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Keywords: heart
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Biochem J (2019) 476 (12): 1713–1724.
Published: 19 June 2019
...Janet R. Manning; Dharendra Thapa; Manling Zhang; Michael W. Stoner; Javier Traba; Catherine Corey; Sruti Shiva; Michael N. Sack; Iain Scott GCN5L1 regulates protein acetylation and mitochondrial energy metabolism in diverse cell types. In the heart, loss of GCN5L1 sensitizes the myocardium...
Includes: Supplementary data
Biochem J (2016) 473 (15): 2413–2423.
Published: 28 July 2016
... and for diastolic heart failure with preserved ejection fraction. PLM (phospholemman), a substrate for protein kinases A and C, has been suggested to regulate NCX1 activity. However, although several studies have demonstrated that binding of phosphorylated PLM (pSer 68 -PLM) leads to NCX1 inhibition, other studies...
Biochem J (2016) 473 (9): 1165–1178.
Published: 26 April 2016
... sequence (RNA-Seq) databases demonstrates predominant expression of the Ca 2+ -sensitive archetype form in heart and skeletal muscle, but substantial expression of the Ca 2+ -insensitive variants in brain, pancreatic islets and other tissues. Detailed proteomic and activity studies comparing OGDH complexes...
Includes: Supplementary data
Biochem J (2015) 471 (1): 123–129.
Published: 21 September 2015
...Edgard M. Mejia; Jamal A. Ibdah; Genevieve C. Sparagna; Grant M. Hatch The contribution of α-subunit of trifunctional protein (αTFP) to cardiolipin (CL) (diphosphatidylglycerol) remodelling and mitochondrial supercomplex formation was examined in heart and liver mitochondria from wild-type (WT...
Biochem J (2013) 451 (1): 1–12.
Published: 14 March 2013
... fatty acid synthesis diacylglycerol acyltransferase heart hypertriglyceridaemia intestine lipogenesis liver muscle TAGs (triacylglycerols; also known as triglycerides) perform multiple functions in mammalian cells and in the traffic of substrates between tissues. They are a major source...
Biochem J (2012) 445 (3): 333–336.
Published: 13 July 2012
... ] and Perry et al. [ 1 ]. Under physiological conditions, an increase in the heart muscle contractile force is caused by increased ventricle filling, stretch of cardiomyocytes, increase in sarcomere length and decrease in the lattice spacing in myofibrils (length-dependent activation, the Frank–Starling law...
Includes: Multimedia, Supplementary data
Biochem J (2012) 443 (3): 829–839.
Published: 16 April 2012
.... In the fasted state, the PDH complex is inactivated by phosphorylation by PDHKs (pyruvate dehydrogenase kinases) to conserve three carbon compounds for the production of glucose [ 2 ]. © The Authors Journal compilation © 2012 Biochemical Society 2012 glucose heart hypothermia ketoacidosis liver...
Biochem J (2009) 424 (1): 99–107.
Published: 23 October 2009
... mitochondria translate to changes in bioenergetic events that take place in the myocardium during ischaemia/reperfusion and heart failure. Cardiac tissue is rich in mitochondria, which are capable of dynamically responding to energy demand for increased work. This oxidative phenotype allows for rapid...
Biochem J (2009) 424 (1): 119–127.
Published: 23 October 2009
... that contribute to the regulation of hUcn2 (human Ucn2) expression in cardiovascular pathologies are not known. In the present study, we analysed the mechanism by which hypoxia, a major stimulus in ischaemic heart disease, regulates Ucn2 gene expression. Hypoxia and CPX (ciclopirox olamine), which prevents...
Includes: Supplementary data
Biochem J (2009) 423 (3): 421–428.
Published: 12 October 2009
...Bernard Korzeniewski; Véronique Deschodt-Arsac; Guillaume Calmettes; Gilles Gouspillou; Jean-Michel Franconi; Philippe Diolez Mitochondrial respiration/oxidative phosphorylation is the main source of energy, in the form of ATP, in the heart under physiological conditions. Different respiratory...
Biochem J (2007) 406 (2): 309–315.
Published: 13 August 2007
... 2007 31 5 2007 31 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium channel excitation–contraction coupling heart maurocalcine ryanodine receptor toxin Ca 2+ signalling is a crucial step in the regulation of major cellular functions...
Biochem J (2006) 393 (1): 295–302.
Published: 12 December 2005
... in the heart. Transgene expression was maximal by 1 week of age and remained constant into adulthood. However, the changes in polyamine levels were most pronounced during the first week of age, with a 2-fold decrease in putrescine and spermidine and a 2-fold increase in spermine. At later times, spermine...
Includes: Supplementary data
Biochem J (2005) 385 (2): 469–477.
Published: 07 January 2005
... acyltransferase heart murine peroxisome-proliferator-activated receptor α (PPARα) Mammalian AGPAT (1-acyl- sn -glycerol 3-phosphate acyltransferase; EC, also known as lysophosphatidic acid acyltransferase, catalyses the acylation of lysophosphatidic acid to form PA (phosphatidic acid...
Biochem J (2003) 371 (1): 61–69.
Published: 01 April 2003
... and calsequestrin as 55 and 63kDa bands in 21 day fetal hearts. Only the 55kDa calsequestrin band was detected postnatally. Prenatal glucocorticoid overexposure at the higher dose decreased calreticulin protein expression (26%; P <0.05) but increased calsequestrin protein expression, both 55 and 63kDa bands...
Biochem J (2002) 368 (2): 545–553.
Published: 01 December 2002
... in these models of mitochondrial injury, a primary site of ROS generation in both brain and heart mitochondria is proximal to the rotenone inhibitory site, rather than in complex III. ROS production at complex I is critically dependent upon a highly reduced state of the mitochondrial NAD(P) + pool and is achieved...
Biochem J (2002) 368 (1): 101–110.
Published: 15 November 2002
..., Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K. (e-mail a.clerk@ic.ac.uk ). 10 7 2002 5 8 2002 8 8 2002 8 8 2002 The Biochemical Society, London ©2002 2002 heart immediate...
Biochem J (2002) 361 (1): 49–56.
Published: 17 December 2001
... was present in brown-adipose-tissue mitochondria from warm-adapted rats but was undetectable in rat heart mitochondria. We expressed human UCP3 in yeast mitochondria at levels similar to, double and 7-fold those found in rodent skeletal-muscle mitochondria. Yeast mitochondria containing UCP3 were more...
Biochem J (2001) 359 (2): 375–380.
Published: 08 October 2001
...- apoptotic signalling in the heart. Therefore it is important to understand the mechanism of ET-1 signal transduction in cardiac myocytes. GATA-4 is a member of the GATA family of zinc-finger transcription factors which play important roles in cell growth, differentiation and survival. Six GATA family...
Biochem J (2001) 359 (1): 47–54.
Published: 24 September 2001
... elements. Key words: cytoskeleton, GLUT4 translocation, heart, 12- lipoxygenase, 12(S)-hydroxyeicosatetraenoic acid. the phosphorylation of actin fibres, leading to an increased actin filament content and enhancement of actin polymerization [9 11]. LOs are known to form a widely distributed family of lipid...
Biochem J (1999) 341 (2): 347–354.
Published: 08 July 1999
...Adrienne N. BOONE; Brian RODRIGUES; Roger W. BROWNSEY Two major forms of mammalian acetyl-CoA carboxylase (EC, ACC-α and ACC-β, have been described and the sequences of the isoforms deduced. ACC-β is the predominant isoform expressed in heart and skeletal muscles, in which a major role...
Biochem J (1999) 340 (2): 485–490.
Published: 25 May 1999
...H. Stephen EWART; David L. SEVERSON Lipoprotein lipase (LPL) activity in cultured ventricular cardiomyocytes from adult rat hearts was stimulated by the combination of insulin (100 nM) and dexamethasone (100 nM) during an overnight (16 h) incubation. Wortmannin (100 nM), rapamycin (30 ng/ml...