kailash C. PANDEY; Virander S. CHAUHAN The haem detoxification pathway of the malaria parasite Plasmodium falciparum is a potential biochemical target for drug development. Free haem, released after haemoglobin degradation...
Articles
Escherichia coli flavohaemoglobin (Hmp) with equistoichiometric FAD and haem contents has a low affinity for dioxygen in the absence or presence of nitric oxide
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Journal:
Biochemical Journal
Biochem J (2001) 353 (2): 207–213.
Published: 08 January 2001
... be compromised in hypoxic environments. Key words: bacterial NO detoxification, haemoglobin, NO oxygenase. anaerobically than aerobically [9] and hmp mutants are sensitive to NO and related species both aerobically and anaerobically [15], suggesting oxygen-independent modes of Hmp NO inter- actions. Secondly...
Articles
The role of amino acid α38 in the control of oxygen binding to human adult and embryonic haemoglobin Portland
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Journal:
Biochemical Journal
Biochem J (1999) 343 (3): 681–685.
Published: 25 October 1999
...Tao ZHENG; Thomas BRITTAIN; Nicholas J. WATMOUGH; Roy E. WEBER The role of the amino acid at position α 38 in haemoglobin has been probed using site-directed mutagenesis. When the Thr residue at position α 38 (which is totally conserved in all mammals) is changed to a Gln, the equilibrium...