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Keywords: heart
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Articles
Biochem J (2019) 476 (12): 1713–1724.
Published: 19 June 2019
...Janet R. Manning; Dharendra Thapa; Manling Zhang; Michael W. Stoner; Javier Traba; Catherine Corey; Sruti Shiva; Michael N. Sack; Iain Scott GCN5L1 regulates protein acetylation and mitochondrial energy metabolism in diverse cell types. In the heart, loss of GCN5L1 sensitizes the myocardium...
Includes: Supplementary data
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Biochem J (2016) 473 (9): 1165–1178.
Published: 26 April 2016
... sequence (RNA-Seq) databases demonstrates predominant expression of the Ca 2+ -sensitive archetype form in heart and skeletal muscle, but substantial expression of the Ca 2+ -insensitive variants in brain, pancreatic islets and other tissues. Detailed proteomic and activity studies comparing OGDH complexes...
Includes: Supplementary data
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Biochem J (2013) 451 (1): 1–12.
Published: 14 March 2013
... fatty acid synthesis diacylglycerol acyltransferase heart hypertriglyceridaemia intestine lipogenesis liver muscle Early observations showed that, indeed, DAG esterifying activity (DGAT activity) is expressed on both aspects of the membrane, i.e. that there are ‘overt’ and ‘latent’ DGAT...
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Biochem J (2012) 445 (3): 333–336.
Published: 13 July 2012
... ] and Perry et al. [ 1 ]. Under physiological conditions, an increase in the heart muscle contractile force is caused by increased ventricle filling, stretch of cardiomyocytes, increase in sarcomere length and decrease in the lattice spacing in myofibrils (length-dependent activation, the Frank–Starling law...
Includes: Multimedia, Supplementary data
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Biochem J (2012) 443 (3): 829–839.
Published: 16 April 2012
... 2012 glucose heart hypothermia ketoacidosis liver pyruvate dehydrogenase complex (PDH complex) pyruvate dehydrogenase kinase (PDHK) skeletal muscle The PDH complex (pyruvate dehydrogenase complex) plays a pivotal role in controlling the concentrations of glucose in the fed...
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Biochem J (2009) 424 (1): 99–107.
Published: 23 October 2009
... of understanding how changes in isolated mitochondria translate to changes in bioenergetic events that take place in the myocardium during ischaemia/reperfusion and heart failure. Cardiac tissue is rich in mitochondria, which are capable of dynamically responding to energy demand for increased work. This oxidative...
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Biochem J (2009) 424 (1): 119–127.
Published: 23 October 2009
... that contribute to the regulation of hUcn2 (human Ucn2) expression in cardiovascular pathologies are not known. In the present study, we analysed the mechanism by which hypoxia, a major stimulus in ischaemic heart disease, regulates Ucn2 gene expression. Hypoxia and CPX (ciclopirox olamine), which prevents...
Includes: Supplementary data
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Biochem J (2007) 406 (2): 309–315.
Published: 13 August 2007
..., no spontaneous Ca 2+ release was observed. calcium channel excitation–contraction coupling heart maurocalcine ryanodine receptor toxin Ca 2+ signalling is a crucial step in the regulation of major cellular functions. Oscillations of cytosolic Ca 2+ concentration result from the balance...
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Biochem J (2006) 393 (1): 295–302.
Published: 12 December 2005
... in the heart. Transgene expression was maximal by 1 week of age and remained constant into adulthood. However, the changes in polyamine levels were most pronounced during the first week of age, with a 2-fold decrease in putrescine and spermidine and a 2-fold increase in spermine. At later times, spermine...
Includes: Supplementary data
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Biochem J (2002) 368 (2): 545–553.
Published: 01 December 2002
... in these models of mitochondrial injury, a primary site of ROS generation in both brain and heart mitochondria is proximal to the rotenone inhibitory site, rather than in complex III. ROS production at complex I is critically dependent upon a highly reduced state of the mitochondrial NAD(P) + pool and is achieved...
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Biochem J (2001) 359 (2): 375–380.
Published: 08 October 2001
.... Thus ET-1 induces a GATA-4 phosphorylation by activating a MEK–MAPK pathway. cardiac muscle heart mitogen-activated protein kinase Abbreviations used: ANF, atrial natriuretic factor; BNP, brain natriuretic peptide; EMSA, electrophoretic-mobility-shift assay; ET-1, endothelin-1; λPPase, λ...
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Biochem J (1999) 340 (2): 485–490.
Published: 25 May 1999
...H. Stephen EWART; David L. SEVERSON Lipoprotein lipase (LPL) activity in cultured ventricular cardiomyocytes from adult rat hearts was stimulated by the combination of insulin (100 nM) and dexamethasone (100 nM) during an overnight (16 h) incubation. Wortmannin (100 nM), rapamycin (30 ng/ml...