...-bisphosphoglycerate phosphatase cancer glycolysis haemoglobin hypoxia mitochondrion oxygen sensing TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] is an important survival factor for cancer cells [ 1 ]. The enzymatic activity supported by sequence analysis led Bensaad et al...

... of nitrite salts for the treatment of cardiovascular conditions. 2 To whom correspondence should be addressed (email [email protected] ). 24 4 2012 15 6 2012 21 6 2012 21 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 haemoglobin inflammation...

...María T. Marcos-Almaraz; José A. Rodríguez-Gómez; José López-Barneo; Alberto Pascual Discovery of haemoglobin A expression outside of the erythroid cell lineage suggests that oxygen transport is the main, but not the unique, function of adult haemoglobin chains in mammals. The contribution...

...Brandon J. Reeder; Dimitri A. Svistunenko; Michael T. Wilson Cytoglobin is a recently discovered hexa-co-ordinate haemoglobin that does not appear to function as a classical oxygen-binding protein. Its function is unknown and studies on the effects of changes in its expression have not decisively...

...Louay Mardini; Jadwiga Gasiorek; Anna Derjuga; Lucie Carrière; Matthias Schranzhofer; Barry H. Paw; Prem Ponka; Volker Blank Late-stage erythroid cells synthesize large quantities of haemoglobin, a process requiring the co-ordinated regulation of globin and haem synthesis as well as iron uptake...

...Dominic P. Byrne; Katarzyna Wawrzonek; Anna Jaworska; Andrew J. Birss; Jan Potempa; John W. Smalley The Gram-negative oral anaerobe Prevotella intermedia forms an iron(III) protoporphyrin IX pigment from haemoglobin. The bacterium expresses a 90 kDa cysteine protease, InpA (interpain...

...Radu Silaghi-Dumitrescu; Brandon J. Reeder; Peter Nicholls; Chris E. Cooper; Michael T. Wilson Ferryl (Fe(IV)=O) species are involved in key enzymatic processes with direct biomedical relevance; among others, the uncontrolled reactivities of ferryl Mb (myoglobin) and Hb (haemoglobin) have been...

...Tao Hu; Belur N. Manjula; Dongxia Li; Michael Brenowitz; Seetharama A. Acharya The influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated {PEG [poly(ethylene glycol)]-conjugated} haemoglobin has been investigated. The sites and the extent...

...Jacqueline Dunne; Alexis Caron; Patrick Menu; Abdu I. Alayash; Paul W. Buehler; Michael T. Wilson; Radu Silaghi-Dumitrescu; Beatrice Faivre; Chris E. Cooper Haemoglobin initiates free radical chemistry. In particular, the interactions of peroxides with the ferric (met) species of haemoglobin...

... of the oxygen-transport haem protein from the Antarctic skate Bathyraja eatonii and from the Arctic skate Raja hyperborea (both of the subclass Elasmobranchii, order Rajiformes, family Rajidae) is reported in the present paper. These species have a single major haemoglobin (Hb 1; over 80% of the total...

... by a two-pronged effect of stalling the formation of haemozoin by the competitive inhibition of haem binding to its templates and creating a more reducing environment that is not conducive to the formation of haemozoin. artemisinin haemoglobin haemozoin Plasmodium falciparum histidine-rich protein...

...Yiping JIA; Somasundaram RAMASAMY; Francine WOOD; Abdu I. ALAYASH; Joseph M. RIFKIND O -R-polyHbA 0 is an intra- and intermolecularly O -raffinose cross-linked derivative of deoxygenated human haemoglobin developed as an oxygen therapeutic. When compared with its native protein (HbA 0 ), O -R...

...Kim D. VANDEGRIFF; Andrea BELLELLI; Michele SAMAJA; Ashok MALAVALLI; Maurizio BRUNORI; Robert M. WINSLOW The hypertensive effect observed with most cell-free haemoglobins has been proposed to result from NO scavenging. However, a newly developed PEG [poly(ethylene glycol)]-conjugated haemoglobin...

...M. Cristina DE ROSA; Massimo CASTAGNOLA; Claudia BERTONATI; Antonio GALTIERI; Bruno GIARDINA Haemoglobins from mammals of sub-Arctic and Arctic species, as well as fetal human Hb, are all characterized by a significantly lower Δ H of oxygenation compared with the majority of mammalian haemoglobins...

... a haemoglobin haemichrome. Inhibition of Arg-X protease activity of W50, W501, D7 and K1A with leupeptin, under conditions where Lys-X protease activity was unaffected, prevented the production of µ-oxo bishaem from oxyhaemoglobin, but resulted in the formation of a haemoglobin haemichrome. These results show...

...Byoung-Kuk NA; Bhaskar R. SHENAI; Puran S. SIJWALI; Youngchool CHOE; Kailash C. PANDEY; Ajay SINGH; Charles S. CRAIK; Philip J. ROSENTHAL Cysteine proteases play important roles in the life cycles of malaria parasites. Cysteine protease inhibitors block haemoglobin hydrolysis and development...

... injury. The Biochemical Society, London ©2003 2003 haemoglobin myeloperoxidase myoglobin neutrophil protein aggregation protein oxidation Abbreviations used: DNP, 2,4-dinitrophenylhydrazine; ESI, electrospray ionization; HDL, high-density lipoprotein; LDL, low-density lipoprotein...

...Mariagiuseppina PELLEGRINI; Bruno GIARDINA; Cinzia VERDE; Vito CARRATORE; Alessandra OLIANAS; Luigi SOLLAI; Maria T. SANNA; Massimo CASTAGNOLA; Guido di PRISCO The Conger conger (conger eel) haemoglobin (Hb) system is made of three components, one of which, the so-called cathodic Hb, representing...

... with P2 Leu and ready hydrolysis of haemoglobin. However, key differences between the plasmodial proteases were identified. In particular, vinckepain-2 showed very different kinetics against many substrates and an unusual preference for peptide substrates with P1 Gly. Replacement of Ala 23 with Gly...

... removing fructosamine residues from proteins. In the present study, we show that incubation of human erythrocytes with 200mM glucose not only caused the progressive formation of glycated haemoglobin, but also increased the level of an anionic form of haemoglobin containing alkali-labile phosphate...

...Puran S. SIJWALI; Bhaskar R. SHENAI; Jiri GUT; Ajay SINGH; Philip J. ROSENTHAL In the malaria parasite Plasmodium falciparum , erythrocytic trophozoites hydrolyse haemoglobin to provide amino acids for parasite protein synthesis. Cysteine protease inhibitors block parasite haemoglobin hydrolysis...

...Amit V. PANDEY; Himani BISHT; Vinod K. BABBARWAL; Jaya SRIVASTAVA; Kailash C. PANDEY; Virander S. CHAUHAN The haem detoxification pathway of the malaria parasite Plasmodium falciparum is a potential biochemical target for drug development. Free haem, released after haemoglobin degradation...

... be compromised in hypoxic environments. Key words: bacterial NO detoxification, haemoglobin, NO oxygenase. anaerobically than aerobically [9] and hmp mutants are sensitive to NO and related species both aerobically and anaerobically [15], suggesting oxygen-independent modes of Hmp NO inter- actions. Secondly...

...Tao ZHENG; Thomas BRITTAIN; Nicholas J. WATMOUGH; Roy E. WEBER The role of the amino acid at position α 38 in haemoglobin has been probed using site-directed mutagenesis. When the Thr residue at position α 38 (which is totally conserved in all mammals) is changed to a Gln, the equilibrium...