...Ryan J. Buckley; Kevin Kramm; Christopher D. O. Cooper; Dina Grohmann; Edward L. Bolt The DNA helicase L arge h elicase -r elated (Lhr) is present throughout archaea, including in the Asgard and Nanoarchaea, and has homologues in bacteria and eukaryotes. It is thought to function in DNA repair...

... replication progression which can lead to the generation of DNA double-strand breaks and genome instability. Helicases have been shown to resolve G4 structures to facilitate faithful duplication of the genome. Escherichia coli UvrD (EcUvrD) helicase plays a crucial role in nucleotide excision repair, mismatch...

...Furqan Sami; Xing Lu; Swetha Parvathaneni; Rabindra Roy; Ronald K. Gary; Sudha Sharma RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in replication restart mechanisms. Cellular phenotypes of RECQ1 deficiency are indicative...

...Anne-Marie McRobbie; Bjoern Meyer; Christophe Rouillon; Biljana Petrovic-Stojanovska; Huanting Liu; Malcolm F. White DinG (damage inducible gene G) is a bacterial superfamily 2 helicase with 5′→3′ polarity. DinG is related to the XPD (xeroderma pigmentosum complementation group D) helicase family...

...Lisa Dohrn; Daniela Salles; Simone Y. Siehler; Julia Kaufmann; Lisa Wiesmüller BACH1 (BRCA1-associated C-terminal helicase 1), the product of the BRIP1 {BRCA1 [breast cancer 1, early onset]-interacting protein C-terminal helicase 1; also known as FANCJ [FA-J (Fanconi anaemia group J) protein]} gene...

...-loops, hybrids of RNA base-paired into duplex DNA. ATP abolishes Cas3 R-loop formation and instead powers Cas3 helicase unwinding of the invading RNA strand of a model R-loop substrate. R-loop formation by Cas3 requires magnesium as a co-factor and is inactivated by mutagenesis of a conserved amino acid...

...Li Phing Liew; Stephen D. Bell The MCM (minichromosome maintenance) proteins of archaea are widely believed to be the replicative DNA helicase of these organisms. Most archaea possess a single MCM orthologue that forms homo-multimeric assemblies with a single hexamer believed to be the active form...

...Sudha Sharma; Kevin M. Doherty; Robert M. Brosh, Jr Helicases are molecular motor proteins that couple the hydrolysis of NTP to nucleic acid unwinding. The growing number of DNA helicases implicated in human disease suggests that their vital specialized roles in cellular pathways are important...

...Rajesh K. Soni; Parul Mehra; Gauranga Mukhopadhyay; Suman Kumar Dhar In Escherichia coli , DnaC is essential for loading DnaB helicase at ori C (the origin of chromosomal DNA replication). The question arises as to whether this model can be generalized to other species, since many eubacterial...