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1-21 of 21
Keywords: heart
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Articles
Janet R. Manning, Dharendra Thapa, Manling Zhang, Michael W. Stoner, Javier Traba, Catherine Corey, Sruti Shiva, Michael N. Sack, Iain Scott
Journal:
Biochemical Journal
Biochem J (2019) 476 (12): 1713–1724.
Published: 19 June 2019
...Janet R. Manning; Dharendra Thapa; Manling Zhang; Michael W. Stoner; Javier Traba; Catherine Corey; Sruti Shiva; Michael N. Sack; Iain Scott GCN5L1 regulates protein acetylation and mitochondrial energy metabolism in diverse cell types. In the heart, loss of GCN5L1 sensitizes the myocardium...
Includes: Supplementary data
Articles
Pimthanya Wanichawan, Kjetil Hodne, Tandekile Lubelwana Hafver, Marianne Lunde, Marita Martinsen, William Edward Louch, Ole Mathias Sejersted, Cathrine Rein Carlson
Journal:
Biochemical Journal
Biochem J (2016) 473 (15): 2413–2423.
Published: 28 July 2016
... and for diastolic heart failure with preserved ejection fraction. PLM (phospholemman), a substrate for protein kinases A and C, has been suggested to regulate NCX1 activity. However, although several studies have demonstrated that binding of phosphorylated PLM (pSer 68 -PLM) leads to NCX1 inhibition, other studies...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (9): 1165–1178.
Published: 26 April 2016
... sequence (RNA-Seq) databases demonstrates predominant expression of the Ca 2+ -sensitive archetype form in heart and skeletal muscle, but substantial expression of the Ca 2+ -insensitive variants in brain, pancreatic islets and other tissues. Detailed proteomic and activity studies comparing OGDH complexes...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 471 (1): 123–129.
Published: 21 September 2015
...Edgard M. Mejia; Jamal A. Ibdah; Genevieve C. Sparagna; Grant M. Hatch The contribution of α-subunit of trifunctional protein (αTFP) to cardiolipin (CL) (diphosphatidylglycerol) remodelling and mitochondrial supercomplex formation was examined in heart and liver mitochondria from wild-type (WT...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 451 (1): 1–12.
Published: 14 March 2013
... fatty acid synthesis diacylglycerol acyltransferase heart hypertriglyceridaemia intestine lipogenesis liver muscle Early observations showed that, indeed, DAG esterifying activity (DGAT activity) is expressed on both aspects of the membrane, i.e. that there are ‘overt’ and ‘latent’ DGAT...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 445 (3): 333–336.
Published: 13 July 2012
... ] and Perry et al. [ 1 ]. Under physiological conditions, an increase in the heart muscle contractile force is caused by increased ventricle filling, stretch of cardiomyocytes, increase in sarcomere length and decrease in the lattice spacing in myofibrils (length-dependent activation, the Frank–Starling law...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 443 (3): 829–839.
Published: 16 April 2012
... 2012 glucose heart hypothermia ketoacidosis liver pyruvate dehydrogenase complex (PDH complex) pyruvate dehydrogenase kinase (PDHK) skeletal muscle The PDH complex (pyruvate dehydrogenase complex) plays a pivotal role in controlling the concentrations of glucose in the fed...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 424 (1): 99–107.
Published: 23 October 2009
... of understanding how changes in isolated mitochondria translate to changes in bioenergetic events that take place in the myocardium during ischaemia/reperfusion and heart failure. Cardiac tissue is rich in mitochondria, which are capable of dynamically responding to energy demand for increased work. This oxidative...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 424 (1): 119–127.
Published: 23 October 2009
... that contribute to the regulation of hUcn2 (human Ucn2) expression in cardiovascular pathologies are not known. In the present study, we analysed the mechanism by which hypoxia, a major stimulus in ischaemic heart disease, regulates Ucn2 gene expression. Hypoxia and CPX (ciclopirox olamine), which prevents...
Includes: Supplementary data
Articles
Bernard Korzeniewski, Véronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Jean-Michel Franconi, Philippe Diolez
Journal:
Biochemical Journal
Biochem J (2009) 423 (3): 421–428.
Published: 12 October 2009
...Bernard Korzeniewski; Véronique Deschodt-Arsac; Guillaume Calmettes; Gilles Gouspillou; Jean-Michel Franconi; Philippe Diolez Mitochondrial respiration/oxidative phosphorylation is the main source of energy, in the form of ATP, in the heart under physiological conditions. Different respiratory...
Articles
Xavier Altafaj, Julien France, Janos Almassy, Istvan Jona, Daniela Rossi, Vincenzo Sorrentino, Kamel Mabrouk, Michel De Waard, Michel Ronjat
Journal:
Biochemical Journal
Biochem J (2007) 406 (2): 309–315.
Published: 13 August 2007
..., no spontaneous Ca 2+ release was observed. calcium channel excitation–contraction coupling heart maurocalcine ryanodine receptor toxin Ca 2+ signalling is a crucial step in the regulation of major cellular functions. Oscillations of cytosolic Ca 2+ concentration result from the balance...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 295–302.
Published: 12 December 2005
... in the heart. Transgene expression was maximal by 1 week of age and remained constant into adulthood. However, the changes in polyamine levels were most pronounced during the first week of age, with a 2-fold decrease in putrescine and spermidine and a 2-fold increase in spermine. At later times, spermine...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 385 (2): 469–477.
Published: 07 January 2005
... acyltransferase heart murine peroxisome-proliferator-activated receptor α (PPARα) Mammalian AGPAT (1-acyl- sn -glycerol 3-phosphate acyltransferase; EC 2.3.1.51), also known as lysophosphatidic acid acyltransferase, catalyses the acylation of lysophosphatidic acid to form PA (phosphatidic acid...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 371 (1): 61–69.
Published: 01 April 2003
... and calsequestrin as 55 and 63kDa bands in 21 day fetal hearts. Only the 55kDa calsequestrin band was detected postnatally. Prenatal glucocorticoid overexposure at the higher dose decreased calreticulin protein expression (26%; P <0.05) but increased calsequestrin protein expression, both 55 and 63kDa bands...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 368 (2): 545–553.
Published: 01 December 2002
... in these models of mitochondrial injury, a primary site of ROS generation in both brain and heart mitochondria is proximal to the rotenone inhibitory site, rather than in complex III. ROS production at complex I is critically dependent upon a highly reduced state of the mitochondrial NAD(P) + pool and is achieved...
Articles
Angela CLERK, Timothy J. KEMP, Joanne G. HARRISON, Anthony J. MULLEN, Paul J.R. BARTON, Peter H. SUGDEN
Journal:
Biochemical Journal
Biochem J (2002) 368 (1): 101–110.
Published: 15 November 2002
..., Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K. (e-mail [email protected] ). 10 7 2002 5 8 2002 8 8 2002 8 8 2002 The Biochemical Society, London ©2002 2002 heart immediate...
Articles
James A. HARPER, Jeff A. STUART, Mika B. JEKABSONS, Damien ROUSSEL, Kevin M. BRINDLE, Keith DICKINSON, Robert B. JONES, Martin D. BRAND
Journal:
Biochemical Journal
Biochem J (2002) 361 (1): 49–56.
Published: 17 December 2001
... was present in brown-adipose-tissue mitochondria from warm-adapted rats but was undetectable in rat heart mitochondria. We expressed human UCP3 in yeast mitochondria at levels similar to, double and 7-fold those found in rodent skeletal-muscle mitochondria. Yeast mitochondria containing UCP3 were more...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 359 (2): 375–380.
Published: 08 October 2001
.... Thus ET-1 induces a GATA-4 phosphorylation by activating a MEK–MAPK pathway. cardiac muscle heart mitogen-activated protein kinase Abbreviations used: ANF, atrial natriuretic factor; BNP, brain natriuretic peptide; EMSA, electrophoretic-mobility-shift assay; ET-1, endothelin-1; λPPase, λ...
Articles
Olaf DRANSFELD, Irini RAKATZI, Shlomo SASSON, Arie GRUZMAN, Marcus SCHMITT, Dieter HÄUSSINGER, Jürgen ECKEL
Journal:
Biochemical Journal
Biochem J (2001) 359 (1): 47–54.
Published: 24 September 2001
... of actin cytoskeletal elements. 1 To whom correspondence should be addressed (e-mail [email protected] ). 27 4 2001 18 6 2001 24 7 2001 The Biochemical Society, London ©2001 2001 cytoskeleton GLUT4 translocation heart 12-lipoxygenase 12(S...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 341 (2): 347–354.
Published: 08 July 1999
...Adrienne N. BOONE; Brian RODRIGUES; Roger W. BROWNSEY Two major forms of mammalian acetyl-CoA carboxylase (EC 6.4.1.2), ACC-α and ACC-β, have been described and the sequences of the isoforms deduced. ACC-β is the predominant isoform expressed in heart and skeletal muscles, in which a major role...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 340 (2): 485–490.
Published: 25 May 1999
...H. Stephen EWART; David L. SEVERSON Lipoprotein lipase (LPL) activity in cultured ventricular cardiomyocytes from adult rat hearts was stimulated by the combination of insulin (100 nM) and dexamethasone (100 nM) during an overnight (16 h) incubation. Wortmannin (100 nM), rapamycin (30 ng/ml...