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1-22 of 22
Keywords: heparan sulphate
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Articles
Nicholas J. Harmer, Christopher J. Robinson, Lucy E. Adam, Leopold L. Ilag, Carol V. Robinson, John T. Gallagher, Tom L. Blundell
Journal:
Biochemical Journal
Biochem J (2006) 393 (3): 741–748.
Published: 13 January 2006
... by size-exclusion chromatography as described previously [ 38 ]. The Biochemical Society, London 2006 fibroblast growth factor (FGF) focal complex heparin heparan sulphate receptor clustering Members of the FGF (fibroblast growth factor) family of proteins are found in all animals...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 391 (1): 125–134.
Published: 26 September 2005
...) and GlcNH 2 [(N-unsubstituted) glucosamine] residues of heparan sulphate are potential targets for HOCl. It is shown here that HOCl reacts with each of these residues to generate N-chloro derivatives, and the absolute rate constants for these reactions have been determined. Reaction at GlcNH 2 residues...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 390 (2): 493–499.
Published: 23 August 2005
...Giancarlo Ghiselli; Amit Agrawal Heparan sulphate (HS) is a ubiquitous constituent of the extracellular matrix that is required for the biological activity of circulating soluble and insoluble extracellular ligands. GLCE ( D -glucuronyl C5-epimerase), an enzyme responsible for the epimerization...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 383–388.
Published: 05 July 2005
... ). 1 11 2004 1 2 2005 3 3 2005 3 3 2005 The Biochemical Society, London 2005 chemical modification heparan sulphate MS modification degree stable isotope sulphotransferase Because the natural abundance of each stable isotope is relatively constant...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 385 (2): 451–459.
Published: 07 January 2005
...Ding XU; Vaibhav TIWARI; Guoqing XIA; Christian CLEMENT; Deepak SHUKLA; Jian LIU Heparan sulphate (HS) 3-O-sulphotransferase transfers sulphate to the 3-OH position of the glucosamine residue of HS to form 3-O-sulphated HS. The HS modified by 3-O-sulphotransferase isoform 3 binds to HSV-1 (herpes...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 384 (3): 495–505.
Published: 07 December 2004
... (heparan sulphate)-binding sequences. To investigate the functional role of these domains, we have generated both wild-type and mutant recombinant anosmin-1 proteins using a Drosophila S2 cell expression system. Here we present the first biochemical evidence demonstrating the high-binding affinity between...
Articles
Christophe VANPOUILLE, Agnès DENYS, Mathieu CARPENTIER, Rachel PAKULA, Joël MAZURIER, Fabrice ALLAIN
Journal:
Biochemical Journal
Biochem J (2004) 382 (2): 733–740.
Published: 24 August 2004
...-lymphocytes by way of interaction with two types of binding sites. The first site corresponds to a signalling receptor; the second site has been identified as heparan sulphate (HS) and appears crucial to induce cell adhesion. Characterization of the HS-binding unit is critical to understand the requirement...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 381 (3): 593–597.
Published: 27 July 2004
...Anna M. VOGT; Gerhard WINTER; Mats WAHLGREN; Dorothe SPILLMANN HS (heparan sulphate) has hitherto not been found on human red blood cells (RBCs, erythrocytes). However, malarial-parasite ( Plasmodium falciparum )-infected RBCs adhere to uninfected RBCs via HS-like receptors. In the present paper we...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 379 (2): 331–341.
Published: 15 April 2004
...Chia Lin CHU; J. Ann BUCZEK-THOMAS; Matthew A. NUGENT We investigated how lipid raft association of HSPG (heparan sulphate proteoglycans) modulates FGF-2 (fibroblast growth factor-2/basic fibroblast growth factor) interactions with vascular smooth-muscle cells. When lipid rafts were disrupted...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 533–538.
Published: 15 January 2004
...-regulated by this inflammatory stimulus. By immunoprecipitation using an anti-syndecan-2 antibody on TNF-α-stimulated HUVEC lysates, inflammation-induced interleukin-8 was found to be an interaction partner of this HS (heparan sulphate) proteoglycan, but not of any other syndecan on these cells...
Articles
Edward McKENZIE, Kathryn YOUNG, Margaret HIRCOCK, James BENNETT, Maina BHAMAN, Robert FELIX, Paul TURNER, Alasdair STAMPS, David McMILLAN, Giles SAVILLE, Stanley NG, Sean MASON, Daniel SNELL, Darren SCHOFIELD, Haiping GONG, Reid TOWNSEND, John GALLAGHER, Martin PAGE, Raj PAREKH, Colin STUBBERFIELD
Journal:
Biochemical Journal
Biochem J (2003) 373 (2): 423–435.
Published: 15 July 2003
... The mammalian endoglycosidase heparanase (Hpa1) is primarily responsible for cleaving heparan sulphate proteoglycans (HSPGs) present on the basement membrane of cells and its potential for remodelling the extracellular matrix (ECM) could be important in embryonic development and tumour metastasis. Elevated...
Articles
Emanuel SMEDS, Hiroko HABUCHI, Anh-Tri DO, Eva HJERTSON, Helena GRUNDBERG, Koji KIMATA, Ulf LINDAHL, Marion KUSCHE-GULLBERG
Journal:
Biochemical Journal
Biochem J (2003) 372 (2): 371–380.
Published: 01 June 2003
...Emanuel SMEDS; Hiroko HABUCHI; Anh-Tri DO; Eva HJERTSON; Helena GRUNDBERG; Koji KIMATA; Ulf LINDAHL; Marion KUSCHE-GULLBERG Glycosaminoglycan heparan sulphate interacts with a variety of proteins, such as growth factors, cytokines, enzymes and inhibitors and, thus, influences cellular functions...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 366 (2): 481–490.
Published: 01 September 2002
... transcription and translation yielded a product of 30kDa. Western blotting of chicken embryonic fibroblast cell lysates with species-specific monoclonal antibody mAb 8.1 showed that chicken syndecan-2 is substituted with heparan sulphate, and that the major form of chicken syndecan-2 isolated from chicken...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 366 (1): 235–244.
Published: 15 August 2002
... parameters and the potency of the oligosaccharides in DNA synthesis assays. These results demonstrate that tetrasaccharides are able to bind FGF-2 and enable FGF-2 to stimulate cell proliferation, which sets important boundary conditions for models of the FGF-2—heparan sulphate—FGF receptor complex. 1...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 358 (3): 737–745.
Published: 10 September 2001
...Simi ALI; Adrian C. V. PALMER; Sarah J. FRITCHLEY; Yvonne MALEY; John A. KIRBY Chemokines interact with specific G-protein-coupled cell-surface receptors and with glycosaminoglycans (GAGs), such as heparan sulphate. Although chemokines often form multimers in solution, this process may be enhanced...
Articles
Alexis ROBERTSON, Gavin S. MacCOLL, Julia A.B. NASH, Mark K. BOEHM, Stephen J. PERKINS, Pierre-Marc G. BOULOUX
Journal:
Biochemical Journal
Biochem J (2001) 357 (3): 647–659.
Published: 25 July 2001
... mutation-encoded amino acid substitutions, N267K, E514K and F517L, were mapped to structurally defined positions on the GFCC′ β-sheet face of the first and third FnIII domains. Electrostatic maps demonstrated large basic surfaces containing clusters of conserved predicted heparan sulphate-binding residues...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 355 (2): 517–527.
Published: 06 April 2001
... transformed counterpart (RT101). Expression of perlecan in tumorigenic cells was significantly increased in both mRNA and protein levels. JB6 perlecan was exclusively substituted with heparan sulphate, whereas that of RT101 contained some additional chondroitin sulphate. Detailed structural analysis...
Articles
Oligomerization reduces heparin affinity but enhances receptor binding of fibroblast growth factor 2
Journal:
Biochemical Journal
Biochem J (2000) 345 (1): 107–113.
Published: 17 December 1999
...Michal SAFRAN; Miriam EISENSTEIN; David AVIEZER; Avner YAYON The biological response of cells to fibroblast growth factors (FGFs) depends on heparan sulphate glycosaminoglycans sharing particular structural motifs. Heparin induced FGF dimerization has been suggested to mediate receptor dimerization...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 343 (3): 663–668.
Published: 25 October 1999
...Karen P. SCHOFIELD; John T. GALLAGHER; Guido DAVID Heparan sulphate proteoglycans (HSPGs) present on the surface of bone marrow stromal cells and in the extracellular matrix (ECM) have important roles in the control of adhesion and growth of haemopoietic stem and progenitor cells. The two main...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 342 (2): 361–368.
Published: 24 August 1999
... heparanase, which cleaves heparan sulphate (HS), an important structural component of the vascular BL. Previously, tumour-derived heparanase activity (which has been shown to be related to the metastatic potential of murine and human melanoma cell lines) was reported to cleave HS and be inhibited by heparin...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 340 (3): 613–620.
Published: 08 June 1999
... a molecular mass of 1.1×10 6 Da, and EM demonstrated that it had a globular-protein core structure. The core protein, which showed immunological reactivity with perlecan antibodies, was substituted with approximately seven heparan sulphate (HS) and CS chains of similar size (50-55 kDa), the CS disaccharides...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 338 (2): 317–323.
Published: 22 February 1999
...Mattias BELTING; Susanne PERSSON; Lars-Åke FRANSSON We have evaluated the possible role of proteoglycans in the uptake of spermine by human lung fibroblasts. Exogenous glycosaminoglycans behaved as competitive inhibitors of spermine uptake, the most efficient being heparan sulphate ( K i = 0.16...